Open Access

Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review

  • Authors:
    • Xiaorui Fu
    • Yufeng Shang
    • Lei Zhang
    • Ling Li
    • Xin Li
    • Xinhua Wang
    • Zhenchang Sun
    • Mingzhi Zhang
  • View Affiliations

  • Published online on: September 18, 2018     https://doi.org/10.3892/ol.2018.9447
  • Pages: 6624-6632
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study reports two cases of concurrently diagnosed T‑lymphoblastic lymphoma (T‑LBL) and chronic myeloid leukemia (CML). The literature review revealed that myeloid leukemia may appear secondary to Hodgkin lymphoma or non‑Hodgkin lymphoma. However, simultaneous bi‑lineage hematologic malignancies are rarely seen and the prognosis is worse than single lineage lymphoma or myeloid leukemia. There were no standard therapies. All simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma reported in Pubmed were combined with the present two cases, to analyses its pathogenesis, features and treatment. It was concluded that the prognosis of bi‑lineage hematologic malignancies was poor, however allogeneic hematopoietic stem cell transplantation could improve survival (P=0.033).
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Fu X, Shang Y, Zhang L, Li L, Li X, Wang X, Sun Z and Zhang M: Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review. Oncol Lett 16: 6624-6632, 2018.
APA
Fu, X., Shang, Y., Zhang, L., Li, L., Li, X., Wang, X. ... Zhang, M. (2018). Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review. Oncology Letters, 16, 6624-6632. https://doi.org/10.3892/ol.2018.9447
MLA
Fu, X., Shang, Y., Zhang, L., Li, L., Li, X., Wang, X., Sun, Z., Zhang, M."Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review". Oncology Letters 16.5 (2018): 6624-6632.
Chicago
Fu, X., Shang, Y., Zhang, L., Li, L., Li, X., Wang, X., Sun, Z., Zhang, M."Analyses and treatment of simultaneous bi‑lineage malignancies of myeloid leukemia and lymphoma: Two case reports and a literature review". Oncology Letters 16, no. 5 (2018): 6624-6632. https://doi.org/10.3892/ol.2018.9447