![Open Access](/resources/images/iconopenaccess.png)
Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer (Review)
- Authors:
- Changming Wang
- Yan Liu
- Yuyan Zhu
- Chuize Kong
-
Affiliations: Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China - Published online on: July 15, 2020 https://doi.org/10.3892/ol.2020.11872
- Article Number: 11
-
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
![]() |
Wang Y, He J, Liao M, Hu M, Li W, Ouyang H, Wang X, Ye T, Zhang Y and Ouyang L: An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. Eur J Med Chem. 161:48–77. 2019. View Article : Google Scholar : PubMed/NCBI | |
Jing H and Lin H: Sirtuins in epigenetic regulation. Chem Rev. 115:2350–2375. 2015. View Article : Google Scholar : PubMed/NCBI | |
Hirschey MD: Old enzymes, new tricks: Sirtuins are NAD(+)-dependent de-acylases. Cell Metab. 14:718–719. 2011. View Article : Google Scholar : PubMed/NCBI | |
Klar AJ, Fogel S and Macleod K: MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE. Genetics. 93:37–50. 1979.PubMed/NCBI | |
Michan S and Sinclair D: Sirtuins in mammals: Insights into their biological function. Biochem J. 404:1–13. 2007. View Article : Google Scholar : PubMed/NCBI | |
Frye RA: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 273:793–798. 2000. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Zhou Y, Wang F, Chen X, Wang C, Wang J, Liu T, Li Y and He B: SIRT4 is the last puzzle of mitochondrial sirtuins. Bioorg Med Chem. 26:3861–3865. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tanno M, Sakamoto J, Miura T, Shimamoto K and Horio Y: Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem. 282:6823–6832. 2007. View Article : Google Scholar : PubMed/NCBI | |
Liszt G, Ford E, Kurtev M and Guarente L: Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem. 280:21313–21320. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kumar S and Lombard DB: Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal. 22:1060–1077. 2015. View Article : Google Scholar : PubMed/NCBI | |
Michishita E, Park JY, Burneskis JM, Barrett JC and Horikawa I: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 16:4623–4635. 2005. View Article : Google Scholar : PubMed/NCBI | |
Mei Z, Zhang X, Yi J, Huang J, He J and Tao Y: Sirtuins in metabolism, DNA repair and cancer. J Exp Clin Cancer Res. 35:1822016. View Article : Google Scholar : PubMed/NCBI | |
Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R and Reinberg D: SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 20:1256–1261. 2006. View Article : Google Scholar : PubMed/NCBI | |
Jeong SM and Haigis MC: Sirtuins in cancer: A balancing act between genome stability and metabolism. Mol Cells. 38:750–758. 2015. View Article : Google Scholar : PubMed/NCBI | |
German NJ and Haigis MC: Sirtuins and the metabolic hurdles in cancer. Curr Biol. 25:R569–R583. 2015. View Article : Google Scholar : PubMed/NCBI | |
Grabowska W, Sikora E and Bielak-Zmijewska A: Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 18:447–476. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kupis W, Palyga J, Tomal E and Niewiadomska E: The role of sirtuins in cellular homeostasis. J Physiol Biochem. 72:371–380. 2016. View Article : Google Scholar : PubMed/NCBI | |
Frye RA: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun. 260:273–279. 1999. View Article : Google Scholar : PubMed/NCBI | |
North BJ, Marshall BL, Borra MT, Denu JM and Verdin E: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell. 11:437–444. 2003. View Article : Google Scholar : PubMed/NCBI | |
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, et al: SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126:941–954. 2006. View Article : Google Scholar : PubMed/NCBI | |
Kumar S and Lombard DB: For certain, SIRT4 activities! Trends Biochem Sci. 42:499–501. 2017. View Article : Google Scholar : PubMed/NCBI | |
