![Open Access](/resources/images/iconopenaccess.png)
Circular RNAs in gastric cancer: Biomarkers for early diagnosis (Review)
- Authors:
- Chun‑Mei Yang
- Guang‑Lei Qiao
- Li‑Na Song
- Shisan Bao
- Li‑Jun Ma
-
Affiliations: Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China - Published online on: May 14, 2020 https://doi.org/10.3892/ol.2020.11623
- Pages: 465-473
-
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
![]() |
![]() |
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhu L, Qin J, Wang J, Guo T, Wang Z and Yang J: Early gastric cancer: Current advances of endoscopic diagnosis and treatment. Gastroenterol Res Pract. 2016:96380412016. View Article : Google Scholar : PubMed/NCBI | |
Huang RJ, Choi AY, Truong CD, Yeh MM and Hwang JH: Diagnosis and management of gastric intestinal metaplasia: Current status and future directions. Gut Liver. 15:596–603. 2019. View Article : Google Scholar | |
Hentze MW and Preiss T: Circular RNAs: Splicing's enigma variations. EMBO J. 32:923–925. 2013. View Article : Google Scholar : PubMed/NCBI | |
Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, Wu YM, Dhanasekaran SM, Engelke CG, Cao X, et al: The landscape of circular RNA in cancer. Cell. 176:869–881. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wilusz JE and Sharp PA: Molecular biology. A circuitous route to noncoding RNA. Science. 340:440–441. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014. View Article : Google Scholar : PubMed/NCBI | |
Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA and Goodall GJ: The RNA binding protein quaking regulates formation of circRNAs. Cell. 160:1125–1134. 2015. View Article : Google Scholar : PubMed/NCBI | |
Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL and Sabeti PC: Strand-Specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. BMC Genomics. 16:4542015. View Article : Google Scholar : PubMed/NCBI | |
Lu T, Cui L, Zhou Y, Zhu C, Fan D, Gong H, Zhao Q, Zhou C, Zhao Y, Lu D, et al: Transcriptome-Wide investigation of circular RNAs in rice. RNA. 21:2076–2087. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR and Matera AG: Metazoan tRNA introns generate stable circular RNAs in vivo. RNA. 21:1554–1565. 2015. View Article : Google Scholar : PubMed/NCBI | |
Schmidt CA, Noto JJ, Filonov GS and Matera AG: A method for expressing and imaging abundant, stable, circular RNAs in vivo using tRNA splicing. Methods Enzymol. 572:215–236. 2016. View Article : Google Scholar : PubMed/NCBI | |
Jin M, Shi C, Yang C, Liu J and Huang G: Upregulated CircRNA ARHGAP10 Predicts an unfavorable prognosis in NSCLC through regulation of the miR-150-5p/GLUT-1 axis. Mol Ther Nucleic Acids. 18:219–231. 2019. View Article : Google Scholar : PubMed/NCBI | |
Ye F, Gao G, Zou Y, Zheng S, Zhang L, Ou X, Xie X and Tang H: CircFBXW7 inhibits malignant progression by sponging miR-197-3p and encoding a 185-aa protein in triple-negative breast cancer. Mol Ther Nucleic Acids. 18:88–98. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhu K, Zhan H, Peng Y, Yang L, Gao Q, Jia H, Dai Z, Tang Z, Fan J and Zhou J: Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma. Carcinogenesis. 19:1542019. | |
Chen J, Chen T, Zhu Y, Li Y, Zhang Y, Wang Y, Li X, Xie X, Wang J, Huang M, et al: CircPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma. J Exp Clin Cancer Res. 38:3982019. View Article : Google Scholar : PubMed/NCBI | |
Xu G, Chen Y, Fu M, Zang X, Cang M, Niu Y, Zhang W, Zhang Y, Mao Z, Shao M, et al: Circular RNA CCDC66 promotes gastric cancer progression by regulating c-Myc and TGF-β signaling pathways. J Cancer. 11:2759–2768. 2020. View Article : Google Scholar : PubMed/NCBI | |
Song H, Xu Y, Xu T, Fan R, Jiang T, Cao M, Shi L and Song J: CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p. Biomed Pharmacother. 126:1099412020. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Chang X, Zhai T, Yu J, Wang W, Du A and Liu N: A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis. Biochem Biophys Res Commun. 14:841–849. 2020. View Article : Google Scholar | |
Hu K, Qin X, Shao Y, Zhou Y, Ye G and Xu S: Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1. Mol Cell Probes. 56:1015622020. View Article : Google Scholar | |
Ren S, Liu J, Feng Y, Li Z, He L, Li L, Cao X, Wang Z and Zhang Y: Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia. J Exp Clin Cancer Res. 38:3882019. View Article : Google Scholar : PubMed/NCBI | |
Liu Q, Zhang W, Wu Z, Liu H, Hu H, Shi H, Li S and Zhang X: Construction of a circular RNA-microRNA-messengerRNA regulatory network in stomach adenocarcinoma. J Cell Biochem. 12:1317–1331. 2019. | |
Bi J, Liu H, Dong W, Xie W, He Q, Cai Z, Huang J and Lin T: Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence. Mol Cancer. 18:1332019. View Article : Google Scholar : PubMed/NCBI | |
