Expression levels and prognostic values of annexins in liver cancer
- Authors:
- Chunbo Zhuang
- Pei Wang
- Ting Sun
- Lei Zheng
- Liang Ming
-
Affiliations: Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China - Published online on: October 30, 2019 https://doi.org/10.3892/ol.2019.11025
- Pages: 6657-6669
-
Copyright: © Zhuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
 |
|
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
El-Serag HB: Hepatocellular carcinoma. N Engl J Med. 365:1118–1127. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Enrich C, Rentero C and Grewal T: Annexin A6 in the liver: From the endocytic compartment to cellular physiology. Biochim Biophys Acta Mol Cell Res. 1864:933–946. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sugimoto MA, Vago JP, Teixeira MM and Sousa LP: Annexin A1 and the resolution of inflammation: Modulation of neutrophil recruitment, apoptosis, and clearance. J Immunol Res. 2016:82392582016. View Article : Google Scholar : PubMed/NCBI | |
|
Rand JH, Wu XX, Quinn AS and Taatjes DJ: Resistance to annexin A5 anticoagulant activity: A thrombogenic mechanism for the antiphospholipid syndrome. Lupus. 17:922–930. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Gerke V, Creutz CE and Moss SE: Annexins: linking Ca2+ signalling to membrane dynamics. Nat Rev Mol Cell Biol. 6:449–461. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Mussunoor S and Murray GI: The role of annexins in tumour development and progression. J Pathol. 216:131–140. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ydy LR, do Espirito Santo GF, de Menezes I, Martins MS, Ignotti E and Damazo AS: Study of the annexin A1 and its associations with carcinoembryonic antigen and mismatch repair proteins in colorectal cancer. J Gastrointest Cancer. 47:61–68. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Biaoxue R, Xiling J, Shuanying Y, Wei Z, Xiguang C, Jinsui W and Min Z: Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients. J Exp Clin Cancer Res. 31:702012. View Article : Google Scholar : PubMed/NCBI | |
|
Gao Y, Chen Y, Xu D, Wang J and Yu G: Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers. BMC Cancer. 14:5202014. View Article : Google Scholar : PubMed/NCBI | |
|
Lin Y, Lin G, Fang W, Zhu H and Chu K: Increased expression of annexin A1 predicts poor prognosis in human hepatocellular carcinoma and enhances cell malignant phenotype. Med Oncol. 31:3272014. View Article : Google Scholar : PubMed/NCBI | |
|
Ibrahim MM, Sun MZ, Huang Y, Jun M, Jin Y, Yue D, Jiasheng W, Zhang J, Qazi AS, Sagoe K and Tang J: Down-regulation of ANXA7 decreases metastatic potential of human hepatocellular carcinoma cells in vitro. Biomed Pharmacother. 67:285–291. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Liu SH, Lin CY, Peng SY, Jeng YM, Pan HW, Lai PL, Liu CL and Hsu HC: Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. Am J Pathol. 160:1831–1837. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Liu YY, Ge C, Tian H, Jiang JY, Zhao FY, Li H, Chen TY, Yao M and Li JJ: The transcription factor Ikaros inhibits cell proliferation by downregulating ANXA4 expression in hepatocellular carcinoma. Am J Cancer Res. 7:1285–1297. 2017.PubMed/NCBI | |
|
Meier EM, Rein-Fischboeck L, Pohl R, Wanninger J, Hoy AJ, Grewal T, Eisinger K, Krautbauer S, Liebisch G, Weiss TS and Buechler C: Annexin A6 protein is downregulated in human hepatocellular carcinoma. Mol Cell Biochem. 418:81–90. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, Shi L, Murota M, Tani J, Kato K, et al: Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol. 33:1157–1163. 2008.PubMed/NCBI | |
|
