SNHG20 serves as a predictor for prognosis and promotes cell growth in oral squamous cell carcinoma

Gao,Pengjie; Fan,Rui; Ge,Tao

doi:10.3892/ol.2018.9709

SNHG20 serves as a predictor for prognosis and promotes cell growth in oral squamous cell carcinoma

Authors:
- Pengjie Gao
- Rui Fan
- Tao Ge
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Affiliations: Department of Stomatology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China
Published online on: November 15, 2018 https://doi.org/10.3892/ol.2018.9709
Pages: 951-957
Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Accumulating evidence indicates that long non‑coding RNAs (lncRNAs) serve important roles in various tumor types, including colorectal cancer and gastric cancer. The present study aimed to investigate the contribution of the lncRNA small nucleolar RNA host gene 20 (SNHG20) in oral squamous cell carcinoma (OSCC) progression. It was demonstrated that SNHG20 expression was significantly increased in OSCC tissue specimens, compared with in adjacent non‑tumor tissue specimens. The increased SNHG20 expression in OSCC tissue specimens was associated with tumor differentiation and Tumor‑Node‑Metastasis stage. Kaplan‑Meier analysis and log‑rank tests indicated that Higher SNHG20 expression predicted a poor overall survival (OS) rate in patients with OSCC. Multivariate Cox proportional hazards regression analysis demonstrated that increased SNHG20 expression was an independent predictor for the OS of patients with OSCC. Knockdown of SNHG20 expression in OSCC cells suppressed proliferation. The cell proliferation‑associated proteins proliferating cell nuclear antigen and Ki67 expression levels were reduced when SNHG20 was knocked down in OSCC cells; thus, the results indicated that SHNG20 may serve as a predictor and potential target for OSCC treatment.

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