Open Access

Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk

  • Authors:
    • Xiao‑Hui Liang
    • Dong Yan
    • Jia‑Xing Zhao
    • Wei Ding
    • Xin‑Jian Xu
    • Xi‑Yan Wang
  • View Affiliations

  • Published online on: August 23, 2018     https://doi.org/10.3892/ol.2018.9350
  • Pages: 5631-5638
  • Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the association between xeroderma pigmentosum group C (XPC) polymorphisms and pancreatic cancer (PC) risk. A total of 7 XPC tagging SNPs (tag‑SNPs) were selected from the International HapMap Project Databases (rs2228001A/C, rs2470353G/C, rs2228000C/T, rs3731114C/G, rs3729587G/C, rs2607775C/G and rs3731055G/A) and were genotyped in 205 patients with PC and 230 non‑cancer control subjects using a SNaPshot assay. The C allelic gene frequency of rs2470353 was higher in patients with PC compared with that in the control group (P=0.003). Compared with the GG gene type, PC risk was increased in subjects with GC and GC+CC gene types (P=0.012 and P=0.006, respectively). PC risk increased 3.505‑fold for the subjects who were heavy smokers (tobacco, ≥25 packets/year) with the GC+CC gene type (P=0.008). The G allelic gene frequency of rs2607775 was higher in PC patients compared with that in the control group (P=0.003). Compared with the CC gene type, PC risk increased in subjects with CG and CG+GG gene types (P=0.013 and P=0.005, respectively). Furthermore, PC risk increased 3.950‑fold in subjects who were heavy smokers (tobacco, ≥25 packets/year) with the CG+GG gene type (P=0.001). Haplotype analysis further revealed that the CCC haplotype of rs2228000, rs3731114 and rs3729587 increased PC risk (odds ratio, 1.610; 95% confidence interval, 1.035‑2.481; P=0.034). The present study revealed that XPC gene polymorphisms could increase the risk of PC in the study population, particularly among heavy smokers.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liang XH, Yan D, Zhao JX, Ding W, Xu XJ and Wang XY: Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk. Oncol Lett 16: 5631-5638, 2018.
APA
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., & Wang, X. (2018). Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk. Oncology Letters, 16, 5631-5638. https://doi.org/10.3892/ol.2018.9350
MLA
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., Wang, X."Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk". Oncology Letters 16.5 (2018): 5631-5638.
Chicago
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., Wang, X."Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk". Oncology Letters 16, no. 5 (2018): 5631-5638. https://doi.org/10.3892/ol.2018.9350