Pan QZ, Pan K, Weng DS, Zhao JJ, Zhang XF, Wang DD, Lv L, Jiang SS, Zheng HX and Xia JC: Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma. Mol Carcinog. 54:598–607. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cancer Genome Atlas Research Network. Electronic address, . simplewheeler@bcm.edu; Cancer Genome Atlas Research Network: Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell. 169:1327–1341.e23. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Mas VR, Maluf DG, Archer KJ, Yanek K, Kong X, Kulik L, Freise CE, Olthoff KM, Ghobrial RM, McIver P and Fisher R: Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma. Mol Med. 15:85–94. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX and Wang XW: A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res. 70:10202–10212. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wurmbach E, Chen YB, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, et al: Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology. 45:938–947. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Sheikh MH and Solito E: Annexin A1: Uncovering the many talents of an old protein. Int J Mol Sci. 19(pii): E10452018. View Article : Google Scholar : PubMed/NCBI | |
|
D'Acquisto F, Piras G and Rattazzi L: Pro-inflammatory and pathogenic properties of Annexin-A1: The whole is greater than the sum of its parts. Biochem Pharmacol. 85:1213–1218. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, et al: Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. Hepatology. 60:531–544. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Moraes LA, Kar S, Foo SL, Gu T, Toh YQ, Ampomah PB, Sachaphibulkij K, Yap G, Zharkova O, Lukman HM, et al: Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment. Sci Rep. 7:179252017. View Article : Google Scholar : PubMed/NCBI | |
|
de Graauw M, van Miltenburg MH, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Dévédec SE, Smit VT, van der Wal A, et al: Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. Proc Natl Acad Sci USA. 107:6340–6345. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Suo A, Zhang M, Yao Y, Zhang L, Huang C, Nan K and Zhang W: Proteome analysis of the effects of sorafenib on human hepatocellular carcinoma cell line HepG2. Med Oncol. 29:1827–1836. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Hongsrichan N, Rucksaken R, Chamgramol Y, Pinlaor P, Techasen A, Yongvanit P, Khuntikeo N, Pairojkul C and Pinlaor S: Annexin A1: A new immunohistological marker of cholangiocarcinoma. World J Gastroenterol. 19:2456–2465. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Xue LY, Teng LH, Zou SM, Ren LQ, Zheng S, Luo W, Bi R and Lü N: Expression of annexin I in different histological types of carcinomas. Zhonghua Zhong Liu Za Zhi. 29:444–448. 2007.(In Chinese). PubMed/NCBI | |
|
Luo CH, Liu QQ, Zhang PF, Li MY, Chen ZC and Liu YF: Prognostic significance of annexin II expression in non-small cell lung cancer. Clin Transl Oncol. 15:938–946. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Yuan J, Zhang J, Tian R, Ji W, Zhou Y, Yang Y, Song W, Zhang F and Niu R: Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells. Oncotarget. 6:30975–30992. 2015.PubMed/NCBI | |
|
Han Y, Ye J, Dong Y, Xu Z and Du Q: Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E-cadherin. Exp Ther Med. 10:549–554. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Huang YK, Liu H, Wang XZ and Zhu S: Annexin A2 and CD105 expression in pancreatic ductal adenocarcinoma is associated with tumor recurrence and prognosis. Asian Pac J Cancer Prev. 15:9921–9926. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Xiu D, Liu L, Qiao F, Yang H, Cui L and Liu G: Annexin A2 coordinates STAT3 to regulate the invasion and migration of colorectal cancer cells in vitro. Gastroenterol Res Pract. 2016:35214532016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Yao M, Wu W, Qiu L, Sai W, Yang J, Zheng W, Huang J and Yao D: Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma. Tumour Biol. 36:9373–9383. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kling T, Ferrarese R, Ó hAilín D, Johansson P, Heiland DH, Dai F, Vasilikos I, Weyerbrock A, Jörnsten R, Carro MS and Nelander S: Integrative modeling reveals annexin A2-mediated epigenetic control of mesenchymal glioblastoma. EBioMedicine. 12:72–85. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Luo S, Xie C, Wu P, He J, Tang Y, Xu J and Zhao S: Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer. Exp Ther Med. 14:6113–6118. 2017.PubMed/NCBI | |
|
