Open Access

Agaricus blazei extract (FA‑2‑b‑β) induces apoptosis in chronic myeloid leukemia cells

  • Authors:
    • Yanqing Sun
    • Mingxia Cheng
    • Li Dong
    • Kehu Yang
    • Zhiyuan Ma
    • Shangrui Yu
    • Peijing Yan
    • Kuntian Bai
    • Xiaolong Zhu
    • Qike Zhang
  • View Affiliations

  • Published online on: September 21, 2020     https://doi.org/10.3892/ol.2020.12133
  • Article Number: 270
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Agaricus blazei Murill (AbM) is a mushroom belonging to the Basidiomycetes family, which is believed to have antitumor and antioxidative activities. Proteoglycans and ergosterol are considered the key compounds of AbM for antitumor properties and so are used in complementary and alternative medicine as an anticancer drug. AbM is used to avoid serious side effects that would inevitably affect patients. Currently, the efficacy of AbM against chronic myeloid leukemia (CML) has not been established. The present study aimed to investigate the antitumor activities of the acidic RNA protein complex, FA‑2‑b‑β, extracted from wild edible AbM. The CML K562 cells or primary CML bone marrow (BM) cells were treated with FA‑2‑b‑β at different concentrations and time points. CML cell line proliferation and apoptosis were determined using the CCK‑8 assay or Annexin V/propidium iodide (PI) labeling, RT‑qPCR and western blotting was performed to determine the involvement of the Wnt/β‑catenin‑associated apoptotic pathway. The results of the present study demonstrated that FA‑2‑b‑β has a high anti‑proliferative potency and strong pro‑apoptotic effects. Thus, daily intake of mushrooms containing FA‑2‑b‑β may be an adequate source as an alternative medicine in the management of CML, and may provide useful information for the development of a novel therapeutic target in this area.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Sun Y, Cheng M, Dong L, Yang K, Ma Z, Yu S, Yan P, Bai K, Zhu X, Zhang Q, Zhang Q, et al: <em>Agaricus blazei</em> extract (FA‑2‑b‑&beta;) induces apoptosis in chronic myeloid leukemia cells. Oncol Lett 20: 270, 2020.
APA
Sun, Y., Cheng, M., Dong, L., Yang, K., Ma, Z., Yu, S. ... Zhang, Q. (2020). <em>Agaricus blazei</em> extract (FA‑2‑b‑&beta;) induces apoptosis in chronic myeloid leukemia cells. Oncology Letters, 20, 270. https://doi.org/10.3892/ol.2020.12133
MLA
Sun, Y., Cheng, M., Dong, L., Yang, K., Ma, Z., Yu, S., Yan, P., Bai, K., Zhu, X., Zhang, Q."<em>Agaricus blazei</em> extract (FA‑2‑b‑&beta;) induces apoptosis in chronic myeloid leukemia cells". Oncology Letters 20.5 (2020): 270.
Chicago
Sun, Y., Cheng, M., Dong, L., Yang, K., Ma, Z., Yu, S., Yan, P., Bai, K., Zhu, X., Zhang, Q."<em>Agaricus blazei</em> extract (FA‑2‑b‑&beta;) induces apoptosis in chronic myeloid leukemia cells". Oncology Letters 20, no. 5 (2020): 270. https://doi.org/10.3892/ol.2020.12133