1
|
Fletcher GC, Patel S, Tyson K, Adam PJ,
Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL and
Terrett JA: hAG-2 and hAG-3, human homologues of genes involved in
differentiation, are associated with oestrogen receptor-positive
breast tumours and interact with metastasis gene C4.4a and
dystroglycan. Br J Cancer. 88:579–585. 2003. View Article : Google Scholar : PubMed/NCBI
|
2
|
Higa A, Mulot A, Delom F, Bouchecareilh M,
Nguyên DT, Boismenu D, Wise MJ and Chevet E: Role of pro-oncogenic
protein disulfide isomerase (PDI) family member anterior gradient 2
(AGR2) in the control of endoplasmic reticulum homeostasis. J Biol
Chem. 286:44855–44868. 2011. View Article : Google Scholar : PubMed/NCBI
|
3
|
Brychtova V, Mohtar A, Vojtesek B and Hupp
TR: Mechanisms of anterior gradient-2 regulation and function in
cancer. Semin Cancer Biol. 33:16–24. 2015. View Article : Google Scholar : PubMed/NCBI
|
4
|
Park SW, Zhen G, Verhaeghe C, Nakagami Y,
Nguyenvu LT, Barczak AJ, Killeen N and Erle DJ: The protein
disulfide isomerase AGR2 is essential for production of intestinal
mucus. Proc Natl Acad Sci USA. 106:6950–6955. 2009. View Article : Google Scholar : PubMed/NCBI
|
5
|
Schroeder BW, Verhaeghe C, Park SW,
Nguyenvu LT, Huang X, Zhen G and Erle DJ: AGR2 is induced in asthma
and promotes allergen-induced mucin overproduction. Am J Respir
Cell Mol Biol. 47:178–185. 2012. View Article : Google Scholar : PubMed/NCBI
|
6
|
Norris AM, Gore A, Balboni A, Young A,
Longnecker DS and Korc M: AGR2 is a SMAD4-suppressible gene that
modulates MUC1 levels and promotes the initiation and progression
of pancreatic intraepithelial neoplasia. Oncogene. 32:3867–3876.
2013. View Article : Google Scholar : PubMed/NCBI
|
7
|
Bonser LR, Schroeder BW, Ostrin LA,
Baumlin N, Olson JL, Salathe M and Erle DJ: The endoplasmic
reticulum resident protein AGR3. Required for regulation of ciliary
beat frequency in the airway. Am J Respir Cell Mol Biol.
53:536–543. 2015. View Article : Google Scholar : PubMed/NCBI
|
8
|
Gray TA, MacLaine NJ, Michie CO,
Bouchalova P, Murray E, Howie J, Hrstka R, Maslon MM, Nenutil R,
Vojtesek B, et al: Anterior Gradient-3: A novel biomarker for
ovarian cancer that mediates cisplatin resistance in xenograft
models. J Immunol Methods. 378:20–32. 2012. View Article : Google Scholar : PubMed/NCBI
|
9
|
Brychtova V, Zampachova V, Hrstka R,
Fabian P, Novak J, Hermanova M and Vojtesek B: Differential
expression of anterior gradient protein 3 in intrahepatic
cholangiocarcinoma and hepatocellular carcinoma. Exp Mol Pathol.
96:375–381. 2014. View Article : Google Scholar : PubMed/NCBI
|
10
|
Vivekanandan P, Micchelli ST and Torbenson
M: Anterior gradient-2 is overexpressed by fibrolamellar
carcinomas. Hum Pathol. 40:293–299. 2009. View Article : Google Scholar : PubMed/NCBI
|
11
|
Obacz J, Takacova M, Brychtova V, Dobes P,
Pastorekova S, Vojtesek B and Hrstka R: The role of AGR2 and AGR3
in cancer: Similar but not identical. Eur J Cell Biol. 94:139–147.
2015. View Article : Google Scholar : PubMed/NCBI
|
12
|
Brychtova V, Vojtesek B and Hrstka R:
Anterior gradient 2: A novel player in tumor cell biology. Cancer
Lett. 304:1–7. 2011. View Article : Google Scholar : PubMed/NCBI
|
13
|
Chevet E, Fessart D, Delom F, Mulot A,
Vojtesek B, Hrstka R, Murray E, Gray T and Hupp T: Emerging roles
for the pro-oncogenic anterior gradient-2 in cancer development.
Oncogene. 32:2499–2509. 2013. View Article : Google Scholar : PubMed/NCBI
|
14
|
Salmans ML, Zhao F and Andersen B: The
estrogen-regulated anterior gradient 2 (AGR2) protein in breast
cancer: A potential drug target and biomarker. Breast Cancer Res.
