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Usefulness of percutaneous microwave ablation for large non‑small cell lung cancer: A preliminary report

  • Authors:
    • Claudio Pusceddu
    • Luca Melis
    • Barbara Sotgia
    • Daniela Guerzoni
    • Alberto Porcu
    • Alessandro Fancellu

  • View Affiliations

  • Published online on: May 20, 2019     https://doi.org/10.3892/ol.2019.10375
  • Pages: 659-666

  • Copyright: © Pusceddu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The role of microwave ablation (MWA) in patients with non‑small cell lung cancer (NSCLC) remains ill‑defined. This retrospective study evaluated the oncological outcomes of CT-guided MWA in patients with large NSCLC. Kaplan‑Meier analysis was used to evaluate overall survival (OS) and cancer‑specific survival (CSS). The log‑rank test was used to compare survival between patients with an NSCLC size greater or smaller than 4 cm. The likelihood of local tumor progression (LTP) was analyzed using a multivariable regression model. A total of 53 patients with 65 tumors were analyzed. The mean tumor size was 5.0±1.8 cm. At the 1‑month CT scan, complete tumor ablation was observed in 44.6% of cases. In 18.5% of cases a redo‑MWA session was carried out, while in 4.6%, a third MWA was necessary to obtain complete tumor necrosis. The mean follow‑up was 28.1±20.6 months with a median duration of 21.5 months. The 1‑year, 2‑year, 3‑year and 5‑year OS rates were 78.2, 48.3, 34.8 and 18.3%, respectively. The median CSS was 25 months (95% CI 15.5‑34.5). The 1‑year, 2‑year, 3‑year and 5‑year CSS rates were 84.3, 53.7, 42.1 and 30.0%, respectively. OS in patients with tumor size ≥4 cm was significantly lower when compared with those having smaller tumors (P=0.03). LTP was observed in 19 patients (35.8%). Incomplete tumor ablation [odds ratio (OR) 6.57; P<0.05] and tumor size ≥4 cm (OR 0.18; P<0.05) were significant independent predictors of LTP. In conclusion, CT‑guided MWA may represent a useful tool in the multimodality treatment of patients with large advanced NSCLC.
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July-2019
Volume 18 Issue 1

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Spandidos Publications style
Pusceddu C, Melis L, Sotgia B, Guerzoni D, Porcu A and Fancellu A: Usefulness of percutaneous microwave ablation for large non‑small cell lung cancer: A preliminary report. Oncol Lett 18: 659-666, 2019.
APA
Pusceddu, C., Melis, L., Sotgia, B., Guerzoni, D., Porcu, A., & Fancellu, A. (2019). Usefulness of percutaneous microwave ablation for large non‑small cell lung cancer: A preliminary report. Oncology Letters, 18, 659-666. https://doi.org/10.3892/ol.2019.10375
MLA
Pusceddu, C., Melis, L., Sotgia, B., Guerzoni, D., Porcu, A., Fancellu, A."Usefulness of percutaneous microwave ablation for large non‑small cell lung cancer: A preliminary report". Oncology Letters 18.1 (2019): 659-666.
Chicago
Pusceddu, C., Melis, L., Sotgia, B., Guerzoni, D., Porcu, A., Fancellu, A."Usefulness of percutaneous microwave ablation for large non‑small cell lung cancer: A preliminary report". Oncology Letters 18, no. 1 (2019): 659-666. https://doi.org/10.3892/ol.2019.10375