Targeting the BDNF/TrkB pathway for the treatment of tumors (Review)

  • Authors:
    • Lingbin Meng
    • Baoqiong Liu
    • Rui Ji
    • Xin Jiang
    • Xuebo Yan
    • Ying Xin
  • View Affiliations

  • Published online on: December 20, 2018     https://doi.org/10.3892/ol.2018.9854
  • Pages: 2031-2039
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Abstract

Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain‑derived neurotrophic factor (BDNF), neurotrophin‑3 (NT‑3) and NT‑4. Among them, BDNF is the most studied due to its high expression in the brain. Over the past two decades, BDNF and its receptor tropomyosin receptor kinase B (TrkB) have been reported to be upregulated in a wide range of tumors. This activated signal stimulates a series of downstream pathways, including phosphoinositide 3‑kinase/protein kinase B, Ras‑Raf‑mitogen activated protein kinase kinase‑extracellular signal‑regulated kinases, the phospholipase‑C‑γ pathway and the transactivation of epidermal growth factor receptor. Activation of these signaling pathways induces oncogenic effects by increasing cancer cell growth, proliferation, survival, migration and epithelial to mesenchymal transition, and decreasing anoikis, relapse and chemotherapeutic sensitivity. The present review summarizes recent findings to discuss the role of BDNF in tumors, the underlying molecular mechanism, targeting Trk receptors for treatment of cancers and its potential risk.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Meng L, Liu B, Ji R, Jiang X, Yan X and Xin Y: Targeting the BDNF/TrkB pathway for the treatment of tumors (Review). Oncol Lett 17: 2031-2039, 2019.
APA
Meng, L., Liu, B., Ji, R., Jiang, X., Yan, X., & Xin, Y. (2019). Targeting the BDNF/TrkB pathway for the treatment of tumors (Review). Oncology Letters, 17, 2031-2039. https://doi.org/10.3892/ol.2018.9854
MLA
Meng, L., Liu, B., Ji, R., Jiang, X., Yan, X., Xin, Y."Targeting the BDNF/TrkB pathway for the treatment of tumors (Review)". Oncology Letters 17.2 (2019): 2031-2039.
Chicago
Meng, L., Liu, B., Ji, R., Jiang, X., Yan, X., Xin, Y."Targeting the BDNF/TrkB pathway for the treatment of tumors (Review)". Oncology Letters 17, no. 2 (2019): 2031-2039. https://doi.org/10.3892/ol.2018.9854