Huang H, Wei L, Qin T, Yang N, Li Z and Xu Z: Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-κB signals. Cancer Biol Ther. 20:73–80. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chung DJ, Wang CJ, Yeh CW and Tseng TH: Inhibition of the proliferation and invasion of C6 glioma cells by tricin via the upregulation of focal-adhesion-kinase-targeting MicroRNA-7. J Agric Food Chem. 66:6708–6716. 2018. View Article : Google Scholar : PubMed/NCBI | |
Pan M, Li M, You C, Zhao F, Guo M, Xu H, Li L, Wang L and Dou J: Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation. J Cell Physiol. 235:1405–1416. 2019. View Article : Google Scholar : PubMed/NCBI | |
Ye T, Yang M, Huang D, Wang X, Xue B, Tian N, Xu X, Bao L, Hu H, Lv T and Huang Y: MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin Cancer Res. 38:552019. View Article : Google Scholar : PubMed/NCBI | |
Ling Y, Cao C, Li S, Qiu M, Shen G, Chen Z, Yao F and Chen W: TRIP6, as a target of miR-7, regulates the proliferation and metastasis of colorectal cancer cells. Biochem Biophys Res Commun. 514:231–238. 2019. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Zheng F, Xiao X, Xie F, Tao D, Huang C, Liu D, Wang M, Wang L, Zeng F and Jiang G: CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. EMBO Rep. 18:1646–1659. 2017. View Article : Google Scholar : PubMed/NCBI | |
Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016. View Article : Google Scholar : PubMed/NCBI | |
Meng Q, Li S, Liu Y, Zhang S, Jin J, Zhang Y, Guo C, Liu B and Sun Y: Circular RNA circSCAF11 accelerates the glioma tumorigenesis through the miR-421/SP1/VEGFA axis. Mol Ther Nucleic Acids. 17:669–677. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yan Y, Fu G, Ye Y and Ming L: Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer. Scand J Gastroenterol. 52:499–504. 2017. View Article : Google Scholar : PubMed/NCBI | |
Thomas LF and Sætrom P: Circular RNAs are depleted of polymorphisms at microRNA binding sites. Bioinformatics. 30:2243–2246. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zhao ZJ and Shen J: Circular RNA participates in the carcinogenesis and the malignant behavior of cancer. RNA Biol. 14:514–521. 2017. View Article : Google Scholar : PubMed/NCBI | |
Lu J, Wang YH, Huang XY, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, Huang CM, Zheng CH and Li P: Circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p. J Cell Physiol. 5:102020. | |
Li H, Wei X, Yang J, Dong D, Hao D, Huang Y, Lan X, Plath M, Lei C, Ma Y, et al: CircFGFR4 promotes differentiation of myoblasts via binding miR-107 to relieve its inhibition of Wnt3a. Mol Ther Nucleic Acids. 11:272–283. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: Circrna biogenesis competes with pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z and Liu Y: TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway. J Hematol Oncol. 10:522017. View Article : Google Scholar : PubMed/NCBI | |
Yang ZG, Awan FM, Du WW, Zeng Y, Lyu J, Wu, Gupta S, Yang W and Yang BB: The Circular RNA interacts with stat3, increasing its nuclear translocation and wound repair by modulating Dnmt3a and miR-17 function. Mol Ther. 25:2062–2074. 2017. View Article : Google Scholar : PubMed/NCBI | |
Liu KS, Pan F, Mao XD, Liu C and Chen J: Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases. Am J Transl Res. 11:1–15. 2019.PubMed/NCBI | |
Zhang Y, Liang W, Zhang P, Chen J, Qian H, Zhang X and Xu W: Circular RNAs: Emerging cancer biomarkers and targets. J Exp Clin Cancer Res. 36:1522017. View Article : Google Scholar : PubMed/NCBI | |
Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI | |
Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z and Sharpless NE: Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 6:e10012332010. View Article : Google Scholar : PubMed/NCBI | |
Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL and Gorospe M: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol. 14:361–369. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang Y and Wang Z: Efficient backsplicing produces translatablecircular mRNAs. RNA. 21:172–179. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-Intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li F, Ma K, Sun M and Shi S: Identification of the tumor-suppressive function of circular RNA ITCH in glioma cells through sponging miR-214 and promoting linear ITCH expression. Am J Transl Res. 10:1373–1386. 2018.PubMed/NCBI | |
Ouyang Y, Li Y, Huang Y, Li X, Zhu Y, Long Y, Wang Y, Guo X and Gong K: CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2. J Cell Physiol. 234:10458–10469. 2019. View Article : Google Scholar : PubMed/NCBI | |
