Open Access

Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer

  • Authors:
    • Kangrong Zhao
    • Yanlin Li
    • Tiantian Han
    • Aiqin Sun
    • Wenxuan Bian
    • Mingyue Li
    • Qiong Lin
    • Genbao Shao
  • View Affiliations

  • Published online on: December 8, 2020     https://doi.org/10.3892/ol.2020.12363
  • Article Number: 102
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lysine‑specific demethylase 1 (LSD1) is a nuclear protein and the first histone demethylase to be identified. LSD1 is an evolutionarily conserved member of the FAD‑dependent amine oxidase family and serves an important role in controlling gene expression. LSD1 has been implicated in the tumorigenesis and progression of several types of human cancer; however, to the best of our knowledge, the expression levels and clinical significance of LSD1 in triple‑negative breast cancer (TNBC) and non‑triple‑negative breast cancer (NTNBC) have not been investigated in detail. Therefore, the present study aimed to compare the expression levels of LSD1 in TNBC and NTNBC to determine the prognostic significance of LSD1 in breast cancer. Previous studies have suggested that LSD1 may be involved in the carcinogenesis and progression of breast cancer; however, the findings of the present study indicated that LSD1 may not be a suitable molecular treatment target and auxiliary diagnostic indicator for TNBC and NTNBC.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao K, Li Y, Han T, Sun A, Bian W, Li M, Lin Q and Shao G: Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer. Oncol Lett 21: 102, 2021
APA
Zhao, K., Li, Y., Han, T., Sun, A., Bian, W., Li, M. ... Shao, G. (2021). Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer. Oncology Letters, 21, 102. https://doi.org/10.3892/ol.2020.12363
MLA
Zhao, K., Li, Y., Han, T., Sun, A., Bian, W., Li, M., Lin, Q., Shao, G."Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer". Oncology Letters 21.2 (2021): 102.
Chicago
Zhao, K., Li, Y., Han, T., Sun, A., Bian, W., Li, M., Lin, Q., Shao, G."Comparison of the expression levels of lysine‑specific demethylase 1 and survival outcomes between triple‑negative and non‑triple‑negative breast cancer". Oncology Letters 21, no. 2 (2021): 102. https://doi.org/10.3892/ol.2020.12363