Shi JX, Wang QJ, Li H and Huang Q: SIRT4 overexpression protects against diabetic nephropathy by inhibiting podocyte apoptosis. Exp Ther Med. 13:342–348. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kane AE and Sinclair DA: Sirtuins and NAD(+) in the development and treatment of metabolic and cardiovascular diseases. Circ Res. 123:868–885. 2018. View Article : Google Scholar : PubMed/NCBI | |
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, et al: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425:191–196. 2003. View Article : Google Scholar : PubMed/NCBI | |
McGuinness D, McGuinness DH, McCaul JA and Shiels PG: Sirtuins, bioageing, and cancer. J Aging Res. 2011:2357542011. View Article : Google Scholar : PubMed/NCBI | |
Onyango P, Celic I, McCaffery JM, Boeke JD and Feinberg AP: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci USA. 99:13653–13658. 2002. View Article : Google Scholar : PubMed/NCBI | |
Schwer B, North BJ, Frye RA, Ott M and Verdin E: The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol. 158:647–657. 2002. View Article : Google Scholar : PubMed/NCBI | |
Finnin MS, Donigian JR and Pavletich NP: Structure of the histone deacetylase SIRT2. Nat Struct Biol. 8:621–625. 2001. View Article : Google Scholar : PubMed/NCBI | |
Bellamacina CR: The nicotinamide dinucleotide binding motif: A comparison of nucleotide binding proteins. FASEB J. 10:1257–1269. 1996. View Article : Google Scholar : PubMed/NCBI | |
Sanders BD, Jackson B and Marmorstein R: Structural basis for sirtuin function: What we know and what we don't. Biochim Biophys Acta. 1804:1604–1616. 2010. View Article : Google Scholar : PubMed/NCBI | |
Moniot S, Weyand M and Steegborn C: Structures, substrates, and regulators of Mammalian sirtuins-opportunities and challenges for drug development. Front Pharmacol. 3:162012. View Article : Google Scholar : PubMed/NCBI | |
Yuan H and Marmorstein R: Structural basis for sirtuin activity and inhibition. J Biol Chem. 287:42428–42435. 2012. View Article : Google Scholar : PubMed/NCBI | |
Moniot S, Schutkowski M and Steegborn C: Crystal structure analysis of human Sirt2 and its ADP-ribose complex. J Struct Biol. 182:136–143. 2013. View Article : Google Scholar : PubMed/NCBI | |
Zhou Y, Zhang H, He B, Du J, Lin H, Cerione RA and Hao Q: The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem. 287:28307–28314. 2012. View Article : Google Scholar : PubMed/NCBI | |
Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek, et al: Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem. 284:24394–24405. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P and Verdin E: Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 282:33583–33592. 2007. View Article : Google Scholar : PubMed/NCBI | |
Pannek M, Simic Z, Fuszard M, Meleshin M, Rotili D, Mai A, Schutkowski M and Steegborn C: Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun. 8:15132017. View Article : Google Scholar : PubMed/NCBI | |
Kato Y, Kihara H, Fukui K and Kojima M: A ternary complex model of Sirtuin4-NAD+-Glutamate dehydrogenase. Comput Biol Chem. 74:94–104. 2018. View Article : Google Scholar : PubMed/NCBI | |
Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, et al: Investigating the sensitivity of NAD+-dependent sirtuin deacylation activities to NADH. J Biol Chem. 291:7128–7141. 2016. View Article : Google Scholar : PubMed/NCBI | |
Feldman JL, Dittenhafer-Reed KE, Kudo N, Thelen JN, Ito A, Yoshida M and Denu JM: Kinetic and structural basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation. Biochemistry. 54:3037–3050. 2015. View Article : Google Scholar : PubMed/NCBI | |
Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 12:931–947. 2013. View Article : Google Scholar : PubMed/NCBI | |
Fernandez-Marcos PJ and Serrano M: Sirt4: The glutamine gatekeeper. Cancer Cell. 23:427–428. 2013. View Article : Google Scholar : PubMed/NCBI | |
