Open Access

Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells (Review)

  • Authors:
    • Hui Zhou
    • Lina Sun
    • Fusheng Wan
  • View Affiliations

  • Published online on: September 10, 2019     https://doi.org/10.3892/ol.2019.10848
  • Pages: 4393-4402
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) are RNA sequences >200 nucleotides in length that have no protein‑coding capacity. lncRNAs serve key roles in multiple biological processes, such as tumorigenesis and tumor progression. Taurine upregulated 1 (TUG1) is a novel lncRNA that has been associated with human cancer. TUG1 has attracted increasing attention in recent years and has been documented to be abnormally expressed in different types of cancer. Numerous studies indicate that TUG1 may be significantly associated with tumor development and cell metabolism by regulating cell proliferation, invasion, metastasis, apoptosis, differentiation and drug resistance. TUG1 exerts its function via recruiting specific RNA‑binding proteins, promoting target gene expression, influencing tumor angiogenesis and by functioning as a competing endogenous RNA (ceRNA). An increasing number of studies have demonstrated that ceRNAs serve a role in cancer development. TUG1 is considered to be a biomarker or a novel therapeutic target for the diagnosis and prognosis of different cancer types. The present review focuses on recent developments in the major underlying molecular mechanisms of TUG1 in cancer, including its role in cell proliferation, apoptosis, migration, invasion and drug resistance. Also discussed in the present review is the current knowledge regarding the regulation of TUG1.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou H, Sun L and Wan F: Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells (Review). Oncol Lett 18: 4393-4402, 2019.
APA
Zhou, H., Sun, L., & Wan, F. (2019). Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells (Review). Oncology Letters, 18, 4393-4402. https://doi.org/10.3892/ol.2019.10848
MLA
Zhou, H., Sun, L., Wan, F."Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells (Review)". Oncology Letters 18.5 (2019): 4393-4402.
Chicago
Zhou, H., Sun, L., Wan, F."Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells (Review)". Oncology Letters 18, no. 5 (2019): 4393-4402. https://doi.org/10.3892/ol.2019.10848