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GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer

  • Authors:
    • Xiang-Rui Qiao
    • Xinwei Zhang
    • Lijun Mu
    • Juanhua Tian
    • Yuefeng Du

  • View Affiliations

  • Published online on: August 7, 2020     https://doi.org/10.3892/ol.2020.11960
  • Article Number: 99

  • Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The development of prostate cancer is complicated and involves a number of tumor‑associated gene expression level abnormalities. Gene chip technology is a high‑throughput method that can detect gene expression levels in different tissues and cells on a large scale. In the present study, gene chip technology was used to screen differentially expressed genes in PC‑3 human prostate cancer cells following GRB‑associated binding protein 2 (GAB2) gene knockdown, and the corresponding biological information was analyzed to investigate the role of GAB2 in prostate cancer. The PC‑3 human prostate cancer cell GAB2 gene was knocked out and gene chip hybridization and bioinformatics methods were used to analyze the classical pathway and predict upstream regulatory molecules, disease and function associations and genetic interaction networks. According to the screening conditions |fold change|>1 and P<0.05, 1,242 differential genes were screened; 665 genes were upregulated, and 577 genes were downregulated. Ingenuity Pathway Analysis software demonstrated that GAB2 regulates pathways, such as the superpathway of cholesterol biosynthesis and p53 signaling in cells, and serves a role in diseases and functions such as ‘non‑melanoma solid tumors’, ‘viral infections’ and ‘morbidity or mortality’. In the occurrence and development of prostate cancer, factors such as the activation of genes involved in the proliferative cycle, abnormalities in metabolism‑associated enzyme gene activities and viral infection play key roles. The present study provides novel research directions and therapeutic targets for prostate cancer.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qiao X, Zhang X, Mu L, Tian J and Du Y: GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer. Oncol Lett 20: 99, 2020.
APA
Qiao, X., Zhang, X., Mu, L., Tian, J., & Du, Y. (2020). GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer. Oncology Letters, 20, 99. https://doi.org/10.3892/ol.2020.11960
MLA
Qiao, X., Zhang, X., Mu, L., Tian, J., Du, Y."GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer". Oncology Letters 20.4 (2020): 99.
Chicago
Qiao, X., Zhang, X., Mu, L., Tian, J., Du, Y."GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer". Oncology Letters 20, no. 4 (2020): 99. https://doi.org/10.3892/ol.2020.11960