15:2042013. View
Article : Google Scholar : PubMed/NCBI
|
15
|
Kamal A, Valentijn A, Barraclough R,
Rudland P, Rahmatalla N, Martin-Hirsch P, Stringfellow H, Decruze
SB and Hapangama DK: High AGR2 protein is a feature of low grade
endometrial cancer cells. Oncotarget. 9:31459–31472. 2018.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Bergstrom JH, Berg KA, Rodriguez-Pineiro
AM, Stecher B, Johansson ME and Hansson GC: AGR2, an endoplasmic
reticulum protein, is secreted into the gastrointestinal mucus.
PLoS One. 9:e1041862014. View Article : Google Scholar : PubMed/NCBI
|
17
|
Edgell TA, Barraclough DL, Rajic A, Dhulia
J, Lewis KJ, Armes JE, Barraclough R, Rudland PS, Rice GE and
Autelitano DJ: Increased plasma concentrations of anterior gradient
2 protein are positively associated with ovarian cancer. Clin Sci
(Lond). 118:717–725. 2010. View Article : Google Scholar : PubMed/NCBI
|
18
|
Kani K, Malihi PD, Jiang Y, Wang H, Wang
Y, Ruderman DL, Agus DB, Mallick P and Gross ME: Anterior gradient
2 (AGR2): Blood-based biomarker elevated in metastatic prostate
cancer associated with the neuroendocrine phenotype. Prostate.
73:306–315. 2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
Garczyk S, von Stillfried S, Antonopoulos
W, Hartmann A, Schrauder MG, Fasching PA, Anzeneder T, Tannapfel A,
Ergönenc Y, Knüchel R, et al: AGR3 in breast cancer: Prognostic
impact and suitable serum-based biomarker for early cancer
detection. PLoS One. 10:e01221062015. View Article : Google Scholar : PubMed/NCBI
|
20
|
Tian S, Hu J, Tao K, Wang J, Chu Y, Li J,
Liu Z, Ding X, Xu L, Li Q, et al: Secreted AGR2 promotes invasion
of colorectal cancer cells via Wnt11-mediated non-canonical Wnt
signaling. Exp Cell Res. 364:198–207. 2018. View Article : Google Scholar : PubMed/NCBI
|
21
|
Tsuji T, Satoyoshi R, Aiba N, Kubo T,
Yanagihara K, Maeda D, Goto A, Ishikawa K, Yashiro M and Tanaka M:
Agr2 mediates paracrine effects on stromal fibroblasts that promote
invasion by gastric signet-ring carcinoma cells. Cancer Res.
75:356–366. 2015. View Article : Google Scholar : PubMed/NCBI
|
22
|
Arumugam T, Deng D, Bover L, Wang H,
Logsdon CD and Ramachandran V: New blocking antibodies against
novel AGR2-C4.4A pathway reduce growth and metastasis of pancreatic
tumors and increase survival in mice. Mol Cancer Ther. 14:941–951.
2015. View Article : Google Scholar : PubMed/NCBI
|
23
|
Fessart D, Domblides C, Avril T, Eriksson
LA, Begueret H, Pineau R, Malrieux C, Dugot-Senant N, Lucchesi C,
Chevet E and Delom F: Secretion of protein disulphide isomerase
AGR2 confers tumorigenic properties. Elife. 5(pii): e138872016.
View Article : Google Scholar : PubMed/NCBI
|
24
|
Adam PJ, Boyd R, Tyson KL, Fletcher GC,
Stamps A, Hudson L, Poyser HR, Redpath N, Griffiths M, Steers G, et
al: Comprehensive proteomic analysis of breast cancer cell
membranes reveals unique proteins with potential roles in clinical
cancer. J Biol Chem. 278:6482–6489. 2003. View Article : Google Scholar : PubMed/NCBI
|
25
|
Obacz J, Brychtova V, Podhorec J, Fabian
P, Dobes P, Vojtesek B and Hrstka R: Anterior gradient protein 3 is
associated with less aggressive tumors and better outcome of breast
cancer patients. Onco Targets Ther. 8:1523–1532. 2015.PubMed/NCBI
|
26
|
Bu H, Schweiger MR, Manke T, Wunderlich A,
Timmermann B, Kerick M, Pasqualini L, Shehu E, Fuchsberger C, Cato
AC and Klocker H: Anterior gradient 2 and 3-two prototype
androgen-responsive genes transcriptionally upregulated by
androgens and by oestrogens in prostate cancer cells. FEBS J.
280:1249–1266. 2013. View Article : Google Scholar : PubMed/NCBI
|
27
|
King ER, Tung CS, Tsang YT, Zu Z, Lok GT,
Deavers MT, Malpica A, Wolf JK, Lu KH, Birrer MJ, et al: The
anterior gradient homolog 3 (AGR3) gene is associated with
differentiation and survival in ovarian cancer. Am J Surg Pathol.
35:904–912. 2011. View Article : Google Scholar : PubMed/NCBI
|
28
|
Trcka F, Durech M, Man P, Hernychova L,
Muller P and Vojtesek B: The assembly and intermolecular properties
of the Hsp70-Tomm34-Hsp90 molecular chaperone complex. J Biol Chem.
