Open Access

Novel insights into the role of Clostridium novyi‑NT related combination bacteriolytic therapy in solid tumors (Review)

  • Authors:
    • Xu Feng
    • Pan He
    • Chen Zeng
    • Ye-Han Li
    • Sushant K. Das
    • Bing Li
    • Han-Feng Yang
    • Yong Du
  • View Affiliations

  • Published online on: December 11, 2020     https://doi.org/10.3892/ol.2020.12371
  • Article Number: 110
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Several solid tumors (for example leiomyosarcoma, melanoma and hepatocellular carcinoma) possess areas of hypoxia, which underlies one of the primary reasons of failure of conventional anticancer therapies. The areas of poor vascularization are insensitive to radiotherapy and chemotherapeutic drugs. Conversely, the hypoxic regions of tumors provide an ideal environment for anaerobic bacteria. The attenuated anaerobic bacterium, Clostridium novyi‑NT (C. novyi‑NT), is highly sensitive to oxygen and can target the destruction of hypoxic and necrotic areas of tumors, inducing oncolysis and characteristics indicative of an immune response. Theoretically, chemotherapy, radiotherapy and immunotherapy combined with bacterial therapy can be used as a novel means of treating solid tumors, promoting tumor regression and inhibiting metastasis formation with a notable beneficial effect. The present review discusses the molecular mechanisms of combined bacteriolytic therapy, predominantly focusing on C. novyi‑NT, and summarizes the findings of previous studies on experimental animal models, including its efficacy and safety via different drug delivery routes. This strategy has great potential to overcome the limitations of conventional cancer therapy, resulting in improved treatments, and thus potentially improved outcomes for patients.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Feng X, He P, Zeng C, Li Y, Das SK, Li B, Yang H and Du Y: Novel insights into the role of Clostridium novyi‑NT related combination bacteriolytic therapy in solid tumors (Review). Oncol Lett 21: 110, 2021.
APA
Feng, X., He, P., Zeng, C., Li, Y., Das, S.K., Li, B. ... Du, Y. (2021). Novel insights into the role of Clostridium novyi‑NT related combination bacteriolytic therapy in solid tumors (Review). Oncology Letters, 21, 110. https://doi.org/10.3892/ol.2020.12371
MLA
Feng, X., He, P., Zeng, C., Li, Y., Das, S. K., Li, B., Yang, H., Du, Y."Novel insights into the role of Clostridium novyi‑NT related combination bacteriolytic therapy in solid tumors (Review)". Oncology Letters 21.2 (2021): 110.
Chicago
Feng, X., He, P., Zeng, C., Li, Y., Das, S. K., Li, B., Yang, H., Du, Y."Novel insights into the role of Clostridium novyi‑NT related combination bacteriolytic therapy in solid tumors (Review)". Oncology Letters 21, no. 2 (2021): 110. https://doi.org/10.3892/ol.2020.12371