The novel three‑way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3‑ITD mutation: A case report

  • Authors:
    • Yong‑Lu Zhang
    • Mei Jiang
    • Shu‑Qing Luan
    • Shu‑Yuan Liu
    • Jin‑Hua Wan
    • La‑Gen Wan
    • Zhang‑Lin Zhang
  • View Affiliations

  • Published online on: September 6, 2018     https://doi.org/10.3892/ol.2018.9413
  • Pages: 6121-6125
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Abstract

Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17)(q22;q21), resulting in the fusion of the promyelocytic leukemia gene at 15q22 with the retinoic acid receptor α at 17q21. Additionally, all patients with APL who have additional chromosome abnormalities (ACA) and gene mutations are resistant to all‑trans retinoic acid (ATRA), the drug that causes disease regression specifically in patients with APL globally. The present study describes a case of a 19‑year‑old female with APL carrying a novel complex variant translocation t(6;17;15)(p21;q21;q22), add(7)(q32) and an FMS‑related tyrosine kinase 3 internal tandem duplication (FLT3‑ITD) mutation. Complete remission was attained following a course of chemotherapy with ATRA and arsenic trioxide. To the best of our knowledge, this is the first report of a novel three‑way translocation of 6p21 and a FLT3‑ITD mutation involved with APL.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang YL, Jiang M, Luan SQ, Liu SY, Wan JH, Wan LG and Zhang ZL: The novel three‑way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3‑ITD mutation: A case report. Oncol Lett 16: 6121-6125, 2018.
APA
Zhang, Y., Jiang, M., Luan, S., Liu, S., Wan, J., Wan, L., & Zhang, Z. (2018). The novel three‑way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3‑ITD mutation: A case report. Oncology Letters, 16, 6121-6125. https://doi.org/10.3892/ol.2018.9413
MLA
Zhang, Y., Jiang, M., Luan, S., Liu, S., Wan, J., Wan, L., Zhang, Z."The novel three‑way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3‑ITD mutation: A case report". Oncology Letters 16.5 (2018): 6121-6125.
Chicago
Zhang, Y., Jiang, M., Luan, S., Liu, S., Wan, J., Wan, L., Zhang, Z."The novel three‑way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3‑ITD mutation: A case report". Oncology Letters 16, no. 5 (2018): 6121-6125. https://doi.org/10.3892/ol.2018.9413