Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer

Jiang,Peng; Han,Xiaoting; Zheng,Yingnan; Sui,Jianchao; Bi,Weiping

doi:10.3892/ol.2019.10524

Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer

Authors:
- Peng Jiang
- Xiaoting Han
- Yingnan Zheng
- Jianchao Sui
- Weiping Bi
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Affiliations: Department of Gastroenterology, The Central Hospital of Weihai, Weihai, Shandong 264400, P.R. China, Department of General Surgery, The Central Hospital of Weihai, Weihai, Shandong 264400, P.R. China, Department of Gastroenterology, The Central Hospital of Rizhao, Shandong 276800, P.R. China
Published online on: June 24, 2019 https://doi.org/10.3892/ol.2019.10524
Pages: 2109-2117

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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer‑associated mortality worldwide. The prognosis of patients with CRC at an advanced stage is poor. Biomarkers currently used in clinical practice, including carcinoembryonic antigen (CEA) and cancer antigen (CA) 19‑9, lack sufficient sensitivity and specificity for early diagnosis and prediction, therefore there remains a requirement to improve the prognosis of patients with CRC. Long non‑coding RNAs (lncRNAs) have been revealed to serve fundamental roles in various pathophysiological processes, including cancer initiation and progression. The present study investigated the expression and clinical significance of the lncRNA nuclear factor‑κB interacting long non‑coding RNA (NKILA) in CRC. It was identified that NKILA was downregulated in six CRC cell lines and tissues (n=173). Low NKILA expression was significantly associated with a poor differentiation grade, larger tumor size and advanced Tumor‑Node‑Metastases stages. Further statistical analyses revealed that low NKILA expression predicted poor overall survival (OS) rate and progression‑free survival (PFS) rate. In addition, low NKILA expression was determined as an independent risk factor for poor OS and PFS. Furthermore, NKILA exhibited a relatively high sensitivity and specificity compared with CEA and CA19‑9 in the early diagnosis of CRC. The serum level of NKILA was positively correlated with the level in tissues. In addition, a decreased NKILA level in serum was revealed to be partially restored post‑operatively. In conclusion, low NKILA expression has been demonstrated to accelerate CRC progression and NKILA may be a potential novel biomarker in early diagnosis and prognosis of patients with CRC.

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