Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer (Review)
- Authors:
- Zhongjie Yu
- Qi Li
- Yi An
- Xiatian Chen
- Ziqian Liu
- Zhe Li
- Jinning Gao
- Lynn Htet Htet Aung
- Peifeng Li
-
Affiliations: Center for Molecular Genetics, Institute for Translational Medicine, Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong 266000, P.R. China - Published online on: October 11, 2019 https://doi.org/10.3892/ol.2019.10981
- Pages: 5691-5698
-
Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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 |
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|
Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Adhihetty PJ, Ljubicic V and Hood DA: Effect of chronic contractile activity on SS and IMF mitochondrial apoptotic susceptibility in skeletal muscle. Am J Physiol Endocrinol Metab. 292:E748–E755. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Crews L, Patrick C, Adame A, Rockenstein E and Masliah E: Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death Dis. 2:e1202011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang K, Long B, Zhou LY, Liu F, Zhou QY, Liu CY, Fan YY and Li PF: CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation. Nat Commun. 5:35962014. View Article : Google Scholar : PubMed/NCBI | |
|
Qiao G, Li Z, Minto AW, Shia J, Yang L, Bao L, Tschopp J, Gao JX, Wang J, Quigg RJ and Zhang J: Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain. Cell Death Differ. 17:522–533. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC and Perucho M: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science. 257:967–969. 1997. View Article : Google Scholar | |
|
Mitra A, Basak T, Datta K, Naskar S, Sengupta S and Sarkar S: Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. Cell Death Dis. 4:e5822013. View Article : Google Scholar : PubMed/NCBI | |
|
Favaloro B, Allocati N, Graziano V, Di Ilio C and De Laurenzi V: Role of apoptosis in disease. Aging (Albany NY). 4:330–349. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Medina-Ramirez CM, Goswami S, Smirnova T, Bamira D, Benson B, Ferrick N, Segall J, Pollard JW and Kitsis RN: Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance. Cancer Res. 71:7705–7715. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Koseki T, Inohara N, Chen S and Núñez G: ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci USA. 95:5156–5160. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Wang JX, Li Q and Li PF: Apoptosis repressor with caspase recruitment domain contributes to chemotherapy resistance by abolishing mitochondrial fission mediated by dynamin-related protein-1. Cancer Res. 69:492–500. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Stoss O, Schwaiger FW, Cooper TA and Stamm S: Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. J Biol Chem. 274:10951–10962. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Jang TH, Kim SH, Jeong JH, Kim S, Kim YG and Park HH: Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis. Sci Rep. 5:98472015. View Article : Google Scholar : PubMed/NCBI | |
|
Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ and Kitsis RN: Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell. 15:901–912. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Gustafsson AB, Tsai JG, Logue SE, Crow MT and Gottlieb RA: Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. J Biol Chem. 279:21233–21238. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH, Shim SM, Lee HJ, Cho C, Kim DH and Jung YK: Calcium binding of ARC mediates regulation of caspase 8 and cell death. Mol Cell Biol. 24:9763–9770. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Foo RS, Nam YJ, Ostreicher MJ, Metzl MD, Whelan RS, Peng CF, Ashton AW, Fu W, Mani K, Chin SF, et al: Regulation of p53 tetramerization and nuclear export by ARC. Proc Natl Acad Sci USA. 104:20826–20831. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Engidawork E, Gulesserian T, Yoo BC, Cairns N and Lubec G: Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. Biochem Biophys Res Commun. 281:84–93. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Quadrilatero J and Bloemberg D: Apoptosis repressor with caspase recruitment domain is dramatically reduced in cardiac, skeletal, and vascular smooth muscle during hypertension. Biochem Biophys Res Commun. 391:1437–1442. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Jewgenow K, Neubauer K, Blottner S, Schön J, Wildt DE and Pukazhenthi BS: Reduced germ cell apoptosis during spermatogenesis in the teratospermic domestic cat. J Androl. 30:460–468. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Sasson R, Rimon E, Dantes A, Cohen T, Shinder V, Land-Bracha A and Amsterdam A: Gonadotrophin-induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic genes, cytoskeletal genes and genes coding for apoptotic signalling and protein kinases. Mol Hum Reprod. 10:299–311. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
