Fusobacterium nucleatum‑positive colorectal cancer (Review)
- Authors:
- Zhenhua Yang
- Guang Ji
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Affiliations: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China - Published online on: June 4, 2019 https://doi.org/10.3892/ol.2019.10433
- Pages: 975-982
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Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. 66:683–691. 2017. View Article : Google Scholar : PubMed/NCBI | |
Center MM, Jemal A, Smith RA and Ward E: Worldwide variations in colorectal cancer. CA Cancer J Clin. 59:366–378. 2009. View Article : Google Scholar : PubMed/NCBI | |
Zheng R, Zeng H, Zhang S, Chen T and Chen W: National estimates of cancer prevalence in China, 2011. Cancer Lett. 370:33–38. 2016. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI | |
Berg A: Nutrition, development, and population growth. Popul Bull. 29:3–37. 1973.PubMed/NCBI | |
Alsheridah N and Akhtar S: Diet, obesity and colorectal carcinoma risk: Results from a national cancer registry-based middle-eastern study. BMC Cancer. 18:12272018. View Article : Google Scholar : PubMed/NCBI | |
Mafiana RN, Al Lawati AS, Waly MI, Al Farsi Y, Al Kindi M and Al Moundhri M: Association between dietary and lifestyle indices and colorectal cancer in Oman: A case-control study. Asian Pac J Cancer Prev. 19:3117–3122. 2018. View Article : Google Scholar : PubMed/NCBI | |
Markowitz SD and Bertagnolli MM: Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med. 361:2449–2460. 2009. View Article : Google Scholar : PubMed/NCBI | |
Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S and Tabernero J: Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 17:2682017. View Article : Google Scholar : PubMed/NCBI | |
Brower V: Connecting viruses to cancer: How research moves from association to causation. J Natl Cancer Inst. 96:256–257. 2004. View Article : Google Scholar : PubMed/NCBI | |
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, . Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum. 100:1–441. 2012. | |
Tremaroli V and Bäckhed F: Functional interactions between the gut microbiota and host metabolism. Nature. 489:242–249. 2012. View Article : Google Scholar : PubMed/NCBI | |
Yamashiro Y: Gut microbiota in health and disease. Ann Nutr Metab. 71:242–246. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sears CL and Garrett WS: Microbes, microbiota, and colon cancer. Cell Host Microbe. 15:317–328. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, et al: Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22:292–298. 2012. View Article : Google Scholar : PubMed/NCBI | |
Repass J, Maherali N and Owen K; Reproducibility Project, : Cancer Biology; Reproducibility Project Cancer Biology: Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. ELife. 5(pii): e100122016. View Article : Google Scholar : PubMed/NCBI | |
Yamamura K, Baba Y, Miyake K, Nakamura K, Shigaki H, Mima K, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, et al: Fusobacterium nucleatum in gastroenterological cancer: Evaluation of measurement methods using quantitative polymerase chain reaction and a literature review. Oncol Lett. 14:6373–6378. 2017.PubMed/NCBI | |
Han YW: Fusobacterium nucleatum: A commensal-turned pathogen. Curr Opin Microbiol. 23:141–147. 2015. View Article : Google Scholar : PubMed/NCBI | |
Yamaoka Y, Suehiro Y, Hashimoto S, Hoshida T, Fujimoto M, Watanabe M, Imanaga D, Sakai K, Matsumoto T, Nishioka M, et al: Fusobacterium nucleatum as a prognostic marker of colorectal cancer in a Japanese population. J Gastroenterol. 53:517–524. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ramos A and Hemann MT: Drugs, Bugs, and Cancer: Fusobacterium nucleatum promotes chemoresistance in colorectal cancer. Cell. 170:411–413. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Yang Y, Weng W, Guo B, Cai G, Ma Y and Cai S: Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expressio n in colorectal cancer. J Exp Clin Cancer Res. 38:142019. View Article : Google Scholar : PubMed/NCBI | |
