Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis

  • Authors:
    • Tuy An Trinh
    • Dahae Lee
    • Seonju Park
    • Seung Hyun Kim
    • Jae Gyu Park
    • Ji Hwan Kim
    • Ki Sung Kang
  • View Affiliations

  • Published online on: January 14, 2019     https://doi.org/10.3892/ol.2019.9926
  • Pages: 2953-2959
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Abstract

Rheum undulatum L. (R. undulatum) is a medicinal plant used for the treatment of inflammatory diseases in East Asian countries. Numerous stilbenes isolated from R. undulatum have been revealed to possess anticancer effects. The aim of the present study was to evaluate the effect of extracts and compounds isolated from R. undulatum on human gastric cancer cell viability and to elucidate their molecular mechanism of action on the apoptosis pathway. The results demonstrated that aloe‑emodin and chrysophanol 1‑O‑β‑D‑glucopyranoside, isolated from the methanolic extract of dried rhizomes of R. undulatum, exhibited anti‑proliferative effects on the human gastric carcinoma cell line AGS, with IC50 values of 84.66±0.44 and 68.28±0.29 µM, respectively. The percentage of apoptotic cells increased significantly following treatment with each compound at a concentration of 100 µM, compared with that in the non‑treated group in the image‑based cytometry assay. Western blot analysis revealed that these compounds activated the caspase cascade and inhibited B‑cell lymphoma‑2, an anti‑apoptotic protein.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Trinh TA, Lee D, Park S, Kim SH, Park JG, Kim JH and Kang KS: Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncol Lett 17: 2953-2959, 2019.
APA
Trinh, T.A., Lee, D., Park, S., Kim, S.H., Park, J.G., Kim, J.H., & Kang, K.S. (2019). Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncology Letters, 17, 2953-2959. https://doi.org/10.3892/ol.2019.9926
MLA
Trinh, T. A., Lee, D., Park, S., Kim, S. H., Park, J. G., Kim, J. H., Kang, K. S."Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis". Oncology Letters 17.3 (2019): 2953-2959.
Chicago
Trinh, T. A., Lee, D., Park, S., Kim, S. H., Park, J. G., Kim, J. H., Kang, K. S."Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis". Oncology Letters 17, no. 3 (2019): 2953-2959. https://doi.org/10.3892/ol.2019.9926