miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1

  • Authors:
    • Zhe Jin
    • Baoxing Jia
    • Ludong Tan
    • Yahui Liu
  • View Affiliations

  • Published online on: April 24, 2019     https://doi.org/10.3892/ol.2019.10280
  • Pages: 314-320
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Abstract

MicroRNAs, considered as a promising focus for the treatment of tumors, are key regulators of a large number of genes. The aim of the present study was to investigate the biological functions of microRNA (miR)‑330‑3p in liver cancer as it had been identified previously that miR‑330‑3p was deregulated in liver cancer. In order to identify the function of miR‑330‑3p in liver cancer, the expression of miR‑330‑3p was determined in liver cancer tissues and adjacent non‑tumor tissues using reverse transcription‑quantitative polymerase chain reaction analysis. To elucidate the function of miR‑330‑3p in liver cancer, miR‑330‑3p was overexpressed using mimic transfection. Cell migration was inhibited by miR‑330‑3p in liver cancer cells. The miRNA target prediction databases were used to identify potential target genes of miR‑330‑3p in liver cancer. The RNA level of mitogen‑activated protein kinase kinase 1 (MAP2K1) was downregulated by miR‑330‑3p in liver cancer cells. In conclusion, miR‑330‑3p suppresses cell migration by targeting MAP2K1 in liver cancer cells.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Jin Z, Jia B, Tan L and Liu Y: miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1. Oncol Lett 18: 314-320, 2019.
APA
Jin, Z., Jia, B., Tan, L., & Liu, Y. (2019). miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1. Oncology Letters, 18, 314-320. https://doi.org/10.3892/ol.2019.10280
MLA
Jin, Z., Jia, B., Tan, L., Liu, Y."miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1". Oncology Letters 18.1 (2019): 314-320.
Chicago
Jin, Z., Jia, B., Tan, L., Liu, Y."miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1". Oncology Letters 18, no. 1 (2019): 314-320. https://doi.org/10.3892/ol.2019.10280