Han YW, Shi W, Huang GT, Kinder Haake S, Park NH, Kuramitsu H and Genco RJ: Interactions between periodontal bacteria and human oral epithelial cells: Fusobacterium nucleatum adheres to and invades epithelial cells. Infect Immun. 68:3140–3146. 2000. View Article : Google Scholar : PubMed/NCBI | |
Heckmann JG, Lang CJ, Hartl H and Tomandl B: Multiple brain abscesses caused by Fusobacterium nucleatum treated conservatively. Can J Neurol Sci. 30:266–268. 2003. View Article : Google Scholar : PubMed/NCBI | |
Han YW, Fardini Y, Chen C, Iacampo KG, Peraino VA, Shamonki JM and Redline RW: Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol. 115:442–445. 2010. View Article : Google Scholar : PubMed/NCBI | |
Wells CD, Balan V and Smilack JD: Pyogenic liver abscess after colonoscopy in a patient with ulcerative colitis. Clin Gastroenterol Hepatol. 3:xxiv2005. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Buhimschi CS, Temoin S, Bhandari V, Han YW and Buhimschi IA: Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis. PLoS One. 8:e561312013. View Article : Google Scholar : PubMed/NCBI | |
Hill GB: Investigating the source of amniotic fluid isolates of fusobacteria. Clin Infect Dis. 16 (Suppl 4):S423–S424. 1993. View Article : Google Scholar : PubMed/NCBI | |
Han YW, Redline RW, Li M, Yin L, Hill GB and McCormick TS: Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: Implication of oral bacteria in preterm birth. Infect Immun. 72:2272–2279. 2004. View Article : Google Scholar : PubMed/NCBI | |
Han YW: Can oral bacteria cause pregnancy complications? Womens Health (Lond). 7:401–404. 2011. View Article : Google Scholar : PubMed/NCBI | |
Han YW: Oral health and adverse pregnancy outcomes-what's next? J Dent Res. 90:289–293. 2011. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Redline RW and Han YW: Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response. J Immunol. 179:2501–2508. 2007. View Article : Google Scholar : PubMed/NCBI | |
Bachrach G, Ianculovici C, Naor R and Weiss EI: Fluorescence based measurements of Fusobacterium nucleatum coaggregation and of fusobacterial attachment to mammalian cells. FEMS Microbiol Lett. 248:235–240. 2005. View Article : Google Scholar : PubMed/NCBI | |
Shang FM and Liu HL: Fusobacterium nucleatum and colorectal cancer: A review. World J Gastrointest Oncol. 10:71–81. 2018. View Article : Google Scholar : PubMed/NCBI | |
Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, Barnes R, Watson P, Allen-Vercoe E, Moore RA and Holt RA: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 22:299–306. 2012. View Article : Google Scholar : PubMed/NCBI | |
Li YY, Ge QX, Cao J, Zhou YJ, Du YL, Shen B, Wan YJ and Nie YQ: Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients. World J Gastroenterol. 22:3227–3233. 2016. View Article : Google Scholar : PubMed/NCBI | |
Mima K, Sukawa Y, Nishihara R, Qian ZR, Yamauchi M, Inamura K, Kim SA, Masuda A, Nowak JA, Nosho K, et al: Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol. 1:653–661. 2015. View Article : Google Scholar : PubMed/NCBI | |
Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, et al: Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol. 22:557–566. 2016. View Article : Google Scholar : PubMed/NCBI | |
Mima K, Cao Y, Chan AT, Qian ZR, Nowak JA, Masugi Y, Shi Y, Song M, da Silva A, Gu M, et al: Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location. Clin Transl Gastroenterol. 7:e2002016. View Article : Google Scholar : PubMed/NCBI | |
Komiya Y, Shimomura Y, Higurashi T, Sugi Y, Arimoto J, Umezawa S, Uchiyama S, Matsumoto M and Nakajima A: Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity. Gut. Jun 22–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI | |
Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, et al: Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 358:1443–1448. 2017. View Article : Google Scholar : PubMed/NCBI | |
McCoy AN, Araújo-Pérez F, Azcárate-Peril A, Yeh JJ, Sandler RS and Keku TO: Fusobacterium is associated with colorectal adenomas. PLoS One. 8:e536532013. View Article : Google Scholar : PubMed/NCBI | |
Amitay EL and Brenner H: Response to comments on ‘Fusobacterium and colorectal cancer: Causal factor or passenger? Results from a large colorectal cancer screening study’. Carcinogenesis. 39:852018. View Article : Google Scholar : PubMed/NCBI | |
Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, et al: Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway. Int J Cancer. 137:1258–1268. 2015. View Article : Google Scholar : PubMed/NCBI | |
Koi M, Okita Y and Carethers JM: Fusobacterium nucleatum infection in colorectal cancer: Linking inflammation, DNA mismatch repair and genetic and epigenetic alterations. J Anus Rectum Colon. 2:37–46. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Cai S and Ma Y: Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. J Cancer. 9:1652–1659. 2018. View Article : Google Scholar : PubMed/NCBI | |
Coppenhagen-Glazer S, Sol A, Abed J, Naor R, Zhang X, Han YW and Bachrach G: Fap2 of Fusobacterium nucleatum is a galactose-inhibitable adhesin involved in coaggregation, cell adhesion, and preterm birth. Infect Immun. 83:1104–1113. 2015. View Article : Google Scholar : PubMed/NCBI | |
West NR, McCuaig S, Franchini F and Powrie F: Emerging cytokine networks in colorectal cancer. Nat Rev Immunol. 15:615–629. 2015. View Article : Google Scholar : PubMed/NCBI | |
Aggarwal BB, Vijayalekshmi RV and Sung B: Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe. Clin Cancer Res. 15:425–430. 2009. View Article : Google Scholar : PubMed/NCBI | |
Balkwill FR and Mantovani A: Cancer-related inflammation: Common themes and therapeutic opportunities. Semin Cancer Biol. 22:33–40. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, et al: Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 14:207–215. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ma N, Liu Q, Hou L, Wang Y and Liu Z: MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer. Int J Immunopathol Pharmacol. 30:152–162. 2017. View Article : Google Scholar : PubMed/NCBI | |
Gabrilovich DI, Ostrand-Rosenberg S and Bronte V: Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 12:253–268. 2012. View Article : Google Scholar : PubMed/NCBI | |
Qian BZ and Pollard JW: Macrophage diversity enhances tumor progression and metastasis. Cell. 141:39–51. 2010. View Article : Google Scholar : PubMed/NCBI | |
Gabrilovich DI and Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 9:162–174. 2009. View Article : Google Scholar : PubMed/NCBI | |
Quah SY, Bergenholtz G and Tan KS: Fusobacterium nucleatum induces cytokine production through Toll-like-receptor-independent mechanism. Int Endod J. 47:550–559. 2014. View Article : Google Scholar : PubMed/NCBI | |
Dharmani P, Strauss J, Ambrose C, Allen-Vercoe E and Chadee K: Fusobacterium nucleatum infection of colonic cells stimulates MUC2 mucin and tumor necrosis factor alpha. Infect Immun. 79:2597–2607. 2011. View Article : Google Scholar : PubMed/NCBI | |
Trinchieri G: Cancer and inflammation: An old intuition with rapidly evolving new concepts. Annu Rev Immunol. 30:677–706. 2012. View Article : Google Scholar : PubMed/NCBI | |
Taniguchi K and Karin M: NF-κB, inflammation, immunity and cancer: Coming of age. Nat Rev Immunol. 18:309–324. 2018. View Article : Google Scholar : PubMed/NCBI | |
Fardini Y, Wang X, Témoin S, Nithianantham S, Lee D, Shoham M and Han YW: Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol. 82:1468–1480. 2011. View Article : Google Scholar : PubMed/NCBI | |