Liu Y, Myrvang HK and Dekker LV: Annexin A2 complexes with S100 proteins: Structure, function and pharmacological manipulation. Br J Pharmacol. 172:1664–1676. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang CY, Chen CL, Tseng YL, Fang YT, Lin YS, Su WC, Chen CC, Chang KC, Wang YC and Lin CF: Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms. J Biol Chem. 287:32512–32524. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jung H, Kim JS, Kim WK, Oh KJ, Kim JM, Lee HJ, Han BS, Kim DS, Seo YS, Lee SC, et al: Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: Implications for gemcitabine resistance in pancreatic cancer. Cell Death Dis. 6:e16062015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HJ, Yao DF, Yao M, Huang H, Wu W, Yan MJ, Yan XD and Chen J: Expression characteristics and diagnostic value of annexin A2 in hepatocellular carcinoma. World J Gastroenterol. 18:5897–5904. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang W, Zhao P, Xu XL, Cai L, Song ZS, Cao DY, Tao KS, Zhou WP, Chen ZN and Dou KF: Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS One. 8:e672682013. View Article : Google Scholar : PubMed/NCBI | |
|
El-Abd N, Fawzy A, Elbaz T and Hamdy S: Evaluation of annexin A2 and as potential biomarkers for hepatocellular carcinoma. Tumour Biol. 37:211–216. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Du R, Liu B, Zhou L, Wang D, He X, Xu X, Zhang L, Niu C and Liu S: Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Cell Death Dis. 9:1262018. View Article : Google Scholar : PubMed/NCBI | |
|
Wang K and Li J: Overexpression of ANXA3 is an independent prognostic indicator in gastric cancer and its depletion suppresses cell proliferation and tumor growth. Oncotarget. 7:86972–86984. 2016.PubMed/NCBI | |
|
Köllermann J, Schlomm T, Bang H, Schwall GP, von Eichel-Streiber C, Simon R, Schostak M, Huland H, Berg W, Sauter G, et al: Expression and prognostic relevance of annexin A3 in prostate cancer. Eur Urol. 54:1314–1323. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Pan QZ, Pan K, Wang QJ, Weng DS, Zhao JJ, Zheng HX, Zhang XF, Jiang SS, Lv L, Tang Y, et al: Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells. Stem Cells. 33:354–366. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Tong M, Fung TM, Luk ST, Ng KY, Lee TK, Lin CH, Yam JW, Chan KW, Ng F, Zheng BJ, et al: ANXA3/JNK signaling promotes self-renewal and tumor growth, and its blockade provides a therapeutic target for hepatocellular carcinoma. Stem Cell Reports. 5:45–59. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ma XL, Jiang M, Zhao Y, Wang BL, Shen MN, Zhou Y, Zhang CY, Sun YF, Chen JW, Hu B, et al: Application of serum annexin A3 in diagnosis, outcome prediction and therapeutic response evaluation for patients with hepatocellular carcinoma. Ann Surg Oncol. 25:1686–1694. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Dreier R, Schmid KW, Gerke V and Riehemann K: Differential expression of annexins I, II and IV in human tissues: An immunohistochemical study. Histochem Cell Biol. 110:137–148. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Gaudio E, Paduano F, Ngankeu A, Ortuso F, Lovat F, Pinton S, D'Agostino S, Zanesi N, Aqeilan RI, Campiglia P, et al: A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells. Oncotarget. 7:29927–29936. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Duncan R, Carpenter B, Main LC, Telfer C and Murray GI: Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer. 98:426–433. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Choi CH, Chung JY, Chung EJ, Sears JD, Lee JW, Bae DS and Hewitt SM: Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer. BMC Cancer. 16:4482016. View Article : Google Scholar : PubMed/NCBI | |
|
Yao HS, Sun C, Li XX, Wang Y, Jin KZ, Zhang XP and Hu ZQ: Annexin A4-nuclear factor-kappaB feedback circuit regulates cell malignant behavior and tumor growth in gallbladder cancer. Sci Rep. 6:310562016. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Chen L, Cai Z, Liang D, Zhao B, Zeng Y, Liu X and Liu J: Overexpression of annexin A4 indicates poor prognosis and promotes tumor metastasis of hepatocellular carcinoma. Tumour Biol. 37:9343–9355. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Peng B, Guo C, Guan H, Liu S and Sun MZ: Annexin A5 as a potential marker in tumors. Clin Chim Acta. 427:42–48. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Guo WX, Man XB, Yuan HX, Shi J, Xue J, Wu MC and Cheng SQ: Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma. Zhonghua Yi Xue Za Zhi. 87:2094–2097. 2007.(In Chinese). PubMed/NCBI | |
