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Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer

  • Authors:
    • Yang Bai
    • Haiyan Wu
    • Bin Han
    • Ke Xu
    • Yuanqi Liu
    • Yin  Liu
    • Shikun Miao
    • Yuanyuan Zhang
    • Liming Zhou

  • View Affiliations

  • Published online on: August 19, 2020     https://doi.org/10.3892/ol.2020.11987
  • Article Number: 124

  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Accumulating evidence has demonstrated that long non‑coding RNAs (lncRNAs) are frequently overexpressed in colorectal cancer (CRC). However, few related lncRNA signatures have been established for predicting CRC metastasis. The purpose of the present study was to identify lncRNAs that serve key roles in the metastasis of human CRC, and their potential downstream targets. A total of 31 human CRC biopsy samples were collected, and the expression of long intergenic non‑protein coding RNA‑467 (linc00467) and its association with clinical characteristics were evaluated. Consequently, linc00467 was revealed to be overexpressed in human CRC tissues, and its expression was significantly associated with metastasis and Tumor‑Node‑Metastasis stage. In HT29 and HCT116 cells, linc00467‑knockout was revealed to decrease cellular proliferation and increase apoptosis (P<0.05). Finally, the downstream target of linc00467 in CRC promotion was predicted using bioinformatics analysis. The results demonstrated that linc00467 targets and regulates the expression of microRNA (miR)‑451a, promoting carcinogenesis and metastasis in CRC. In conclusion, the results of the present study indicate that increased linc00467 expression promotes metastasis by targeting miR‑451a, which ultimately increases cellular proliferation and inhibits apoptosis in human CRC cells.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bai Y, Wu H, Han B, Xu K, Liu Y, Liu Y, Miao S, Zhang Y and Zhou L: Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer. Oncol Lett 20: 124, 2020.
APA
Bai, Y., Wu, H., Han, B., Xu, K., Liu, Y., Liu, Y. ... Zhou, L. (2020). Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer. Oncology Letters, 20, 124. https://doi.org/10.3892/ol.2020.11987
MLA
Bai, Y., Wu, H., Han, B., Xu, K., Liu, Y., Liu, Y., Miao, S., Zhang, Y., Zhou, L."Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer". Oncology Letters 20.5 (2020): 124.
Chicago
Bai, Y., Wu, H., Han, B., Xu, K., Liu, Y., Liu, Y., Miao, S., Zhang, Y., Zhou, L."Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer". Oncology Letters 20, no. 5 (2020): 124. https://doi.org/10.3892/ol.2020.11987