Open Access

NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial‑mesenchymal transition

  • Authors:
    • Ying Guo
    • Jianhua Zhai
    • Jing Zhang
    • Huifang Zhou
  • View Affiliations

  • Published online on: April 10, 2020     https://doi.org/10.3892/ol.2020.11527
  • Pages: 3711-3718
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In recent years, neutrophil gelatinase‑associated lipocalin (NGAL) has been considered to be a key molecule in different cancer types and its carcinogenesis may be related to the NGAL/MMP‑9 complex. However, its expression pattern and role in nasopharyngeal carcinoma (NPC) has rarely been reported. In the current study, 158 tumor tissues from NPC patients were collected and immunohistochemistry was performed to determine the NGAL protein expression, to investigate the correlation between its expression and clinical and pathological parameters using Chi square analysis. Furthermore, by over‑expressing NGAL in NPC cell lines, biological alteration of NPC cells with respect to cell proliferation, migration and invasion was analyzed. Results suggested that high expression of NGAL predicts better prognosis and longer survival. Overexpression of NGAL significantly reduced the proliferation and migration of NPC cells, and induced the apoptosis by activating caspase 3, 8 and 9, and blocking epithelial‑mesenchymal transition by inhibiting mothers against decapentaplegic homolog 2/3 phosphorylation.
View Figures
View References

Related Articles

Journal Cover

June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Zhai J, Zhang J and Zhou H: NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial‑mesenchymal transition. Oncol Lett 19: 3711-3718, 2020.
APA
Guo, Y., Zhai, J., Zhang, J., & Zhou, H. (2020). NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial‑mesenchymal transition. Oncology Letters, 19, 3711-3718. https://doi.org/10.3892/ol.2020.11527
MLA
Guo, Y., Zhai, J., Zhang, J., Zhou, H."NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial‑mesenchymal transition". Oncology Letters 19.6 (2020): 3711-3718.
Chicago
Guo, Y., Zhai, J., Zhang, J., Zhou, H."NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial‑mesenchymal transition". Oncology Letters 19, no. 6 (2020): 3711-3718. https://doi.org/10.3892/ol.2020.11527