Han YW, Ikegami A, Rajanna C, Kawsar HI, Zhou Y, Li M, Sojar HT, Genco RJ, Kuramitsu HK and Deng CX: Identification and characterization of a novel adhesin unique to oral fusobacteria. J Bacteriol. 187:5330–5340. 2005. View Article : Google Scholar : PubMed/NCBI | |
Xu M, Yamada M, Li M, Liu H, Chen SG and Han YW: FadA from Fusobacterium nucleatum utilizes both secreted and nonsecreted forms for functional oligomerization for attachment and invasion of host cell. J Biol Chem. 282:25000–25009. 2007. View Article : Google Scholar : PubMed/NCBI | |
Temoin S, Wu KL, Wu V, Shoham M and Han YW: Signal peptide of FadA adhesin from Fusobacterium nucleatum plays a novel structural role by modulating the filament's length and width. FEBS Lett. 586:1–6. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rubinstein MR, Wang X, Liu W, Hao Y, Cai G and Han YW: Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 14:195–206. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Peng Y, Yu J, Chen T, Wu Y, Shi L, Li Q, Wu J and Fu X: Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade. Oncotarget. 8:31802–31814. 2017.PubMed/NCBI | |
Wu Y, Wu J, Chen T, Li Q, Peng W, Li H, Tang X and Fu X: Fusobacterium nucleatum potentiates intestinal tumorigenesis in mice via a Toll-like receptor 4/p21-activated kinase 1 cascade. Dig Dis Sci. 63:1210–1218. 2018. View Article : Google Scholar : PubMed/NCBI | |
Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, et al: Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Semin Cancer Biol. 35 (Suppl):S244–S275. 2015. View Article : Google Scholar : PubMed/NCBI | |
Abed J, Emgård JE, Zamir G, Faroja M, Almogy G, Grenov A, Sol A, Naor R, Pikarsky E, Atlan KA, et al: Fap2 Mediates Fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed Gal-GalNAc. Cell Host Microbe. 20:215–225. 2016. View Article : Google Scholar : PubMed/NCBI | |
Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, Enk J, Bar-On Y, Stanietsky-Kaynan N, Coppenhagen-Glazer S, et al: Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity. 42:344–355. 2015. View Article : Google Scholar : PubMed/NCBI | |
Shenker BJ and Datar S: Fusobacterium nucleatum inhibits human T-cell activation by arresting cells in the mid-G1 phase of the cell cycle. Infect Immun. 63:4830–4836. 1995.PubMed/NCBI | |
Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, et al: Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating Toll-like receptor 4 signaling to nuclear factor-κB, and up-regulating expression of microRNA-21. Gastroenterology. 152:851–866.e24. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tahara T, Yamamoto E, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, An B, et al: Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res. 74:1311–1318. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mima K, Nishihara R, Qian ZR, Cao Y, Sukawa Y, Nowak JA, Yang J, Dou R, Masugi Y, Song M, et al: Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 65:1973–1980. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ryuk JP, Choi GS, Park JS, Kim HJ, Park SY, Yoon GS, Jun SH and Kwon YC: Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection. Ann Surg Treat Res. 86:143–151. 2014. View Article : Google Scholar : PubMed/NCBI | |
Cartwright TH: Treatment decisions after diagnosis of metastatic colorectal cancer. Clin Colorectal Cancer. 11:155–166. 2012. View Article : Google Scholar : PubMed/NCBI | |
Yu T, Guo F, Yu Y, Sun T, Ma D, Han J, Qian Y, Kryczek I, Sun D, Nagarsheth N, et al: Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell. 170:548–563.e16. 2017. View Article : Google Scholar : PubMed/NCBI | |
Lasry A, Zinger A and Ben-Neriah Y: Inflammatory networks underlying colorectal cancer. Nat Immunol. 17:230–240. 2016. View Article : Google Scholar : PubMed/NCBI | |