McKimpson WM, Weinberger J, Czerski L, Zheng M, Crow MT, Pessin JE, Chua SC Jr and Kitsis RN: The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival. Diabetes. 62:183–193. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Guan M, Fang Q, He Z, Li Y, Qian F, Qian X, Lu L, Zhang X, Liu D, Qi J, et al: Inhibition of ARC decreases the survival of HEI-OC-1 cells after neomycin damage in vitro. Oncotarget. 7:66647–66659. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Chatterjee S, Bish LT, Jayasankar V, Stewart AS, Woo YJ, Crow MT, Gardner TJ and Sweeney HL: Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain. J Thorac Cardiovasc Surg. 125:1461–1469. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, et al: A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 124:2533–2542. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Xi Z, Guo R, Liu S, Yang S, Liu D, Dong S and Guo D: Exogenous ARC down-regulates caspase-3 expression and inhibits apoptosis of broiler chicken cardiomyocytes exposed to hydrogen peroxide. Avian Pathol. 42:32–37. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ekhterae D, Lin Z, Lundberg MS, Crow MT, Brosius FC III and Núñez G: ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circ Res. 85:e70–e77. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
An J, Li P, Li J, Dietz R and Donath S: ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity. J Mol Med (Berl). 87:401–410. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ekhterae D, Platoshyn O, Zhang S, Remillard CV and Yuan JX: Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents. Am J Physiol Cell Physiol. 284:C1405–C1410. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
An J, Harms C, Lättig-Tünnemann G, Sellge G, Mandić AD, Malato Y, Heuser A, Endres M, Trautwein C and Donath S: TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure. Hepatology. 56:715–726. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kung G, Dai P, Deng L and Kitsis RN: A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis. Cell Death Differ. 21:634–644. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Abmayr S, Crawford RW and Chamberlain JS: Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle. Hum Mol Gene. 13:213–221. 2004. View Article : Google Scholar | |
|
Hu L, Han J, Yang X, Wang Y, Pan H and Xu L: Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment. Mol Med Rep. 14:3535–3542. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hunter AL, Zhang J, Chen SC, Si X, Wong B, Ekhterae D, Luo H and Granville DJ: Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation. FEBS Lett. 581:879–884. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Mitchell AS, Smith IC, Gamu D, Donath S, Tupling AR and Quadrilatero J: Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice. Apoptosis. 20:310–326. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, et al: Familial cortical myoclonus with a mutation in NOL3. Ann Neurol. 72:175–183. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Tóth C, Meinrath J, Herpel E, Derix J, Fries J, Buettner R, Schirmacher P and Heikaus S: Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. J Cancer Res Clin Oncol. 142:927–935. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Mercier I, Vuolo M, Jasmin JF, Medina CM, Williams M, Mariadason JM, Qian H, Xue X, Pestell RG, Lisanti MP and Kitsis RN: ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer. Cell Cycle. 7:1640–1647. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Wang JX, He YQ, Feng C, Zhang XJ, Sheng JQ and Li PF: MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. Cell Death Dis. 5:e11972014. View Article : Google Scholar : PubMed/NCBI | |
|
Toth C, Funke S, Nitsche V, Liverts A, Zlachevska V, Gasis M, Wiek C, Hanenberg H, Mahotka C, Schirmacher P and Heikaus S: The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): The crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling. Cell Commun Signal. 15:162017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Q, Li A, Wang H and Wang J: Knockdown of apoptosis repressor with caspase recruitment domain (ARC) increases the sensitivity of human glioma cell line U251MG to VM-26. Int J Clin Exp Pathol. 5:555–561. 2012.PubMed/NCBI | |
|
