Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

Wei,Jianguo; Yang,Jianfeng; Liang,Wenqing; Xu,Chunwei; Wen,Yuanyuan

doi:10.3892/ol.2018.9609

Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

Authors:
- Jianguo Wei
- Jianfeng Yang
- Wenqing Liang
- Chunwei Xu
- Yuanyuan Wen
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Affiliations: Department of Pathology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China, Department of Radiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China, Department of Pathology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350014, P.R. China, Department of Pathology, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang 316021, P.R. China
Published online on: October 23, 2018 https://doi.org/10.3892/ol.2018.9609
Pages: 281-287
Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary thyroid leiomyosarcoma (LMS) is a rare tumor type with an unusual location, the diagnosis is based entirely on histological and immunohistochemical evaluations. In the present study, a rare case of a 74‑year‑old female patient who exhibited a right anterior neck mass for 12 months, which rapidly enlarged for the last 3 months. Ultrasound of the thyroid revealed a 55x42 mm hypoechoic mass with clear margins in the right lobe. Histological examination of the tumor demonstrated malignant spindle cells in interlacing fascicles and whorls. Additionally, nuclear pleomorphism, tumor giant cells, necrosis and abnormal mitotic figures were observed. The immunohistochemistry indicated that the tumor cells were strongly positive for smooth muscle actin, desmin, p53 and vimentin expression, but negative for cytokeratin, epithelial membrane antigen, thyroid transcription factor‑1, paired box‑8, 34βE12, cytokeratin 5/6, cluster of differentiation (CD)117, myoglobin, S100, p16. The final histopathological diagnosis was primary thyroid LMS.

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