Transcriptomic model‑based lncRNAs and mRNAs serve as independent prognostic indicators in head and neck squamous cell carcinoma

Zhang,Zhi‑Li; Zhao,Li‑Jing; Xu,Lin; Chai,Liang; Wang,Feng; Xu,Ya‑Ping; Zhou,Shui‑Hong; Fu,Yong

doi:10.3892/ol.2019.10213

Transcriptomic model‑based lncRNAs and mRNAs serve as independent prognostic indicators in head and neck squamous cell carcinoma

Authors:
- Zhi‑Li Zhang
- Li‑Jing Zhao
- Lin Xu
- Liang Chai
- Feng Wang
- Ya‑Ping Xu
- Shui‑Hong Zhou
- Yong Fu
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Affiliations: Ear, Nose and Throat Department, The First Affiliated Hospital of Medical College, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, Ear, Nose and Throat Department, The Second Affiliated Hospital of Medical College, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, Ear, Nose and Throat Department, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, P.R. China
Published online on: April 4, 2019 https://doi.org/10.3892/ol.2019.10213
Pages: 5536-5544
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Head and neck squamous cell carcinoma (HNSC) is one of most common types of cancer worldwide, and mRNAs and long non‑coding RNAs (lncRNAs) have been identified as prognostic biomarkers in HNSC. In the present study, using gene expression datasets from multiple platforms, survival‑associated genes in HNSC were identified. Subsequently, a combination of 17 genes (14 mRNAs and 3 lncRNA) was optimized using random forest variable hunting and a risk score model for HNSC prognosis was developed using a cohort from The Cancer Genome Atlas. Patients with high‑risk scores tend to have earlier disease recurrence and lower survival rates, compared with those with low‑risk scores. This observation was further validated in three independent datasets (GSE41613, GSE10300 and E‑MTAB‑302). Association analysis revealed that the risk score is independent of other clinicopathological observations. On the basis of the results depicted in the nomogram, the risk score performs better in 3‑year survival rate prediction than other clinical observations. In summary, the lncRNA‑mRNA signature‑based risk score successfully predicts the survival of HNSC and serves as an indicator of prognosis.

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