Open Access

Novel role of microRNA‑126 in digestive system cancers: From bench to bedside (Review)

  • Authors:
    • Mingli Hu
    • Shengwei Xiong
    • Qiaofeng Chen
    • Shixuan Zhu
    • Xiaodong Zhou
  • View Affiliations

  • Published online on: October 29, 2018     https://doi.org/10.3892/ol.2018.9639
  • Pages: 31-41
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs) are ubiquitously expressed, small, non‑coding RNAs that regulate the expression of approximately 30% of the human genes at the post‑transcriptional level. miRNAs have emerged as crucial modulators in the initiation and progression of various diseases, including numerous cancer types. The high incidence rate of cancer and the large number of cancer‑associated cases of mortality are mostly due to a lack of effective treatments and biomarkers for early diagnosis. Therefore there is an urgent requirement to further understand the underlying mechanisms of tumorigenesis. MicroRNA‑126 (miR‑126) is significantly downregulated in a number of tumor types and is commonly identified as a tumor suppressor in digestive system cancers (DSCs). miR‑126 downregulates various oncogenes, including disintegrin and metalloproteinase domain‑containing protein 9, v‑crk sarcoma virus CT10 oncogene homolog and phosphoinositide‑3‑kinase regulatory subunit 2. These genes are involved in a number of tumor‑associated signaling pathways, including angiogenesis, epithelial‑mensenchymal transition and metastasis pathways. The aim of the current review was to summarize the role of miR‑126 in DSCs, in terms of its dysregulation, target genes and associated signaling pathways. In addition, the current review has discussed the potential clinical application of miR‑126 as a biomarker and therapeutic target for DSCs.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Hu M, Xiong S, Chen Q, Zhu S and Zhou X: Novel role of microRNA‑126 in digestive system cancers: From bench to bedside (Review). Oncol Lett 17: 31-41, 2019.
APA
Hu, M., Xiong, S., Chen, Q., Zhu, S., & Zhou, X. (2019). Novel role of microRNA‑126 in digestive system cancers: From bench to bedside (Review). Oncology Letters, 17, 31-41. https://doi.org/10.3892/ol.2018.9639
MLA
Hu, M., Xiong, S., Chen, Q., Zhu, S., Zhou, X."Novel role of microRNA‑126 in digestive system cancers: From bench to bedside (Review)". Oncology Letters 17.1 (2019): 31-41.
Chicago
Hu, M., Xiong, S., Chen, Q., Zhu, S., Zhou, X."Novel role of microRNA‑126 in digestive system cancers: From bench to bedside (Review)". Oncology Letters 17, no. 1 (2019): 31-41. https://doi.org/10.3892/ol.2018.9639