Gobe GC, Ng KL, Small DM, Vesey DA, Johnson DW, Samaratunga H, Oliver K, Wood S, Barclay JL, Rajandram R, et al: Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways. Biochem Biophys Res Commun. 473:47–53. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Nam YJ, Kung G, Crow MT and Kitsis RN: Induction of the apoptosis inhibitor ARC by Ras in human cancers. J Biol Chem. 285:19235–19245. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Mak PY, Mak DH, Ruvolo V, Jacamo R, Kornblau SM, Kantarjian H, Andreeff M and Carter BZ: Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia. Br J Haematol. 167:376–384. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Carter BZ, Qiu YH, Zhang N, Coombes KR, Mak DH, Thomas DA, Ravandi F, Kantarjian HM, Koller E, Andreeff M and Kornblau SM: Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML. Blood. 117:780–787. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mak PY, Mak DH, Mu H, Shi Y, Ruvolo P, Ruvolo V, Jacamo R, Burks JK, Wei W, Huang X, et al: Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML. Apoptosis. 19:698–707. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wu P, Tang Y, He J, Qi L, Jiang W and Zhao S: ARC is highly expressed in nasopharyngeal carcinoma and confers X-radiation and cisplatin resistance. Oncol Rep. 30:1807–1813. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chen LH, Jiang CC, Watts R, Thorne RF, Kiejda KA, Zhang XD and Hersey P: Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein. Cancer Res. 68:834–842. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P and Zhang XD: Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. Cancer Res. 68:6708–6717. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Carter BZ, Mak PY, Wang X, Tao W, Ruvolo V, Mak D, Mu H, Burks JK and Andreeff M: An ARC-regulated IL1β/Cox-2/PGE2/β-catenin/ARC circuit controls leukemia-microenvironment interactions and confers drug resistance in AML. Cancer Res. 79:1165–1177. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Huang W, Su G, Huang X, Zou A, Wu J, Yang Y, Zhu Y, Liang S, Li D, Ma F and Guo L: Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2. Cell Cycle. 18:69–83. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lu D, Liu J, Jiao J, Long B, Li Q, Tan W and Li P: Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. J Biol Chem. 288:8491–8504. 2003. View Article : Google Scholar | |
|
Kavazis AN, McClung JM, Hood DA and Powers SK: Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli. Am J Physiol Heart Circ Physiol. 294:H928–H935. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Yaniv G, Shilkrut M, Lotan R, Berke G, Larisch S and Binah O: Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes. Cardiovasc Res. 54:611–623. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS, Krishnamurthy B, Miao W, Ashton AW, Lefer DJ and Kitsis RN: The apoptosis inhibitor ARC undergoes ubiquitin- proteasomal-mediated degradation in response to death stimuli: Identification of a degradation-resistant mutant. J Biol Chem. 282:5522–5528. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Neuss M, Monticone R, Lundberg MS, Chesley AT, Fleck E and Crow MT: The apoptotic regulatory protein ARC (apoptosis repressor with caspase recruitment domain) prevents oxidant stress-mediated cell death by preserving mitochondrial function. J Biol Chem. 276:33915–33922. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Foo RS, Chan LK, Kitsis RN and Bennett MR: Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2. J Biol Chem. 282:5529–5535. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Du N, Zhang Q, Li J, Chen X, Liu X, Hu Y, Qin W, Shen N, Xu C, et al: MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy. Cell Death Dis. 5:e14792014. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H, Huang T, Ying L, Han C, Li D, Xu Y, Zhang M, Mou S and Dong Z: MiR-155 is involved in renal ischemia-reperfusion injury via direct targeting of FoxO3a and regulating renal tubular cell pyroptosis. Cell Physiol Biochem. 40:1692–1705. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Li YZ, Lu DY, Tan WQ, Wang JX and Li PF: p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Mol Cell Biol. 28:564–574. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Loan Le TY, Mardini M, Howell VM, Funder JW, Ashton AW and Mihailidou AS: Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction. Hypertension. 59:1164–1169. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Li C, Zhang D, Shi D, Qi M, Feng J, Yuan T, Xu X, Liang D, Xu L, et al: SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. Nat Commun. 5:51772014. View Article : Google Scholar : PubMed/NCBI | |
|
