Open Access

HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer

  • Authors:
    • Warne Pedro De Andrade
    • Letícia Da Conceição Braga
    • Nikole Gontijo Gonçales
    • Luciana Maria Silva
    • Agnaldo Lopes Da Silva Filho
  • View Affiliations

  • Published online on: November 14, 2019     https://doi.org/10.3892/ol.2019.11095
  • Pages: 359-367
  • Copyright: © De Andrade et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with the presence of chemoresistance contributing to the poor prognosis. Heat Shock Proteins (HSPs) genes are activated in response to pathophysiological stress and serve a role in a variety of stages in carcinogenesis, acting primarily as anti‑apoptotic agents and in chemotherapy resistance in a variety of tumor types. The current study evaluated the HSP gene expression profile in women with ovarian cancer (OC) and their correlation with clinical and pathological aspects of patients with OC. A total of 51 patients included in the current study were divided into four groups: Primary Epithelial Ovarian Cancer (EOC; n=14), metastatic EOC (n=11), ovarian serous cystadenoma (n=7) and no evidence of ovarian malignancy or control groups (n=19). RNA extraction and reverse transcription‑quantitative (RT‑q) PCR was then performed on the samples obtained. RT‑qPCR was performed to compare TNF receptor associated protein 1 (TRAP1), heat shock protein family (HSP) HSPB1, HSPD1, HSPA1A and HSPA1L expression in primary and metastatic EOCs. TRAP1, HSPB1, HSPD1, HSPA1A and HSPA1L gene expression did not differ among groups. HSPA1A, HSPA1L and TRAP1 were revealed to be underexpressed in the primary and metastatic EOC groups, with HSPA1L exhibiting the lowest expression. TRAP1 expression was higher in tumors at stages I/II compared with those at stages III/IV. No correlation was exhibited between HSP expression and age, menarche, menopause, parity, period after menopause initiation, cytoreduction, CA‑125 or overall and disease‑free survival. HSPA1A was negatively correlated with the risk of mortality from OC. The results indicated that the downregulation of HSPA1A, HSPA1L and TRAP1 could be associated with the clinical prognostic features of women with EOC.
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January-2020
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Spandidos Publications style
De Andrade WP, Braga LD, Gonçales NG, Silva LM and Da Silva Filho AL: HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer. Oncol Lett 19: 359-367, 2020.
APA
De Andrade, W.P., Braga, L.D., Gonçales, N.G., Silva, L.M., & Da Silva Filho, A.L. (2020). HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer. Oncology Letters, 19, 359-367. https://doi.org/10.3892/ol.2019.11095
MLA
De Andrade, W. P., Braga, L. D., Gonçales, N. G., Silva, L. M., Da Silva Filho, A. L."HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer". Oncology Letters 19.1 (2020): 359-367.
Chicago
De Andrade, W. P., Braga, L. D., Gonçales, N. G., Silva, L. M., Da Silva Filho, A. L."HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer". Oncology Letters 19, no. 1 (2020): 359-367. https://doi.org/10.3892/ol.2019.11095