Open Access

Fusobacterium nucleatum‑positive colorectal cancer (Review)

  • Authors:
    • Zhenhua Yang
    • Guang Ji
  • View Affiliations

  • Published online on: June 4, 2019     https://doi.org/10.3892/ol.2019.10433
  • Pages: 975-982
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is an important threat to human health and the fourth leading cause of mortality worldwide. Accumulating evidence indicates that the composition of the intestinal flora is associated with the occurrence of CRC. Fusobacterium nucleatum (Fn), one of the highly enriched bacteria in CRC tissues, invades the mucosa with adhesion factors and virulence proteins, interacts with the host immune system and promotes the occurrence and development of CRC and chemoresistance. Fn infection is prevalent in human colorectal carcinoma, although the infection rate varies in different regions. Fn may be used as a prognostic indicator of CRC. It is important to understand the multi‑pathway carcinogenic mechanisms associated with CRC in order to develop novel antibacterial drugs against Fn. The current review summarizes the role of Fn and relevant research concerning CRC published in recent years, focusing on Fn infection in CRC, pathogenesis of Fn, Fn‑positive CRC treatment, screening and prevention strategies against Fn‑positive CRC.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang Z and Ji G: Fusobacterium nucleatum‑positive colorectal cancer (Review). Oncol Lett 18: 975-982, 2019.
APA
Yang, Z., & Ji, G. (2019). Fusobacterium nucleatum‑positive colorectal cancer (Review). Oncology Letters, 18, 975-982. https://doi.org/10.3892/ol.2019.10433
MLA
Yang, Z., Ji, G."Fusobacterium nucleatum‑positive colorectal cancer (Review)". Oncology Letters 18.2 (2019): 975-982.
Chicago
Yang, Z., Ji, G."Fusobacterium nucleatum‑positive colorectal cancer (Review)". Oncology Letters 18, no. 2 (2019): 975-982. https://doi.org/10.3892/ol.2019.10433