Quadrilatero J and Rush JW: Evidence for a pro-apoptotic phenotype in skeletal muscle of hypertensive rats. Biochem Biophys Res Commun. 368:168–174. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
McMillan EM, Graham DA, Rush JW and Quadrilatero J: Decreased DNA fragmentation and apoptotic signaling in soleus muscle of hypertensive rats following 6 weeks of treadmill training. J Appl Physiol (1985). 113:1048–1057. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Dowds TA and Sabban EL: Endogenous and exogenous ARC in serum withdrawal mediated PC12 cell apoptosis: A new pro-apoptotic role for ARC. Cell Death Differ. 8:640–648. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Li PF, Li J, Müller EC, Otto A, Dietz R and von Harsdorf R: Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC. Mol Cell. 10:247–258. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Danial NN and Korsmeyer SJ: Cell death: Critical control points. Cell. 116:205–219. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Itoh N and Nagata S: A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem. 268:10932–10937. 1993.PubMed/NCBI | |
|
Tait SW and Green DR: Mitochondria and cell death: Outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 11:621–632. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Parrish AB, Freel CD and Kornbluth S: Cellular mechanisms controlling caspase activation and function. Cold Spring Harb Perspect Biol. 5:2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pollack M and Leeuwenburgh C: Apoptosis and aging: Role of the mitochondria. J Gerontol A Biol Sci Med Sci. 56:B475–B482. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Dirks A and Leeuwenburgh C: Apoptosis in skeletal muscle with aging. Am J Physiol Regul Integr Comp Physiol. 282:R519–R527. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Ha HJ and Park HH: Molecular basis for the effect of the L31F mutation on CARD function in ARC. FEBS Lett. 591:2919–2928. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Dirks AJ and Leeuwenburgh C: Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Free Radic Biol Med. 36:27–39. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Wang JX, Zhang XJ, Feng C, Sun T, Wang K, Wang Y, Zhou LY and Li PF: MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity. Cell Death Dis. 6:e16772015. View Article : Google Scholar : PubMed/NCBI | |
|
Li YZ, Liu XH, Zhu XM and Cai LR: ARC contributes to the inhibitory effect of preconditioning on cardiomyocyte apoptosis. Apoptosis. 12:1589–1595. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
An J, Mehrhof F, Harms C, Lättig-Tünnemann G, Lee SL, Endres M, Li M, Sellge G, Mandić AD, Trautwein C and Donath S: ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis. J Hepatol. 58:297–305. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Templin AT, Samarasekera T, Meier DT, Hogan MF, Mellati M, Crow MT, Kitsis RN, Zraika S, Hull RL and Kahn SE: Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced β-cell apoptosis and JNK pathway activation. Diabetes. 66:2636–2645. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, et al: Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation. 113:1203–1212. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Ziegler DS, Wright RD, Kesari S, Lemieux ME, Tran MA, Jain M, Zawel L and Kung AL: Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins. J Clin Invest. 118:3109–3122. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Mercier I, Vuolo M, Madan R, Xue X, Levalley AJ, Ashton AW, Jasmin JF, Czaja MT, Lin EY, Armstrong RC, et al: ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance. Cell Death Differ. 12:682–686. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, et al: Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network. Oncotarget. 7:20054–20067. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Feng C, He Y, Ding W, Sheng J, Arshad M, Zhang X and Li P: Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis. Oncotarget. 6:27700–27713. 2015.PubMed/NCBI | |
|
Damiano JS and Reed JC: CARD proteins as therapeutic targets in cancer. Curr Drug Targets. 5:367–374. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Vaux DL and Strasser A: The molecular biology of apoptosis. Proc Natl Acad Sci USA. 93:2239–2244. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science. 267:1456–1462. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Fidler MM, Bray F and Soerjomataram I: The global cancer burden and human development: A review. Scand J Public Health. 46:27–36. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Gorjánácz M: Nuclear assembly as a target for anti-cancer therapies. Nucleus. 5:47–55. 2014. View Article : Google Scholar : PubMed/NCBI |