|
Sun X, Liu S, Wang J, Wei B, Guo C, Chen C and Sun MZ: Annexin A5 regulates hepatocarcinoma malignancy via CRKI/II-DOCK180-RAC1 integrin and MEK-ERK pathways. Cell Death Dis. 9:6372018. View Article : Google Scholar : PubMed/NCBI | |
|
Srivastava M, Torosyan Y, Raffeld M, Eidelman O, Pollard HB and Bubendorf L: ANXA7 expression represents hormone-relevant tumor suppression in different cancers. Int J Cancer. 121:2628–2636. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Du Y, Meng J, Huang Y, Wu J, Wang B, Ibrahim MM and Tang J: Guanine nucleotide-binding protein subunit beta-2-like 1, a new Annexin A7 interacting protein. Biochem Biophys Res Commun. 445:58–63. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Song L, Mao J, Zhang J, Ibrahim MM, Li LH and Tang JW: Annexin A7 and its binding protein galectin-3 influence mouse hepatocellular carcinoma cell line in vitro. Biomed Pharmacother. 68:377–384. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Huang Y, Wang Q, Du Y, Bai L, Jin F, Zhang J, Fan S, Wang H, Song L, Gao Y, et al: Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line. Biomed Pharmacother. 68:819–824. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang XY, Gao F, Sun YR, Bai LL, Ibrahim MM, Wang B and Tang JW: In vivo and in vitro effect of hepatocarcinoma lymph node metastasis by upregulation of Annexin A7 and relevant mechanisms. Tumour Biol. 37:911–924. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Morgan RO, Jenkins NA, Gilbert DJ, Copeland NG, Balsara BR, Testa JR and Fernandez MP: Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution. Genomics. 60:40–49. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Kim J, Kim MA, Jee CD, Jung EJ and Kim WH: Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma. Int J Cancer. 125:1842–1850. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
van der Heijden AG, Mengual L, Lozano JJ, Ingelmo-Torres M, Ribal MJ, Fernández PL, Oosterwijk E, Schalken JA, Alcaraz A and Witjes JA: A five-gene expression signature to predict progression in T1G3 bladder cancer. Eur J Cancer. 64:127–136. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu J, Wu J, Pei X, Tan Z, Shi J and Lubman DM: Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma. PLoS One. 12:e01750392017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Peng X, Hu Z, Zhao Q, He J, Li J and Zhong X: Effects of over-expression of ANXA10 gene on proliferation and apoptosis of hepatocellular carcinoma cell line HepG2. J Huazhong Univ Sci Technolog Med Sci. 32:669–674. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Xu A, Jia S and Huang J: Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma. Oncol Lett. 17:4222–4228. 2019.PubMed/NCBI | |
|
Liu C, Ren YF, Dong J, Ke MY, Ma F, Monga SPS, Wu R, Lv Y and Zhang XF: Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma. Cancer Lett. 410:20–31. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng B, Zhu YJ, Wang HY and Chen L: Gender disparity in hepatocellular carcinoma (HCC): Multiple underlying mechanisms. Sci China Life Sci. 60:575–584. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM and Karin M: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 317:121–124. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kanda T, Takahashi K, Nakamura M, Nakamoto S, Wu S, Haga Y, Sasaki R, Jiang X and Yokosuka O: Androgen receptor could be a potential therapeutic target in patients with advanced hepatocellular carcinoma. Cancers (Basel). 9:pii432017. View Article : Google Scholar | |
|
Yeh SH and Chen PJ: Gender disparity of hepatocellular carcinoma: The roles of sex hormones. Oncology. 78 (Suppl 1):S172–S179. 2010. View Article : Google Scholar | |
|
Torosyan Y, Simakova O, Naga S, Mezhevaya K, Leighton X, Diaz J, Huang W, Pollard H and Srivastava M: Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cells. Int J Cancer. 125:2528–2539. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Grewal T, Wason SJ, Enrich C and Rentero C: Annexins-insights from knockout mice. Biol Chem. 397:1031–1053. 2016. View Article : Google Scholar : PubMed/NCBI |
