Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma

Cioplea,Mirela; Caruntu,Costin; Zurac,Sabina; Bastian,Alexandra; Sticlaru,Liana; Cioroianu,Alexandra; Boda,Daniel; Jugulete,Gheorghita; Nichita,Luciana; Popp,Cristiana

doi:10.3892/ol.2019.10097

Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma

Authors:
- Mirela Cioplea
- Costin Caruntu
- Sabina Zurac
- Alexandra Bastian
- Liana Sticlaru
- Alexandra Cioroianu
- Daniel Boda
- Gheorghita Jugulete
- Luciana Nichita
- Cristiana Popp
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Affiliations: Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania, Department of Physiology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Excellence Center in Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Infectious Diseases, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
Published online on: March 1, 2019 https://doi.org/10.3892/ol.2019.10097
Pages: 4055-4059
Copyright: © Cioplea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dendritic cells (DCs) are antigen-presenting cells with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in inflammatory benign lesions, as well as in malignant lymphoid proliferations. Density and distribution of DCs in the dermal infiltrate can be helpful to differentiate benign, reactive infiltrate from malignant nature of the lymphoid population. We performed a retrospective study including 149 patients: 35 with mycosis fungoides, 35 with spongiotic dermatitis, 35 with psoriasis, 35 with lupus and 9 with cutaneous T-cell lymphomas (other than mycosis fungoides), diagnosed using histopathological and immunohistochemical stains. Density and distribution of DCs were evaluated using specific markers (CD1a, CD11c and langerin). In all cases, numerous DCs were identified in the dermal infiltrate. Their number was significantly increased in mycosis fungoides and T-cell lymphomas and moderately increased in inflammatory lesions. Variable patterns of distribution were identified such as clusters of DCs with arachnoid extension in mycosis fungoides, nodular pattern in inflammatory lesions and dispersed distribution with peripheric accumulation in T-skin lymphomas. Therefore, immunohistochemical characterization of DC distribution can be an adjuvant tool in differential diagnosis in inflammatory dermatosis and skin lymphomas.

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