Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol

  • Authors:
    • Daqing Wang
    • Qianqian Hou
    • Lingjun Zhao
    • Jun Gao
    • Yang Xiao
    • Anhua Wang
  • View Affiliations

  • Published online on: May 27, 2019     https://doi.org/10.3892/ol.2019.10398
  • Pages: 1402-1408
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Abstract

Drug resistance and disease relapse are still challenging problems in the chemotherapy of colorectal cancer (CRC). Programmed cell death factor 4 (PDCD4) has previously been reported to act as a tumor suppressor and was implicated in the chemosensitivity of numerous types of human malignancy. In this study, the effect of PDCD4 in the sensitivity of CRC to the chemotherapy drug Taxol was investigated. The results confirmed that lower PDCD4 expression was present in CRC tumor tissues, when compared with in normal adjacent tissues (p) and closely associated with the prognosis of patients with CRC. Upregulation of PDCD4 significantly enhanced the sensitivity of CRC cells to Taxol, by partially contributing to pro‑apoptosis and anti‑invasion pathways, both through upregulation of the apoptosis‑associated protein Bax, and downregulation of the anti‑apoptosis protein Bcl‑2 and invasion‑associated proteins MMP‑9. These findings might present a novel strategy for sensitizing tumor cells to apoptosis and, thus, overcoming chemotherapy resistance in CRC.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang D, Hou Q, Zhao L, Gao J, Xiao Y and Wang A: Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol. Oncol Lett 18: 1402-1408, 2019.
APA
Wang, D., Hou, Q., Zhao, L., Gao, J., Xiao, Y., & Wang, A. (2019). Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol. Oncology Letters, 18, 1402-1408. https://doi.org/10.3892/ol.2019.10398
MLA
Wang, D., Hou, Q., Zhao, L., Gao, J., Xiao, Y., Wang, A."Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol". Oncology Letters 18.2 (2019): 1402-1408.
Chicago
Wang, D., Hou, Q., Zhao, L., Gao, J., Xiao, Y., Wang, A."Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol". Oncology Letters 18, no. 2 (2019): 1402-1408. https://doi.org/10.3892/ol.2019.10398