Comparison of diagnostic values between CA125 combined with CA199 and ultrasound combined with CT in ovarian cancer

Guo,Bingcheng; Lian,Wei; Liu,Shuai; Cao,Yingchun; Liu,Jianhua

doi:10.3892/ol.2019.10264

Comparison of diagnostic values between CA125 combined with CA199 and ultrasound combined with CT in ovarian cancer

Authors:
- Bingcheng Guo
- Wei Lian
- Shuai Liu
- Yingchun Cao
- Jianhua Liu
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Affiliations: Department of Ultrasound, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, CT Room, Yantaishan Hospital of Yantai, Yantai, Shandong 264001, P.R. China, Department of Urology Surgery, People's Hospital of Zhangqiu District, Jinan, Shandong 250200, P.R. China, Department of Neurology, People's Hospital of Zhangqiu District, Jinan, Shandong 250200, P.R. China, Clinical Laboratory, The 5th People's Hospital of Jinan, Jinan, Shandong 250000, P.R. China
Published online on: April 18, 2019 https://doi.org/10.3892/ol.2019.10264
Pages: 5523-5528

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Abstract

Application values of CA125 combined with CA199 and ultrasound combined with computed tomography (CT) in the clinical diagnosis of ovarian cancer were compared. A retrospective analysis was performed on 168 ovarian cancer patients admitted to the Department of Gynecology in Jining No.1 People's Hospital from July 2013 to March 2016. Of the patients 107 with malignant tumors were in the malignant group, and 61 patients with benign tumors were in the benign group. Another 98 healthy controls in the same period were in the normal group. Chemiluminescence was used for the detection of levels of tumor markers CA125 and CA199 in the serum of all patients. CA125 combined with CA199 and color Doppler ultrasound combined with CT scan were used to diagnose and analyze the sensitivity, specificity, accuracy, and positive detection rate of ovarian cancer patients at different stages. The sensitivity, specificity and diagnostic coincidence rate of ultrasound combined with CT in the diagnosis of ovarian cancer were 97.20, 80.32 and 91.07%, respectively, which were significantly higher than the 92.52, 73.77 and 85.71% of serum CA125 combined with CA199. The positive detection rate of ultrasound combined with CT in the early diagnosis of ovarian cancer was 93.55%, higher than 83.87% of CA125 combined with CA199. The sensitivity, specificity, coincidence rate and positive detection rate of ultrasound combined with CT in the diagnosis were higher than those of CA125 combined with CA199. In the actual diagnosis process, these two diagnostic schemes can be selectively and comprehensively applied, so as to make a correct diagnosis, which is of great significance for reducing patient mortality.

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