Application of diffusion tensor tractography in the surgical treatment of brain tumors located in functional areas

Zhang,Hongliang; Feng,Yugong; Cheng,Lei; Liu,Jie; Li,Huanting; Jiang,Hong

doi:10.3892/ol.2019.11167

Application of diffusion tensor tractography in the surgical treatment of brain tumors located in functional areas

Authors:
- Hongliang Zhang
- Yugong Feng
- Lei Cheng
- Jie Liu
- Huanting Li
- Hong Jiang
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Affiliations: Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266005, P.R. China, Department of Physiology, Shandong Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China
Published online on: November 29, 2019 https://doi.org/10.3892/ol.2019.11167
Pages: 615-622
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to explore the application of diffusion tensor tractography (DTT) in the preoperative planning and prognostic evaluation of tumors located in the functional areas of the brain. A total of 42 patients diagnosed with intracranial tumors were randomly assigned to either the trial or the control group. DT imaging (DTI) was performed on the basis of preoperative conventional magnetic resonance imaging (MRI) and analyzed for patients in the trial group. Patients in the control group underwent only routine MRI scans. The effect of DTT on the prognosis of patients was evaluated by tumor resection rate and quality of life evaluation using Karnofsky performance score (KPS) comparison between the trial and control groups. There were no significant differences for total tumor removal rate in the trial group (85.71%) compared with that in the control group (71.43%) (P>0.05). The rate of postoperative symptom improvement in the trial group (85.71%) was significantly higher compared with that in the control group (47.62%) (P<0.05). The KPS value of the trial group was significantly higher postoperatively (78.57±17.40) compared with that preoperatively (66.67±16.23) (P<0.05). The KPS value of the control group postoperatively (72.38±19.21) was significantly higher compared with that preoperatively (66.67±16.00) (P<0.05). The postoperative KPS improvement rate [postoperative value‑preoperative value)/preoperative value] of the trial group was significantly higher compared with that in the control group. In conclusion, the use of DTT is an effective supplement to traditional MRI, with particular relevance in preoperative planning, particularly for tumors in the functional area of the brain, and can significantly improve the prognostic function of patients.

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