Altman BJ, Stine ZE and Dang CV: From Krebs to clinic: Glutamine metabolism to cancer therapy. Nat Rev Cancer. 16:7492016. View Article : Google Scholar : PubMed/NCBI | |
Argmann C and Auwerx J: Insulin secretion: SIRT4 gets in on the act. Cell. 126:837–839. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lang J: Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem. 259:3–17. 1999. View Article : Google Scholar : PubMed/NCBI | |
Ashcroft FM, Proks P, Smith PA, Ammala C, Bokvist K and Rorsman P: Stimulus-secretion coupling in pancreatic beta cells. J Cell Biochem. 55 (Suppl):S54–S65. 1994. View Article : Google Scholar | |
Glozak MA, Sengupta N, Zhang X and Seto E: Acetylation and deacetylation of non-histone proteins. Gene. 363:15–23. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sauve AA, Wolberger C, Schramm VL and Boeke JD: The biochemistry of sirtuins. Annu Rev Biochem. 75:435–465. 2006. View Article : Google Scholar : PubMed/NCBI | |
Feldman JL, Baeza J and Denu JM: Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. J Biol Chem. 288:31350–31356. 2013. View Article : Google Scholar : PubMed/NCBI | |
Nasrin N, Wu X, Fortier E, Feng Y, Bare' OC, Chen S, Ren X, Wu Z, Streeper RS and Bordone L: SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. J Biol Chem. 285:31995–32002. 2010. View Article : Google Scholar : PubMed/NCBI | |
Hardie DG: Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr. 93:891S–896. 2011. View Article : Google Scholar : PubMed/NCBI | |
Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, et al: SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 50:686–698. 2013. View Article : Google Scholar : PubMed/NCBI | |
Saggerson D: Malonyl-CoA, a key signaling molecule in mammalian cells. Annu Rev Nutr. 28:253–272. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B and Wahli W: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 103:1489–1498. 1999. View Article : Google Scholar : PubMed/NCBI | |
Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA and Haigis MC: SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Mol Cell Biol. 33:4552–4561. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ibdah JA, Paul H, Zhao Y, Binford S, Salleng K, Cline M, Matern D, Bennett MJ, Rinaldo P and Strauss AW: Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest. 107:1403–1409. 2001. View Article : Google Scholar : PubMed/NCBI | |
Guo L, Zhou SR, Wei XB, Liu Y, Chang XX, Liu Y, Ge X, Dou X, Huang HY, Qian SW, et al: Acetylation of mitochondrial trifunctional protein α-subunit enhances its stability to promote fatty acid oxidation and is decreased in nonalcoholic fatty liver disease. Mol Cell Biol. 36:2553–2567. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zhou ZH, McCarthy DB, O'Connor CM, Reed LJ and Stoops JK: The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes. Proc Natl Acad Sci USA. 98:14802–14807. 2001. View Article : Google Scholar : PubMed/NCBI | |
Mathias RA, Greco TM, Oberstein A, Budayeva HG, Chakrabarti R, Rowland EA, Kang Y, Shenk T and Cristea IM: Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell. 159:1615–1625. 2014. View Article : Google Scholar : PubMed/NCBI | |
MacDonald MJ, Fahien LA, Brown LJ, Hasan NM, Buss JD and Kendrick MA: Perspective: Emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion. Am J Physiol Endocrinol Metab. 288:E1–E15. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sener A and Malaisse WJ: L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature. 288:187–189. 1980. View Article : Google Scholar : PubMed/NCBI | |
Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, et al: SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion. Cell Metab. 25:838–855 e15. 2017. View Article : Google Scholar : PubMed/NCBI | |