Huang WW, Hsieh KP, Huang RY and Yang YH: Role of cyclooxygenase-2 inhibitors in the survival outcome of colorectal cancer patients: A population-based cohort study. Kaohsiung J Med Sci. 33:308–314. 2017. View Article : Google Scholar : PubMed/NCBI | |
Williams CS, Shattuck-Brandt RL and DuBois RN: The role of COX-2 in intestinal cancer. Expert Opin Investig Drugs. 8:1–12. 1999. View Article : Google Scholar : PubMed/NCBI | |
Waddell WR, Ganser GF, Cerise EJ and Loughry RW: Sulindac for polyposis of the colon. Am J Surg. 157:175–179. 1989. View Article : Google Scholar : PubMed/NCBI | |
Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP and Meade TW: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 376:1741–1750. 2010. View Article : Google Scholar : PubMed/NCBI | |
Tsoi KK, Chan FC, Hirai HW and Sung JJ: Risk of gastrointestinal bleeding and benefit from colorectal cancer reduction from long-term use of low-dose aspirin: A retrospective study of 612 509 patients. J Gastroenterol Hepatol. 33:1728–1736. 2018. View Article : Google Scholar : PubMed/NCBI | |
Johnson CC, Jankowski M, Rolnick S, Yood MU and Alford SH: Influence of NSAID use among colorectal cancer survivors on cancer outcomes. Am J Clin Oncol. 40:370–374. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, Petrelli N, Pipas JM, Karp DD, Loprinzi CL, et al: A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 348:883–890. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ng K, Meyerhardt JA, Chan AT, Sato K, Chan JA, Niedzwiecki D, Saltz LB, Mayer RJ, Benson AB III, Schaefer PL, et al: Aspirin and COX-2 inhibitor use in patients with stage III colon cancer. J Natl Cancer Inst. 107:3452014.PubMed/NCBI | |
Bos CL, Kodach LL, van den Brink GR, Diks SH, van Santen MM, Richel DJ, Peppelenbosch MP and Hardwick JC: Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 25:6447–6456. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ma X, Aoki T, Tsuruyama T and Narumiya S: Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment that amplify inflammation and tumor growth. Cancer Res. 75:2822–2832. 2015. View Article : Google Scholar : PubMed/NCBI | |
Haak BW, Lankelma JM, Hugenholtz F, Belzer C, de Vos WM and Wiersinga WJ: Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans. J Antimicrob Chemother. 74:782–786. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yu YN, Yu TC, Zhao HJ, Sun TT, Chen HM, Chen HY, An HF, Weng YR, Yu J, Li M, et al: Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment. Oncotarget. 6:32013–32026. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bever KM and Le DT: An expanding role for immunotherapy in colorectal cancer. J Natl Compr Canc Netw. 15:401–410. 2017. View Article : Google Scholar : PubMed/NCBI | |
Bhatt AP, Redinbo MR and Bultman SJ: The role of the microbiome in cancer development and therapy. CA Cancer J Clin. 67:326–344. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chakravarty D, Gao J, Phillips SM, Kundra R, Zhang H, Wang J, Rudolph JE, Yaeger R, Soumerai T, Nissan MH, et al: OncoKB: A precision oncology knowledge base. JCO Precis Oncol 2017. 2017. View Article : Google Scholar | |
Cramer P and Bresalier RS: Gastrointestinal and hepatic complications of immune checkpoint inhibitors. Curr Gastroenterol Rep. 19:32017. View Article : Google Scholar : PubMed/NCBI | |
Nedaeinia R, Sharifi M, Avan A, Kazemi M, Nabinejad A, Ferns GA, Ghayour-Mobarhan M and Salehi R: Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4. Tumour Biol. 39:10104283176922612017. View Article : Google Scholar : PubMed/NCBI | |
Kumar A, Thotakura PL, Tiwary BK and Krishna R: Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen protein-protein interactions. BMC Microbiol. 16:842016. View Article : Google Scholar : PubMed/NCBI | |
