Open Access

Combination of checkpoint inhibitors with radiotherapy in esophageal squamous cell carcinoma treatment: A novel strategy (Review)

  • Authors:
    • Xiu‑Yong Liao
    • Chao‑Yuan Liu
    • Jian‑Feng He
    • Li‑Shu Wang
    • Tao Zhang
  • View Affiliations

  • Published online on: September 19, 2019     https://doi.org/10.3892/ol.2019.10893
  • Pages: 5011-5021
  • Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite the rapid development of numerous types of treatment, including radiotherapy (RT) as the main strategy, esophageal squamous cell carcinoma (ESCC) has a poor prognosis. Recent studies demonstrated that immunotherapy can improve the survival of patients with locally advanced and metastatic ESCC. Furthermore, previous studies reported that the expression of programmed death‑ligand 1 is significantly associated with esophageal cancer prognosis. At present, several ongoing clinical trials have extended the use of immunotherapy from palliative and salvage treatments to neoadjuvant treatment with concurrent chemoradiation. The first‑ or second‑line treatments were used to explore antitumor efficacy with reduced adverse events. The combination of RT and immunotherapy can exert a local therapeutic effect and improve the function of the immune system, enhancing antitumor efficacy. This review investigated the role of immunotherapy and radiotherapy in ESCC and described the potential efficacy of combining immunotherapy with radiotherapy in ESCC.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liao XY, Liu CY, He JF, Wang LS and Zhang T: Combination of checkpoint inhibitors with radiotherapy in esophageal squamous cell carcinoma treatment: A novel strategy (Review). Oncol Lett 18: 5011-5021, 2019.
APA
Liao, X., Liu, C., He, J., Wang, L., & Zhang, T. (2019). Combination of checkpoint inhibitors with radiotherapy in esophageal squamous cell carcinoma treatment: A novel strategy (Review). Oncology Letters, 18, 5011-5021. https://doi.org/10.3892/ol.2019.10893
MLA
Liao, X., Liu, C., He, J., Wang, L., Zhang, T."Combination of checkpoint inhibitors with radiotherapy in esophageal squamous cell carcinoma treatment: A novel strategy (Review)". Oncology Letters 18.5 (2019): 5011-5021.
Chicago
Liao, X., Liu, C., He, J., Wang, L., Zhang, T."Combination of checkpoint inhibitors with radiotherapy in esophageal squamous cell carcinoma treatment: A novel strategy (Review)". Oncology Letters 18, no. 5 (2019): 5011-5021. https://doi.org/10.3892/ol.2019.10893