Open Access

Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma

  • Authors:
    • Xing Zhong
    • Zhiliang Liu
    • Qingfeng Luo
    • Jingao Li
    • Weiwei Zhang
    • Yuerong Shuang
  • View Affiliations

  • Published online on: February 2, 2021     https://doi.org/10.3892/ol.2021.12506
  • Article Number: 245
  • Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diffuse large B‑cell lymphoma (DLBCL) is the most common and heterogeneous lymphoid malignancy. The subtype with MYC and BCL‑2 double‑expressor lymphoma (DEL) was defined by its aggressive nature and poor survival outcome. Therefore, the development of effective therapies for the DEL subtype is imperative. Fatty acid synthase (FASN) activity is associated with altered lipid metabolism and aberrant protein translation in DLBCL. However, the inter‑regulation of these key processes is not fully determined in DEL. In the present study, the clinical and biological impact of FASN was investigated in the DEL subtype. Initially, FASN expression levels were analyzed from a patient cohort and the data indicated that the highest FASN expression was noted in DEL tissues compared with that noted in the DLBCL and reactive lymphoid hyperplasia tissues. Patients with DEL with combined high‑FASN expression indicated poorer EFS outcomes than the rest of the patients. In vitro data indicated that FASN was overexpressed in SU‑DHL‑2 and U2932 cells. Silencing FASN decreased cell growth and promoted cell apoptosis by modulating the pERK/BCL‑2 signaling pathway. In conclusion, the present study indicated that FASN was overexpressed in DEL and that its expression was associated with poor survival outcomes. Furthermore, the data demonstrated that FASN regulated the biological function via the pERK/BCL‑2 signaling pathway. FASN serves a critical role in the progression of DEL and its expression may be associated with the development to a more aggressive phenotype of DLBCL. Therefore, it may be considered a potential therapeutic target for DLBCL.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhong X, Liu Z, Luo Q, Li J, Zhang W and Shuang Y: Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma. Oncol Lett 21: 245, 2021.
APA
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., & Shuang, Y. (2021). Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma. Oncology Letters, 21, 245. https://doi.org/10.3892/ol.2021.12506
MLA
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., Shuang, Y."Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma". Oncology Letters 21.4 (2021): 245.
Chicago
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., Shuang, Y."Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma". Oncology Letters 21, no. 4 (2021): 245. https://doi.org/10.3892/ol.2021.12506