Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Stanciu,Adina   E.; Zamfir-Chiru-Anton,Adina; Stanciu,Marcel   M.; Stoian,Anca   Pantea; Jinga,Viorel; Nitipir,Cornelia; Bucur,Alexandru; Pituru,Teodora   S.; Arsene,Andreea   L.; Dragoi,Cristina   M.; Hainarosie,Razvan; Nicolae,Alina   C.; Gherghe,Mirela; Gheorghe,Dan   C.; Spandidos,Demetrios   A.; Tsatsakis,Aristidis; Papasavva,Maria; Drakoulis,Nikolaos

doi:10.3892/ol.2019.11215

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Authors:
- Adina E. Stanciu
- Adina Zamfir-Chiru-Anton
- Marcel M. Stanciu
- Anca Pantea Stoian
- Viorel Jinga
- Cornelia Nitipir
- Alexandru Bucur
- Teodora S. Pituru
- Andreea L. Arsene
- Cristina M. Dragoi
- Razvan Hainarosie
- Alina C. Nicolae
- Mirela Gherghe
- Dan C. Gheorghe
- Demetrios A. Spandidos
- Aristidis Tsatsakis
- Maria Papasavva
- Nikolaos Drakoulis
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Affiliations: Department of Carcinogenesis and Molecular Biology, Institute of Oncology Bucharest, 022328 Bucharest, Romania, ENT Department, Grigore Alexandrescu Children's Emergency Hospital and Coltea Clinical Hospital, 011743 Bucharest, Romania, Electrical Engineering Faculty, University Politehnica of Bucharest, 060042 Bucharest, Romania, Department of Diabetes Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Oncology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Oral and Maxillo-facial Surgery, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Biochemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania, ENT Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Radiology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Forensic Sciences and Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece
Published online on: December 13, 2019 https://doi.org/10.3892/ol.2019.11215
Pages: 1537-1543
Copyright: © Stanciu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its anticancer properties. This study aimed to reveal the clinical significance of serum melatonin levels in predicting the severity of oral squamous cell carcinoma (OSCC). For this purpose, 40 male patients with OSCC and 30 healthy subjects were enrolled in this study. The serum levels of melatonin were determined by ELISA. The results revealed that the melatonin concentrations were significantly lower in the patients with OSCC compared with the controls (18.2 vs. 47.6 pg/ml, P<0.001). In addition, the serum melatonin levels had a high predictive accuracy for discriminating patients with OSCC with T-depth of invasion (DOI) II from the healthy controls (89.1%), as well as in discriminating patients with OSCC with nodal metastasis from those without nodal metastasis (83.8%). On the whole, the findings of this study suggest that the serum melatonin concentrations are closely related to the severity of OSCC and may thus be used to assess the different stages of oral cancer objectively and accurately. The present study also supports the conclusion that melatonin may be a potential therapeutic agent for use in the treatment of patients with OSCC.

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