Brook I and Frazier EH: Immune response to Fusobacterium nucleatum and Prevotella intermedia in the sputum of patients with acute exacerbation of chronic bronchitis. Chest. 124:832–833. 2003. View Article : Google Scholar : PubMed/NCBI | |
Velsko IM, Chukkapalli SS, Rivera-Kweh MF, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR and Kesavalu L: Fusobacterium nucleatum alters atherosclerosis risk factors and enhances inflammatory markers with an atheroprotective immune response in ApoE(null) mice. PLoS One. 10:e01297952015. View Article : Google Scholar : PubMed/NCBI | |
Wang HF, Li LF, Guo SH, Zeng QY, Ning F, Liu WL and Zhang G: Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer. Sci Rep. 6:334402016. View Article : Google Scholar : PubMed/NCBI | |
Hundt S, Haug U and Brenner H: Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med. 150:162–169. 2009. View Article : Google Scholar : PubMed/NCBI | |
Wong SH, Kwong TNY, Chow TC, Luk AKC, Dai RZW, Nakatsu G, Lam TYT, Zhang L, Wu JCY, Chan FKL, et al: Quantitation of faecal Fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia. Gut. 66:1441–1448. 2017. View Article : Google Scholar : PubMed/NCBI | |
Huang S, Yang Z, Zou D, Dong D, Liu A, Liu W and Huang L: Rapid detection of nusG and fadA in Fusobacterium nucleatum by loop-mediated isothermal amplification. J Med Microbiol. 65:760–769. 2016. View Article : Google Scholar : PubMed/NCBI | |
Song M, Garrett WS and Chan AT: Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 148:1244–1260.e16. 2015. View Article : Google Scholar : PubMed/NCBI | |
Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, Overvad K, Olsen A, Tjønneland A, Clavel F, et al: Meat, fish, and colorectal cancer risk: The European prospective investigation into cancer and nutrition. J Natl Cancer Inst. 97:906–916. 2005. View Article : Google Scholar : PubMed/NCBI | |
Larsson SC and Wolk A: Meat consumption and risk of colorectal cancer: A meta-analysis of prospective studies. Int J Cancer. 119:2657–2664. 2006. View Article : Google Scholar : PubMed/NCBI | |
Magalhães B, Peleteiro B and Lunet N: Dietary patterns and colorectal cancer: Systematic review and meta-analysis. Eur J Cancer Prev. 21:15–23. 2012. View Article : Google Scholar : PubMed/NCBI | |
David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al: Diet rapidly and reproducibly alters the human gut microbiome. Nature. 505:559–563. 2014. View Article : Google Scholar : PubMed/NCBI | |
Xu Z and Knight R: Dietary effects on human gut microbiome diversity. Br J Nutr. 113 (Suppl):S1–S5. 2015. View Article : Google Scholar : PubMed/NCBI | |
Haro C, García-Carpintero S, Rangel-Zúñiga OA, Alcalá-Díaz JF, Landa BB, Clemente JC, Pérez-Martínez P, López-Miranda J, Pérez-Jiménez F and Camargo A: Consumption of two healthy dietary patterns restored microbiota dysbiosis in obese patients with metabolic dysfunction. Mol Nutr Food Res. 61:2017. View Article : Google Scholar | |
Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS and Sonnenburg JL: Diet-induced extinctions in the gut microbiota compound over generations. Nature. 529:212–215. 2016. View Article : Google Scholar : PubMed/NCBI | |
Tabung FK, Liu L, Wang W, Fung TT, Wu K, Smith-Warner SA, Cao Y, Hu FB, Ogino S, Fuchs CS and Giovannucci EL: Association of dietary inflammatory potential with colorectal cancer risk in men and women. JAMA Oncol. 4:366–373. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tabung FK, Smith-Warner SA, Chavarro JE, Wu K, Fuchs CS, Hu FB, Chan AT, Willett WC and Giovannucci EL: Development and validation of an empirical dietary inflammatory index. J Nutr. 146:1560–1570. 2016. View Article : Google Scholar : PubMed/NCBI | |
Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, et al: Diets that promote colon inflammation associate with risk of colorectal carcinomas that contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 16:1622–1631.e3. 2018. View Article : Google Scholar : PubMed/NCBI |