Association analyses of the JAK/STAT signaling pathway with the progression and prognosis of colon cancer

Tang,Shengbo; Yuan,Xihong; Song,Jintian; Chen,Yigui; Tan,Xiaojie; Li,Qiyun

doi:10.3892/ol.2018.9569

Association analyses of the JAK/STAT signaling pathway with the progression and prognosis of colon cancer

Authors:
- Shengbo Tang
- Xihong Yuan
- Jintian Song
- Yigui Chen
- Xiaojie Tan
- Qiyun Li
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Affiliations: Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of General and Abdominal Surgery, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, P.R. China, Department of Abdominal Medicine, Fujian Cancer Hospital, Fuzhou, Fujian 350000, P.R. China, Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Abdominal Surgery, Jiangxi Provincial Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China
Published online on: October 12, 2018 https://doi.org/10.3892/ol.2018.9569
Pages: 159-164

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Abstract

The present study investigated the association between the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway with tumor progression and prognosis of colon cancer. A total of 62 patients with colon cancer were selected as the colon cancer group, and 40 patients with colon lesions were selected as the benign colon lesion group. Immunohistochemistry was used to detect the expression levels of JAK‑1 and STAT‑3 proteins in colon tissues. The association of JAK‑1 and STAT‑3 proteins with the pathological parameters and prognosis of colon cancer were analyzed. The total positive rates of JAK‑1 and STAT‑3 proteins in lesions of patients in the colon cancer group were significantly higher compared with those in the benign colon lesion group (P<0.05). The positive expression of JAK‑1 and STAT‑3 proteins in patients with colon cancer were not significantly associated with sex, age, tumor differentiation degree and neurovascular invasion (P>0.05), but significantly associated with the clinical stage of colon cancer, tumor infiltration depth and lymph node metastasis (P<0.05). The survival time of patients with colon cancer with positively‑expressed JAK‑1 and STAT‑3 proteins was significantly shorter compared with that of patients with negatively‑expressed JAK‑1 and STAT‑3 proteins (P<0.05). tumor‑node‑metastasis (TNM) stage, lymph node metastasis and the expression of JAK‑1 and STAT‑3 proteins in the tumor were associated with the prognosis of patients with colon cancer (P<0.05). TNM stage and the expression levels of JAK‑1 and STAT‑3 proteins were independent risk factors influencing the prognosis of colon cancer (P<0.05). The JAK/STAT signal may be used as a novel tumor marker and prognostic factor for the diagnosis, assessment and prognosis of colon cancer.

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