Open Access

Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia

  • Authors:
    • Zhihui Guan
    • Yuwei Song
    • Jinguo Ma
    • Feng Li
    • Xiaojun Zhao
    • Guodong Liang
    • Haiquan An
    • Jinxian Pu
  • View Affiliations

  • Published online on: November 1, 2019     https://doi.org/10.3892/ol.2019.11039
  • Pages: 6379-6384
  • Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Long non‑coding (lnc)RNA NCK1 antisense RNA 1 (NCK1‑AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown. It was revealed in the present study that plasma NCK1‑AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Upregulation of NCK1‑AS1 distinguished patients with PC from patients with BPH and healthy controls. Overexpression of NCK1‑AS1 led to significantly upregulated transforming growth factor (TGF)‑β1, while TGF‑β1 overexpression failed to significantly affect NCK1‑AS1 in PC cells. NCK1‑AS1 overexpression led to promoted migration and invasion. TGF‑β inhibitor played an opposite role and attenuated the effects of NCK1‑AS1 overexpression. Therefore, NCK1‑AS1 may upregulate TGF‑β1 to promote PC.
View Figures
View References

Related Articles

Journal Cover

December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guan Z, Song Y, Ma J, Li F, Zhao X, Liang G, An H and Pu J: Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia. Oncol Lett 18: 6379-6384, 2019
APA
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G. ... Pu, J. (2019). Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia. Oncology Letters, 18, 6379-6384. https://doi.org/10.3892/ol.2019.11039
MLA
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G., An, H., Pu, J."Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia". Oncology Letters 18.6 (2019): 6379-6384.
Chicago
Guan, Z., Song, Y., Ma, J., Li, F., Zhao, X., Liang, G., An, H., Pu, J."Altered expression of lncRNA NCK1‑AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia". Oncology Letters 18, no. 6 (2019): 6379-6384. https://doi.org/10.3892/ol.2019.11039