Open Access

T lymphocytes related biomarkers for predicting immunotherapy efficacy in non‑small cell lung cancer (Review)

  • Authors:
    • Xiaoying Wei
    • Ling Gu
    • Wei Heng
  • View Affiliations

  • Published online on: December 6, 2020     https://doi.org/10.3892/ol.2020.12350
  • Article Number: 89
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The immune environment is a determinant of whether patients with cancer can benefit from immunotherapy. Immune checkpoint inhibitors (ICIs) have improved the prognosis of patients with different types of malignancies and have initiated a transformation in tumor therapy. However, some patients cannot achieve a long‑term response and several patients even have no response to ICIs therapy. Thus, potential biomarkers that can effectively predict the efficacy of ICIs are essential for their clinical application and for the selection of patients. The accuracy of well‑known biomarkers, such as expression of programmed cell death ligand 1 and tumor mutational burden, remains controversial. One of the critical factors for immune responses in the tumor microenvironment is tumor antigen‑specific T cell. The density and distribution of tumor‑infiltrating lymphocytes, T cells activation and T lymphocytes phenotypes in peripheral blood and serum cytokines have been observed in different types of solid cancer. Although the association with immunotherapy prognosis is in dispute, the prospect of T cell‑related biomarkers is encouraged. The present review discusses whether these factors are associated with clinical outcomes of patients with non‑small cell lung cancer. The association between several serum cytokines and ICIs therapy efficacy is also discussed.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wei X, Gu L and Heng W: T lymphocytes related biomarkers for predicting immunotherapy efficacy in non‑small cell lung cancer (Review). Oncol Lett 21: 89, 2021.
APA
Wei, X., Gu, L., & Heng, W. (2021). T lymphocytes related biomarkers for predicting immunotherapy efficacy in non‑small cell lung cancer (Review). Oncology Letters, 21, 89. https://doi.org/10.3892/ol.2020.12350
MLA
Wei, X., Gu, L., Heng, W."T lymphocytes related biomarkers for predicting immunotherapy efficacy in non‑small cell lung cancer (Review)". Oncology Letters 21.2 (2021): 89.
Chicago
Wei, X., Gu, L., Heng, W."T lymphocytes related biomarkers for predicting immunotherapy efficacy in non‑small cell lung cancer (Review)". Oncology Letters 21, no. 2 (2021): 89. https://doi.org/10.3892/ol.2020.12350