Open Access

MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer

  • Authors:
    • Longyang Liu
    • Juanjuan Yi
    • Xiaojie Deng
    • Jianhuan Yuan
    • Beixian Zhou
    • Zhongqiu Lin
    • Zhaoyang Zeng
  • View Affiliations

  • Published online on: May 27, 2019     https://doi.org/10.3892/ol.2019.10406
  • Pages: 1049-1056
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the expression of myosin 9 (MYH9) in epithelial ovarian cancer and to explore its correlation with the clinicopathological parameters and prognosis of epithelial ovarian cancer (EOC). A total of 265 cases of paraffin‑embedded ovarian cancer tissues and 41 paratumor tissues which had been pathologically confirmed at the Memorial Hospital of Sun Yat‑sen University from 2009 to 2017 were included in the present study. MYH9 expression was investigated with immunohistochemistry using a polyclonal antibody specific for MYH9. MYH9 expression is associated with disease progression free and overall survival in epithelial ovarian cancer patients; and the expression of MYH9 is associated with International Federation of Gynecology and Obstetrics stage, lymph node metastasis, intraperitoneal metastasis, survival status (at last follow‑up), intraperitoneal recurrence, residual tumor size and ascites with tumor cells. Moreover, in a multivariate model MYH9 overexpression was an independent predictor of poor survival in epithelial ovarian cancer. MYH9 may be a candidate that plays a oncogenic role in epithelial ovarian cancer. MYH9 is a useful independent prognostic marker in epithelial ovarian cancer, and it may provide a candidate target therapy treatment of ovarian cancer in the future.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu L, Yi J, Deng X, Yuan J, Zhou B, Lin Z and Zeng Z: MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer. Oncol Lett 18: 1049-1056, 2019.
APA
Liu, L., Yi, J., Deng, X., Yuan, J., Zhou, B., Lin, Z., & Zeng, Z. (2019). MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer. Oncology Letters, 18, 1049-1056. https://doi.org/10.3892/ol.2019.10406
MLA
Liu, L., Yi, J., Deng, X., Yuan, J., Zhou, B., Lin, Z., Zeng, Z."MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer". Oncology Letters 18.2 (2019): 1049-1056.
Chicago
Liu, L., Yi, J., Deng, X., Yuan, J., Zhou, B., Lin, Z., Zeng, Z."MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer". Oncology Letters 18, no. 2 (2019): 1049-1056. https://doi.org/10.3892/ol.2019.10406