Open Access

Association between B‑Myb proto‑oncogene and the development of malignant tumors (Review)

  • Authors:
    • Yuelei Jin
    • Gangqiao Qi
    • Guang Chen
    • Chen Wang
    • Xiaoyan Fan
  • View Affiliations

  • Published online on: January 4, 2021     https://doi.org/10.3892/ol.2021.12427
  • Article Number: 166
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

B‑Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B‑Myb promotes tumor formation and development. B‑Myb is a proto‑oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tumorigenesis and aging. In addition, B‑Myb is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development. B‑Myb expression is also associated with the prognosis of patients with malignant tumors. Both microRNAs and E2F family of transcription factors (E2Fs) contribute to the function of B‑Myb. The present review highlights the association between B‑Myb and malignant tumors, and offers a theoretical reference for the diagnosis and treatment of malignant tumors.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Jin Y, Qi G, Chen G, Wang C and Fan X: Association between B‑<em>Myb</em> proto‑oncogene and the development of malignant tumors (Review). Oncol Lett 21: 166, 2021.
APA
Jin, Y., Qi, G., Chen, G., Wang, C., & Fan, X. (2021). Association between B‑<em>Myb</em> proto‑oncogene and the development of malignant tumors (Review). Oncology Letters, 21, 166. https://doi.org/10.3892/ol.2021.12427
MLA
Jin, Y., Qi, G., Chen, G., Wang, C., Fan, X."Association between B‑<em>Myb</em> proto‑oncogene and the development of malignant tumors (Review)". Oncology Letters 21.2 (2021): 166.
Chicago
Jin, Y., Qi, G., Chen, G., Wang, C., Fan, X."Association between B‑<em>Myb</em> proto‑oncogene and the development of malignant tumors (Review)". Oncology Letters 21, no. 2 (2021): 166. https://doi.org/10.3892/ol.2021.12427