Huynh FK, Hu X, Lin Z, Johnson JD and Hirschey MD: Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. J Inherit Metab Dis. 41:59–72. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zaganjor E, Vyas S and Haigis MC: SIRT4 is a regulator of insulin secretion. Cell Chem Biol. 24:656–658. 2017. View Article : Google Scholar : PubMed/NCBI | |
Klingenberg M: The ADP and ATP transport in mitochondria and its carrier. Biochim Biophys Acta. 1778:1978–2021. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E and Kolthur-Seetharam U: SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY). 5:835–849. 2013. View Article : Google Scholar : PubMed/NCBI | |
Warburg O, Wind F and Negelein E: The metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927. View Article : Google Scholar : PubMed/NCBI | |
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM and Locasale JW: Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol. 76:325–334. 2011. View Article : Google Scholar | |
Fuchs BC and Bode BP: Stressing out over survival: Glutamine as an apoptotic modulator. J Surg Res. 131:26–40. 2006. View Article : Google Scholar : PubMed/NCBI | |
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB and Thompson CB: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA. 105:18782–18787. 2008. View Article : Google Scholar : PubMed/NCBI | |
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S and Thompson CB: Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA. 104:19345–19350. 2007. View Article : Google Scholar : PubMed/NCBI | |
Daye D and Wellen KE: Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis. Semin Cell Dev Biol. 23:362–369. 2012. View Article : Google Scholar : PubMed/NCBI | |
Lukey MJ, Wilson KF and Cerione RA: Therapeutic strategies impacting cancer cell glutamine metabolism. Future Med Chem. 5:1685–1700. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yuan H, Su L and Chen WY: The emerging and diverse roles of sirtuins in cancer: A clinical perspective. Onco Targets Ther. 6:1399–1416. 2013.PubMed/NCBI | |
Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, et al: Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA. 98:13784–13789. 2001. View Article : Google Scholar : PubMed/NCBI | |
Blaveri E, Simko JP, Korkola JE, Brewer JL, Baehner F, Mehta K, Devries S, Koppie T, Pejavar S, Carroll P and Waldman FM: Bladder cancer outcome and subtype classification by gene expression. Clin Cancer Res. 11:4044–4055. 2005. View Article : Google Scholar : PubMed/NCBI | |
Choi YL, Tsukasaki K, O'Neill MC, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, et al: A genomic analysis of adult T-cell leukemia. Oncogene. 26:1245–1255. 2007. View Article : Google Scholar : PubMed/NCBI | |
Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, et al: SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 23:450–463. 2013. View Article : Google Scholar : PubMed/NCBI | |
Mahjabeen I and Kayani MA: Loss of mitochondrial tumor suppressor genes expression is associated with unfavorable clinical outcome in head and neck squamous cell carcinoma: Data from retrospective study. PLoS One. 11:e01469482016. View Article : Google Scholar : PubMed/NCBI | |
Wang YS, Du L, Liang X, Meng P, Bi L, Wang YL, Wang C and Tang B: Sirtuin 4 depletion promotes hepatocellular carcinoma tumorigenesis through regulating adenosine-monophosphate-activated protein kinase alpha/mammalian target of rapamycin axis in mice. Hepatology. 69:1614–1631. 2019. View Article : Google Scholar : PubMed/NCBI | |
Fu L, Dong Q, He J, Wang X, Xing J, Wang E, Qiu X and Li Q: SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK-Drp1 pathway. Oncogene. 36:2724–2736. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chen X, Lai X, Wu C, Tian Q, Lei T, Pan J and Huang G: Decreased SIRT4 protein levels in endometrioid adenocarcinoma tissues are associated with advanced AJCC stage. Cancer Biomark. 19:419–424. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Guo Y, Gao J and Yuan X: Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage. Cancer Manag Res. 10:5591–5603. 2018. View Article : Google Scholar : PubMed/NCBI | |
