Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma

Liu,Ning; Qu,Feng; Wei,Kang; Gan,Weidong; Wang,Zhen; Zhuang,Wenyuan; Agizamhan,Sezim; Ma,Wenliang; Yang,Jun; Chen,Ming; Xu,Linfeng; Guo,Hongqian; Li,Dongmei

doi:10.3892/ol.2019.10305

Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma

Authors:
- Ning Liu
- Feng Qu
- Kang Wei
- Weidong Gan
- Zhen Wang
- Wenyuan Zhuang
- Sezim Agizamhan
- Wenliang Ma
- Jun Yang
- Ming Chen
- Linfeng Xu
- Hongqian Guo
- Dongmei Li
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Affiliations: Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Immunology and Reproduction Biology Laboratory and State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University Medical School, Nanjing, Jiangsu 210093, P.R. China
Published online on: May 3, 2019 https://doi.org/10.3892/ol.2019.10305
Pages: 472-478

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Abstract

The aim of the present study was to investigate the incidence and significance of psammoma bodies (PBs) in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) and papillary renal cell carcinoma (PRCC). The presence of PBs, irregular calcifications, hyaline globules and nested architecture in RCC tissues, which included 47 cases of Xp11.2 tRCC and 95 cases of PRCC, was examined by two pathologists. Compared with PRCC, patients with Xp11.2 tRCC exhibited a higher frequency of PBs, hyaline globules and nested architecture. The presence of PBs in combination with the occurrence of a nested architecture achieved a specificity of 93.7% when diagnosing Xp11.2 tRCC. However, there were no significant differences in the overall survival between patients with and without PBs in both types of RCC. Therefore, the presence of PBs combined with nested architecture may provide guidance for the diagnosis of Xp11.2 tRCC; however, PBs cannot predict tumor behavior in Xp11.2 tRCC or PRCC.

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