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Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer

  • Authors:
    • Kehong Zheng
    • Qianqiong Yang
    • Lang Xie
    • Zhenghua Qiu
    • Yongsheng Huang
    • Yongwei Lin
    • Lingjing Tu
    • Chunhui Cui

  • View Affiliations

  • Published online on: August 5, 2019     https://doi.org/10.3892/ol.2019.10710
  • Pages: 3857-3862
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Abstract

Tumor metastasis and anticancer drug resistance are the major causes of mortality in patients with colorectal cancer (CRC). Due to the limitations of conventional biomarkers, it is urgent to identify novel and valid biomarkers to predict the progression and prognosis of CRC. Reverse transcription‑quantitative polymerase chain reaction and western blotting were used to detect MAGT1 expression in CRC clinical samples or cell lines. Bioinformatics analysis was used to investigate the association between MAGT1 alteration and clinicopathological features of patients with CRC. The present study revealed that the transcription levels of magnesium transporter 1 (MAGT1) were significantly increased in CRC tissues compared with matched adjacent normal tissues. Overexpression of MAGT1 was associated with advanced tumor stage, N and M classification. In addition, for patients who underwent chemotherapy, patients in the MAGT1‑low expression group exhibited a longer overall survival (OS) time than patients in the high‑expression group. Patients with CRC treated with chemotherapy had a longer OS time than those treated without chemotherapy in the MAGT1‑low expression group but not in the MAGT1‑high expression group. Furthermore, MAGT1 was a valid but not an independent prognostic factor for CRC. Therefore, the present study highlighted that MAGT1 may serve as a valid biomarker for predicting the development, progression and poor prognosis of CRC.
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October-2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Zheng K, Yang Q, Xie L, Qiu Z, Huang Y, Lin Y, Tu L and Cui C: Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer. Oncol Lett 18: 3857-3862, 2019.
APA
Zheng, K., Yang, Q., Xie, L., Qiu, Z., Huang, Y., Lin, Y. ... Cui, C. (2019). Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer. Oncology Letters, 18, 3857-3862. https://doi.org/10.3892/ol.2019.10710
MLA
Zheng, K., Yang, Q., Xie, L., Qiu, Z., Huang, Y., Lin, Y., Tu, L., Cui, C."Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer". Oncology Letters 18.4 (2019): 3857-3862.
Chicago
Zheng, K., Yang, Q., Xie, L., Qiu, Z., Huang, Y., Lin, Y., Tu, L., Cui, C."Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer". Oncology Letters 18, no. 4 (2019): 3857-3862. https://doi.org/10.3892/ol.2019.10710