Fry AM, O'Regan L, Sabir SR and Bayliss R: Cell cycle regulation by the NEK family of protein kinases. J Cell Sci. 125:4423–4433. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, et al: Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett. 388:208–219. 2017. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Liu Y, Bian Z, Zhang J, Zhang R, Chen X, Huang Y, Wang Y and Zhu J: Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 (Kip1) axis. Mol Cancer. 17:1512018. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Liu H, Li W, Yu J, Li J, Shen Z, Ye G, Qi X and Li G: CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. Aging (Albany NY). 9:1585–1594. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Shen J and Jiang YL: Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1. Cell Biosci. 8:582018. View Article : Google Scholar : PubMed/NCBI | |
Yin QF, Yang L, Zhang Y, Xiang JF, Wu YW, Carmichael GG and Chen LL: Long noncoding RNAs with snoRNA ends. Mol Cell. 48:219–230. 2012. View Article : Google Scholar : PubMed/NCBI | |
Han B, Chao J and Yao H: Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacol Ther. 187:31–44. 2018. View Article : Google Scholar : PubMed/NCBI | |
Sun HD, Xu ZP, Sun ZQ, Zhu B, Wang Q, Zhou J, Jin H, Zhao A, Tang WW and Cao XF: Down-Regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep. 8:101112018. View Article : Google Scholar : PubMed/NCBI | |
Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, et al: A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 9:44752018. View Article : Google Scholar : PubMed/NCBI | |
Huang H, Weng H and Chen J: m6A Modification in coding and non-coding RNAs: Roles and therapeutic implications in cancer. Cancer Cell. 37:270–288. 2020. View Article : Google Scholar : PubMed/NCBI | |
Wu P, Mo Y, Peng M, Tang T, Zhong Y, Deng X, Xiong F, Guo C, Wu X, Li Y, et al: Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA. Mol Cancer. 19:222020. View Article : Google Scholar : PubMed/NCBI | |
Fang J, Hong H, Xue X, Zhu X, Jiang L, Qin M, Liang H and Gao L: A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett. 442:222–232. 2019. View Article : Google Scholar : PubMed/NCBI | |
Warburg O, Wind F and Negelein E: The metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927. View Article : Google Scholar : PubMed/NCBI | |
Kimmelman AC and White E: Autophagy and tumor metabolism. Cell Metab. 25:1037–1043. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, Xu P, Sun G, Xu J, Lv J and Xu Z: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 18:202019. View Article : Google Scholar : PubMed/NCBI | |
Heras-Sandoval D, Perez-Rojas JM, Hernandez-Damian J and Pedraza-Chaverri J: The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal. 26:2694–2701. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X and Guo WJ: MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway. Biochem Biophys Res Commun. 501:1068–1073. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang H, Zhu L, Bai M, Liu Y, Zhan Y, Deng T, Yang H, Sun W, Wang X, Zhu K, et al: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer. 144:2501–2515. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wei J, Wei W, Xu H, Wang Z, Gao W, Wang T, Zheng Q, Shu Y and De W: Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer. Cancer Biomark. 27:139–145. 2019. View Article : Google Scholar | |
Shao Y, Ye M, Li Q, Sun W, Ye G, Zhang X, Yang Y, Xiao B and Guo J: LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer. Oncotarget. 7:37812–37824. 2016. View Article : Google Scholar : PubMed/NCBI | |
Park YM, Kim JK, Baik SJ, Park JJ, Youn YH and Park H: Clinical risk assessment for gastric cancer in asymptomatic population after a health check-up: An individualized consideration of the risk factors. Medicine (Baltimore). 95:e53512016. View Article : Google Scholar : PubMed/NCBI | |
Shao Y, Li J, Lu R, Li T, Yang Y, Xiao B and Guo J: Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med. 6:1173–1180. 2017. View Article : Google Scholar : PubMed/NCBI | |
Duffy MJ, Lamerz R, Haglund C, Nicolini A, Kalousová M, Holubec L and Sturgeon C: Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. Int J Cancer. 134:2513–2522. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zhao Q, Chen S, Li T, Xiao B and Zhang X: Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal. 32:e223332018. View Article : Google Scholar : PubMed/NCBI | |
Lu J, Zhang PY, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, Huang CM, Li P and Zheng CH: Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer. J Clin Lab Anal. 33:e227262019. View Article : Google Scholar : PubMed/NCBI | |
Tang W, Fu K, Sun H, Rong D, Wang H and Cao H: CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol Cancer. 17:1372018. View Article : Google Scholar : PubMed/NCBI | |
Yang W, Gu J, Wang X, Wang Y, Feng M, Zhou D, Guo J and Zhou M: Inhibition of circular RNA CDR1as increases chemosensitivity of 5-FU-resistant BC cells through up-regulating miR-7. J Cell Mol Med. 23:3166–3177. 2019. View Article : Google Scholar : PubMed/NCBI | |
