Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer

  • Authors:
    • Shuo Wang
    • Jun Zhang
    • Fan‑Jie Meng
    • Yi‑Jie Yan
    • Bin Wang
    • Zhi‑Yu Guan
  • View Affiliations

  • Published online on: April 3, 2020     https://doi.org/10.3892/ol.2020.11508
  • Pages: 4142-4150
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Abstract

Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑associated mortality. Therapies targeting programmed cell death 1 ligand 1 (PD1L1) have promising effects on NSCLC. However, resistance to targeted therapy has become the main problem and the underling molecular mechanism remains unclear. In the present study, the expression of PD1L1 in NSCLC was determined and the association with clinicopathological characteristics was analyzed. A combination therapy was also constructed, including pembrolizumab (Pem) and iodine‑125 (125I), which represented an efficient strategy for the treatment of NSCLC. The expression of PD1L1 was upregulated in NSCLC tissues and positively correlated with the Ki‑67 index, pathological subtypes and risk stages. A higher level of PD1L1 expression was associated with poorer survival in patients with NSCLC, which could be used as a prognostic indicator. When NSCLC cells were cultured in the presence of Pem and 125I seeds, the combination treatment significantly abrogated the tumor proliferation and aggressiveness through the inhibition of matrix metalloproteinase‑2 and ‑9 secretion. Flow cytometry analysis revealed pembrolizumab combined with 125I contributed to a higher rate of apoptosis and cell cycle arrest, indicating that the combination treatment improved the resistance to immunotherapy. Furthermore, the associated molecular mechanism was the dysregulation of ADAM metallopeptidase domain 17. The findings from the present study revealed that PD1L1 could be used as a predictive biomarker, and the application of combination treatment of pembrolizumab and 125I showed promising effects on NSCLC.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang S, Zhang J, Meng FJ, Yan YJ, Wang B and Guan ZY: Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer. Oncol Lett 19: 4142-4150, 2020.
APA
Wang, S., Zhang, J., Meng, F., Yan, Y., Wang, B., & Guan, Z. (2020). Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer. Oncology Letters, 19, 4142-4150. https://doi.org/10.3892/ol.2020.11508
MLA
Wang, S., Zhang, J., Meng, F., Yan, Y., Wang, B., Guan, Z."Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer". Oncology Letters 19.6 (2020): 4142-4150.
Chicago
Wang, S., Zhang, J., Meng, F., Yan, Y., Wang, B., Guan, Z."Combination of pembrolizumab and 125I attenuates the aggressiveness of non‑small cell lung cancer". Oncology Letters 19, no. 6 (2020): 4142-4150. https://doi.org/10.3892/ol.2020.11508