mi‑R4435‑2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2

Hu,Jinghui; Wang,Li; Zhao,Wei; Huang,Yujie; Wang,Zhe; Shen,Heping

doi:10.3892/ol.2019.11204

mi‑R4435‑2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2

Authors:
- Jinghui Hu
- Li Wang
- Wei Zhao
- Yujie Huang
- Zhe Wang
- Heping Shen
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Affiliations: Department of Gynecology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Gynecology and Οbstetrics, Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China, Department of Gynecology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China
Published online on: December 11, 2019 https://doi.org/10.3892/ol.2019.11204
Pages: 1305-1309
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the involvement of long noncoding RNA mi‑R4435‑2HG in ovarian carcinoma. mi‑R4435‑2HG and Rho‑associated protein kinase 2 (ROCK2) were demonstrated to both be upregulated in ovarian carcinoma. mi‑R4435‑2HG and ROCK2 were positively correlated in both tumor and healthy tissues. mi‑R4435‑2HG overexpression mediated the upregulation of ROCK2, while upregulation of ROCK2 did not affect mi‑R4435‑2HG. Overexpression of mi‑R4435‑2HG and ROCK2 led to promoted proliferation and inhibited apoptosis of cancer cells, while mi‑R4435‑2HG and ROCK2 knockdown had the opposite effect. In addition, ROCK2 knockdown attenuated the effects of mi‑R4435‑2HG overexpression on cancer cell proliferation and apoptosis. Therefore, mi‑R4435‑2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2.

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