Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2

Liu,Hong; Zang,Lili; Zhao,Jun; Wang,Zhaolin; Li,Lingyun

doi:10.3892/ol.2020.11424

Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2

Authors:
- Hong Liu
- Lili Zang
- Jun Zhao
- Zhaolin Wang
- Lingyun Li
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Affiliations: Department of Liver Disease, Yantai Infectious Diseases Hospital, Yantai, Shangdong 264001, P.R. China, Department of Gastroenterology, Yantai Yu Huang Ding Hospital, Yantai, Shangdong 264003, P.R. China, Department of Information and Electrical Engineering, Ludong University, Yantai, Shangdong 264025, P.R. China
Published online on: March 3, 2020 https://doi.org/10.3892/ol.2020.11424
Pages: 3165-3172
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paeoniflorin (PF) has been demonstrated to exert tumor suppressive functions in various types of human cancer. However, the mechanisms of PF‑mediated anti‑tumor activity have not been fully elucidated. S‑phase kinase associated protein 2 (Skp2) has been characterized as an oncoprotein that contributes to carcinogenesis. Therefore, the inhibition of Skp2 may be a useful approach for the treatment of various types of human cancer. The present study explored whether PF inhibited the expression of Skp2 in liver cancer cells, leading to cell viability inhibition, induction of apoptosis, and suppression of migration and invasion. PF treatment led to inhibition of Skp2 expression in liver cancer cells. The overexpression of Skp2 abolished PF‑mediated anti‑cancer activity, whereas the downregulation of Skp2 enhanced this type of activity. The data indicated that PF may be considered as a novel inhibitor of Skp2 in liver cancer cells.

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