Open Access

Metabolic reprogramming and its clinical application in thyroid cancer (Review)

  • Authors:
    • Shi-Shuai Wen
    • Ting-Ting Zhang
    • Di-Xin Xue
    • Wei-Li Wu
    • Yu-Long Wang
    • Yu Wang
    • Qing-Hai Ji
    • Yong-Xue Zhu
    • Ning Qu
    • Rong-Liang Shi
  • View Affiliations

  • Published online on: June 18, 2019     https://doi.org/10.3892/ol.2019.10485
  • Pages: 1579-1584
  • Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Warburg found that tumor cells exhibit high‑level glycolysis, even under aerobic condition, which is known as the ‘Warburg effect’. As systemic changes in the entire metabolic network are gradually revealed, it is recognized that metabolic reprogramming has gone far beyond the imagination of Warburg. Metabolic reprogramming involves an active change in cancer cells to adapt to their biological characteristics. Thyroid cancer is a common endocrine malignant tumor whose metabolic characteristics have been studied in recent years. Some drugs targeting tumor metabolism are under clinical trial. This article reviews the metabolic changes and mechanisms in thyroid cancer, aiming to find metabolic‑related molecules that could be potential markers to predict prognosis and metabolic pathways, or could serve as therapeutic targets. Our review indicates that knowledge in metabolic alteration has potential contributions in the diagnosis, treatment and prognostic evaluation of thyroid cancer, but further studies are needed for verification as well.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wen S, Zhang T, Xue D, Wu W, Wang Y, Wang Y, Ji Q, Zhu Y, Qu N, Shi R, Shi R, et al: Metabolic reprogramming and its clinical application in thyroid cancer (Review). Oncol Lett 18: 1579-1584, 2019.
APA
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y. ... Shi, R. (2019). Metabolic reprogramming and its clinical application in thyroid cancer (Review). Oncology Letters, 18, 1579-1584. https://doi.org/10.3892/ol.2019.10485
MLA
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., Shi, R."Metabolic reprogramming and its clinical application in thyroid cancer (Review)". Oncology Letters 18.2 (2019): 1579-1584.
Chicago
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., Shi, R."Metabolic reprogramming and its clinical application in thyroid cancer (Review)". Oncology Letters 18, no. 2 (2019): 1579-1584. https://doi.org/10.3892/ol.2019.10485