Pan H, Li T, Jiang Y, Pan C, Ding Y, Huang Z, Yu H and Kong D: Overexpression of circular RNA ciRS-7 abrogates the tumor suppressive effect of miR-7 on gastric cancer via PTEN/PI3K/AKT signaling pathway. J Cell Biochem. 119:440–446. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang H, Wang X, Huang H, Wang Y, Zhang F and Wang S: Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP). Artif Cells Nanomed Biotechnol. 47:308–318. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lencz T, Guha S, Liu C, Rosenfeld J, Mukherjee S, De Rosse P, John M, Cheng L, Zhang C, Badner JA, et al: Genome-Wide association study implicates NDST3 in schizophrenia and bipolar disorder. Nat Commun. 4:27392013. View Article : Google Scholar : PubMed/NCBI | |
Sun J, Li J, Zhang W, Zhang J, Sun S, Li G, Song H and Wan D: MicroRNA-509-3p inhibits cancer cell proliferation and migration via upregulation of XIAP in gastric cancer cells. Oncol Res. 25:455–461. 2017. View Article : Google Scholar : PubMed/NCBI | |
Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L and Huang Q: Circular RNAs expression profiles in human gastric cancer. Sci Rep. 7:90602017. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, et al: Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 110:32018. View Article : Google Scholar | |
Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC and Mullen AC: Genome-Wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell Rep. 20:2262–2276. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X and Huang S: Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res. 25:981–984. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li WH, Song YC, Zhang H, Zhou ZJ, Xie X, Zeng QN, Guo K, Wang T, Xia P and Chang DM: Decreased expression of Hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers. 2017:45876982017. View Article : Google Scholar : PubMed/NCBI | |
Li J, Zhen L, Zhang Y, Zhao L, Liu H, Cai D, Chen H, Yu J, Qi X and Li G: Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Onco Targets Ther. 10:3521–3529. 2017. View Article : Google Scholar : PubMed/NCBI | |
Huang M, He YR, Liang LC, Huang Q and Zhu ZQ: Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 23:6330–6338. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R and Guo J: Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer. 116:626–633. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li T, Shao Y, Fu L, Xie Y, Zhu L, Sun W, Yu R, Xiao B and Guo J: Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl). 96:85–96. 2018. View Article : Google Scholar : PubMed/NCBI | |
Fang Y, Ma M, Wang J, Liu X and Wang Y: Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Tumour Biol. 39:13933838142017. View Article : Google Scholar | |
Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B and Guo J: Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta. 444:132–136. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lu R, Shao Y, Ye G, Xiao B and Guo J: Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. Tumour Biol. 39:13933854892017. View Article : Google Scholar | |
Sun H, Tang W, Rong D, Jin H, Fu K, Zhang W, Liu Z, Cao H and Cao X: Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark. 21:299–306. 2018. View Article : Google Scholar : PubMed/NCBI | |
Xie Y, Shao Y, Sun W, Ye G, Zhang X, Xiao B and Guo J: Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values. Biomark Med. 12:11–20. 2018. View Article : Google Scholar : PubMed/NCBI | |
Rong D, Dong C, Fu K, Wang H, Tang W and Cao H: Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther. 11:2753–2761. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhong S, Wang J, Hou J, Zhang Q, Xu H, Hu J, Zhao J and Feng J: Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells. Epigenomics. 10:1301–1313. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wei H, Pan L, Tao D and Li R: Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. Biochem Biophys Res Commun. 503:56–61. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tian M, Chen R, Li T and Xiao B: Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. J Clin Lab Anal. 32:32018. View Article : Google Scholar | |
Chen S, Li T, Zhao Q, Xiao B and Guo J: Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta. 466:167–171. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhou LH, Yang YC, Zhang RY, Wang P, Pang MH and Liang LQ: CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT. Eur Rev Med Pharmacol Sci. 22:2297–2303. 2018.PubMed/NCBI | |
Sun H, Xi P, Sun Z, Wang Q, Zhu B, Zhou J, Jin H, Zheng W, Tang W, Cao H and Cao X: Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression. Cancer Manag Res. 10:5725–5734. 2018. View Article : Google Scholar : PubMed/NCBI | |
Shen F, Liu P, Xu Z, Li N, Yi Z, Tie X, Zhang Y and Gao L: CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer. J Biochem. 165:27–36. 2019. View Article : Google Scholar : PubMed/NCBI |