Sun H, Huang D, Liu G, Jian F, Zhu J and Zhang L: SIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion. Onco Targets Ther. 11:3959–3968. 2018. View Article : Google Scholar : PubMed/NCBI | |
Huang G, Cui F, Yu F, Lu H, Zhang M, Tang H and Peng Z: Sirtuin-4 (SIRT4) is downregulated and associated with some clinicopathological features in gastric adenocarcinoma. Biomed Pharmacother. 72:135–139. 2015. View Article : Google Scholar : PubMed/NCBI | |
Shen X, Li P, Xu Y, Chen X, Sun H, Zhao Y, Liu M and Zhang W: Association of sirtuins with clinicopathological parameters and overall survival in gastric cancer. Oncotarget. 8:74359–74370. 2017. View Article : Google Scholar : PubMed/NCBI | |
Hu Y, Lin J, Lin Y, Chen X, Zhu G and Huang G: Overexpression of SIRT4 inhibits the proliferation of gastric cancer cells through cell cycle arrest. Oncol Lett. 17:2171–2176. 2019.PubMed/NCBI | |
Miyo M, Yamamoto H, Konno M, Colvin H, Nishida N, Koseki J, Kawamoto K, Ogawa H, Hamabe A, Uemura M, et al: Tumour-suppressive function of SIRT4 in human colorectal cancer. Br J Cancer. 113:492–499. 2015. View Article : Google Scholar : PubMed/NCBI | |
Huang G, Cheng J, Yu F, Liu X, Yuan C, Liu C, Chen X and Peng Z: Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer. Oncol Rep. 35:2801–2810. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zhu Y, Wang G, Li X, Wang T, Weng M and Zhang Y: Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells. Oncol Lett. 16:1675–1681. 2018.PubMed/NCBI | |
Shi Q, Liu T, Zhang X, Geng J, He X, Nu M and Pang D: Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer. Oncol Lett. 12:2606–2612. 2016. View Article : Google Scholar : PubMed/NCBI | |
Nakahara Y, Yamasaki M, Sawada G, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mimori K, et al: Downregulation of SIRT4 expression is associated with poor prognosis in esophageal squamous cell carcinoma. Oncology. 90:347–355. 2016. View Article : Google Scholar : PubMed/NCBI | |
Jeong SM, Lee A, Lee J and Haigis MC: SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. J Biol Chem. 289:4135–4144. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chen Z, Lin J, Feng S, Chen X, Huang H, Wang C, Yu Y, He Y, Han S, Zheng L and Huang G: SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism. Onco Targets Ther. 12:2397–2408. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X and Xu X: UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Cancer Lett. 452:226–236. 2019. View Article : Google Scholar : PubMed/NCBI | |
Negrini S, Gorgoulis VG and Halazonetis TD: Genomic instability-an evolving hallmark of cancer. Nat Rev Mol Cell Biol. 11:220–228. 2010. View Article : Google Scholar : PubMed/NCBI | |
Colombo SL, Palacios-Callender M, Frakich N, Carcamo S, Kovacs I, Tudzarova S and Moncada S: Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Proc Natl Acad Sci USA. 108:21069–21074. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Zhou H, Wang Y, Cui G and Di LJ: CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Dis. 6:e16202015. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Li JJ, Guo LY, Li P, Zhao Z, Zhou H and Di LJ: Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4. Oncogenesis. 7:262018. View Article : Google Scholar : PubMed/NCBI | |
Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, et al: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153:840–854. 2013. View Article : Google Scholar : PubMed/NCBI | |
van de Ven RAH, Santos D and Haigis MC: Mitochondrial Sirtuins and molecular mechanisms of aging. Trends Mol Med. 23:320–331. 2017. View Article : Google Scholar | |
