Open Access

Role of circular RNA in hematological malignancies (Review)

  • Authors:
    • Mei Mei
    • Yingjun Wang
    • Zhaoming Li
    • Mingzhi Zhang
  • View Affiliations

  • Published online on: September 10, 2019     https://doi.org/10.3892/ol.2019.10836
  • Pages: 4385-4392
  • Copyright: © Mei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Compared with linear RNA, circular RNAs (circRNAs) form a covalently closed circular continuous loop and are highly conserved, stable and tissue‑specific. In recent years, circRNAs received considerable attention in the diagnosis, classification, treatment and prognosis of hematological tumors. circRNAs function as microRNA sponges and competitive endogenous RNAs that play an essential role in the translation, regulation and interaction of proteins. The present review discussed the fundamental properties and functions of circRNAs and the latest advancements in the context of circRNAs in the clinical research of hematological malignancies, namely acute and chronic myeloid leukemia, and chronic lymphocytic leukemia. circRNAs show potential in the diagnosis and prognosis of various diseases and can be used as therapeutic targets and biomarkers for disease.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Mei M, Wang Y, Li Z and Zhang M: Role of circular RNA in hematological malignancies (Review). Oncol Lett 18: 4385-4392, 2019
APA
Mei, M., Wang, Y., Li, Z., & Zhang, M. (2019). Role of circular RNA in hematological malignancies (Review). Oncology Letters, 18, 4385-4392. https://doi.org/10.3892/ol.2019.10836
MLA
Mei, M., Wang, Y., Li, Z., Zhang, M."Role of circular RNA in hematological malignancies (Review)". Oncology Letters 18.5 (2019): 4385-4392.
Chicago
Mei, M., Wang, Y., Li, Z., Zhang, M."Role of circular RNA in hematological malignancies (Review)". Oncology Letters 18, no. 5 (2019): 4385-4392. https://doi.org/10.3892/ol.2019.10836