289:9887–9901. 2014. View Article : Google Scholar : PubMed/NCBI
|
29
|
Raetz CR, Ulevitch RJ, Wright SD, Sibley
CH, Ding A and Nathan CF: Gram-negative endotoxin: An extraordinary
lipid with profound effects on eukaryotic signal transduction.
FASEB J. 5:2652–2660. 1991. View Article : Google Scholar : PubMed/NCBI
|
30
|
Fessart D, Simaan M and Laporte SA: c-Src
regulates clathrin adapter protein 2 interaction with beta-arrestin
and the angiotensin II type 1 receptor during clathrin-mediated
internalization. Mol Endocrinol. 19:491–503. 2005. View Article : Google Scholar : PubMed/NCBI
|
31
|
Geback T, Schulz MM, Koumoutsakos P and
Detmar M: TScratch: A novel and simple software tool for automated
analysis of monolayer wound healing assays. Biotechniques.
46:265–274. 2009. View Article : Google Scholar : PubMed/NCBI
|
32
|
Zhang S and Yu D: Targeting Src family
kinases in anti-cancer therapies: Turning promise into triumph.
Trends Pharmacol Sci. 33:122–128. 2012. View Article : Google Scholar : PubMed/NCBI
|
33
|
Vanderlaag KE, Hudak S, Bald L,
Fayadat-Dilman L, Sathe M, Grein J and Janatpour MJ: Anterior
gradient-2 plays a critical role in breast cancer cell growth and
survival by modulating cyclin D1, estrogen receptor-alpha and
survivin. Breast Cancer Res. 12:R322010. View Article : Google Scholar : PubMed/NCBI
|
34
|
Chen Y, Long H, Wu Z, Jiang X and Ma L:
EGF transregulates opioid receptors through EGFR-mediated GRK2
phosphorylation and activation. Mol Biol Cell. 19:2973–2983. 2008.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Hrstka R, Nenutil R, Fourtouna A, Maslon
MM, Naughton C, Langdon S, Murray E, Larionov A, Petrakova K,
Muller P, et al: The pro-metastatic protein anterior gradient-2
predicts poor prognosis in tamoxifen-treated breast cancers.
Oncogene. 29:4838–4847. 2010. View Article : Google Scholar : PubMed/NCBI
|
36
|
Fritzsche FR, Dahl E, Pahl S, Burkhardt M,
Luo J, Mayordomo E, Gansukh T, Dankof A, Knuechel R, Denkert C, et
al: Prognostic relevance of AGR2 expression in breast cancer. Clin
Cancer Res. 12:1728–1734. 2006. View Article : Google Scholar : PubMed/NCBI
|
37
|
Bu H, Bormann S, Schafer G, Horninger W,
Massoner P, Neeb A, Lakshmanan VK, Maddalo D, Nestl A, Sültmann H,
et al: The anterior gradient 2 (AGR2) gene is overexpressed in
prostate cancer and may be useful as a urine sediment marker for
prostate cancer detection. Prostate. 71:575–587. 2011. View Article : Google Scholar : PubMed/NCBI
|
38
|
Ramachandran V, Arumugam T, Wang H and
Logsdon CD: Anterior gradient 2 is expressed and secreted during
the development of pancreatic cancer and promotes cancer cell
survival. Cancer Res. 68:7811–7818. 2008. View Article : Google Scholar : PubMed/NCBI
|
39
|
de Souza WF, Fortunato-Miranda N, Robbs
BK, de Araujo WM, de-Freitas-Junior JC, Bastos LG, Viola JP and
Morgado-Díaz JA: Claudin-3 overexpression increases the malignant
potential of colorectal cancer cells: Roles of ERK1/2 and PI3K-Akt
as modulators of EGFR signaling. PLoS One. 8:e749942013. View Article : Google Scholar : PubMed/NCBI
|
40
|
Shao H, Gu Y, Ding J, Lu P, Ruan T and Lu
W: HEPACAM inhibited the growth and migration of cancer cells in
the progression of non-small cell lung cancer. Tumour Biol.
37:2621–2627. 2016. View Article : Google Scholar : PubMed/NCBI
|
41
|
Maurel M, Obacz J, Avril T, Ding YP,
Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, et
al: Control of anterior GRadient 2 (AGR2) dimerization links
endoplasmic reticulum proteostasis to inflammation. EMBO Mol Med.
11(pii): e101202019. View Article : Google Scholar : PubMed/NCBI
|
42
|
Aberger F, Weidinger G, Grunz H and
Richter K: Anterior specification of embryonic ectoderm: The role
of the Xenopus cement gland-specific gene XAG-2. Mech Dev.
72:115–130. 1998. View Article : Google Scholar : PubMed/NCBI
|