Xing J, Li J, Fu L, Gai J, Guan J and Li Q: SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway. Cancer Med. 8:7086–7097. 2019. View Article : Google Scholar : PubMed/NCBI | |
Jeong SM, Hwang S and Seong RH: SIRT4 regulates cancer cell survival and growth after stress. Biochem Biophys Res Commun. 470:251–256. 2016. View Article : Google Scholar : PubMed/NCBI | |
Liu M, Wang Z, Ren M, Yang X, Liu B, Qi H, Yu M, Song S, Chen S, Liu L, et al: SIRT4 regulates PTEN stability through IDE in response to cellular stresses. FASEB J. 33:5535–5547. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P and Pavletich NP: Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association. Cell. 99:323–334. 1999. View Article : Google Scholar : PubMed/NCBI | |
Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP and Hanafusa H: Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res. 60:7033–7038. 2000.PubMed/NCBI | |
Mizushima N and Klionsky DJ: Protein turnover via autophagy: Implications for metabolism. Annu Rev Nutr. 27:19–40. 2007. View Article : Google Scholar : PubMed/NCBI | |
Luo YX, Tang X, An XZ, Xie XM, Chen XF, Zhao X, Hao DL, Chen HZ and Liu DP: SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J. 38:1389–1398. 2017.PubMed/NCBI | |
Xiao Y, Zhang X, Fan S, Cui G and Shen Z: MicroRNA-497 inhibits cardiac hypertrophy by targeting Sirt4. PLoS One. 11:e01680782016. View Article : Google Scholar : PubMed/NCBI | |
Zeng G, Liu H and Wang H: Amelioration of myocardial ischemia-reperfusion injury by SIRT4 involves mitochondrial protection and reduced apoptosis. Biochem Biophys Res Commun. 502:15–21. 2018. View Article : Google Scholar : PubMed/NCBI | |
Shih J, Liu L, Mason A, Higashimori H and Donmez G: Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid. J Neurochem. 131:573–581. 2014. View Article : Google Scholar : PubMed/NCBI | |
Komlos D, Mann KD, Zhuo Y, Ricupero CL, Hart RP, Liu AY and Firestein BL: Glutamate dehydrogenase 1 and SIRT4 regulate glial development. Glia. 61:394–408. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ramatchandirin B, Sadasivam M, Kannan A and Prahalathan C: Sirtuin 4 regulates lipopolysaccharide mediated leydig cell dysfunction. J Cell Biochem. 117:904–916. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zeng J, Jiang M, Wu X, Diao F, Qiu D, Hou X, Wang H, Li L, Li C, Ge J, et al: SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation. Aging Cell. 17:e127892018. View Article : Google Scholar : PubMed/NCBI | |
Nunnari J and Suomalainen A: Mitochondria: In sickness and in health. Cell. 148:1145–1159. 2012. View Article : Google Scholar : PubMed/NCBI | |
Han Y, Zhou S, Coetzee S and Chen A: SIRT4 and its roles in energy and redox metabolism in health, disease and during exercise. Front Physiol. 10:10062019. View Article : Google Scholar : PubMed/NCBI | |
Min Z, Gao J and Yu Y: The roles of mitochondrial SIRT4 in cellular metabolism. Front Endocrinol (Lausanne). 9:7832019. View Article : Google Scholar : PubMed/NCBI | |
Li S and Zheng W: Mammalian Sirtuins SIRT4 and SIRT7. Prog Mol Biol Transl Sci. 154:147–168. 2018. View Article : Google Scholar : PubMed/NCBI | |
Song R, Xu W, Chen Y, Li Z, Zeng Y and Fu Y: The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes. Eur J Histochem. 55:e102011. View Article : Google Scholar : PubMed/NCBI | |
Kim EA, Yang SJ, Choi SY, Lee WJ and Cho SW: Inhibition of glutamate dehydrogenase and insulin secretion by KHG26377 does not involve ADP-ribosylation by SIRT4 or deacetylation by SIRT3. BMB Rep. 45:458–463. 2012. View Article : Google Scholar : PubMed/NCBI | |
Lappas M: Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm. 2012:5975142012. View Article : Google Scholar : PubMed/NCBI | |
Sebastian C, Satterstrom FK, Haigis MC and Mostoslavsky R: From sirtuin biology to human diseases: An update. J Biol Chem. 287:42444–42452. 2012. View Article : Google Scholar : PubMed/NCBI |