Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma

Zupancic,Mark; Haeggblom,Linnea; Landin,David; Marklund,Linda; Dalianis,Tina; Näsman,Anders

doi:10.3892/ol.2021.12538

Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma

Authors:
- Mark Zupancic
- Linnea Haeggblom
- David Landin
- Linda Marklund
- Tina Dalianis
- Anders Näsman
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Affiliations: Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden, Division of Ear, Nose and Throat Diseases, Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, 171 64 Stockholm, Sweden
Published online on: February 10, 2021 https://doi.org/10.3892/ol.2021.12538
Article Number: 277
Copyright: © Zupancic et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Patients with human papillomavirus-positive (HPV+) base of tongue squamous cell carcinomas (BOTSCC) have an improved survival compared with patients with HPV-negative BOTSCC and it has been suggested that treatment should be tailored. Before individualized treatment can be introduced, additional prognostic markers are required. A prognostic role of psoriasin has previously been demonstrated outside BOTSCC. Therefore, the present study aimed to examine psoriasin in BOTSCC, with focus on HPV+ BOTSCC, in relation to prognosis. A total of 72 BOTSCC samples were stained for psoriasin by immunohistochemistry, and the association between expression and clinical outcomes was analyzed. Patients with low psoriasin expression exhibited significantly improved overall survival (OS; P=0.001) and disease-free survival (DFS; P=0.007), which also was observed in patients with HPV+ BOTSCC (OS, P<0.001; DFS, P=0.02). Furthermore, psoriasin was a significant prognostic factor in univariable and multivariable analyses. In conclusion, psoriasin could be used as a prognostic marker in HPV+ BOTSCC.

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1	Näsman A, Du J and Dalianis T: A global epidemic increase of an HPV-induced tonsil and tongue base cancer - potential benefit from a pan-gender use of HPV vaccine. J Intern Med. 287:134–152. 2020. View Article : Google Scholar : PubMed/NCBI
2	Haeggblom L, Ramqvist T, Tommasino M, Dalianis T and Näsman A: Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years. Papillomavirus Res. 4:1–11. 2017. View Article : Google Scholar : PubMed/NCBI
3	Gelwan E, Malm IJ, Khararjian A, Fakhry C, Bishop JA and Westra WH: Nonuniform distribution of high-risk human papillomavirus in squamous cell carcinomas of the oropharynx: rethinking the anatomic boundaries of oral and oropharyngeal carcinoma from an oncologic HPV perspective. Am J Surg Pathol. 41:1722–1728. 2017. View Article : Google Scholar : PubMed/NCBI
4	Ljøkjel B, Lybak S, Haave H, Olofsson J, Vintermyr OK and Aarstad HJ: The impact of HPV infection on survival in a geographically defined cohort of oropharynx squamous cell carcinoma (OPSCC) patients in whom surgical treatment has been one main treatment. Acta Otolaryngol. 134:636–645. 2014. View Article : Google Scholar : PubMed/NCBI
5	Marklund L, Näsman A, Ramqvist T, Dalianis T, Munck-Wikland E and Hammarstedt L: Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer. Cancer Med. 1:82–88. 2012. View Article : Google Scholar : PubMed/NCBI
6	Tham T, Wotman M, Roche A, Kraus D and Costantino P: The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 40:567–572. 2019. View Article : Google Scholar : PubMed/NCBI
7	Marklund L, Holzhauser S, de Flon C, Zupancic M, Landin D, Kolev A, Haeggblom L, Munck-Wikland E, Hammarstedt-Nordenvall L, Dalianis T, et al: Survival of patients with oropharyngeal squamous cell carcinomas (OPSCC) in relation to TNM 8 - Risk of incorrect downstaging of HPV-mediated non-tonsillar, non-base of tongue carcinomas. Eur J Cancer. 139:192–200. 2020. View Article : Google Scholar : PubMed/NCBI
8	Näsman A, Bersani C, Lindquist D, Du J, Ramqvist T and Dalianis T: Human papillomavirus and potentially relevant biomarkers in tonsillar and base of tongue squamous cell carcinoma. Anticancer Res. 37:5319–5328. 2017.PubMed/NCBI
9	Ye L, Sun PH, Martin TA, Sanders AJ, Mason MD and Jiang WG: Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells. Urol Oncol. 31:1576–1583. 2013. View Article : Google Scholar : PubMed/NCBI
10	Liu J, Zhao Z, Sun Z, Liu C, Cheng X, Ruge F, Yang Y, Jiang WG and Ye L: Increased expression of psoriasin is correlated with poor prognosis of bladder transitional cell carcinoma by promoting invasion and proliferation. Oncol Rep. 43:562–570. 2020.PubMed/NCBI
11	Hattinger E, Zwicker S, Ruzicka T, Yuspa SH and Wolf R: Opposing functions of psoriasin (S100A7) and koebnerisin (S100A15) in epithelial carcinogenesis. Curr Opin Pharmacol. 13:588–594. 2013. View Article : Google Scholar : PubMed/NCBI
12	Liu Y, Bunston C, Hodson N, Resaul J, Sun PH, Cai S, Chen G, Gu Y, Satherley LK, Bosanquet DC, et al: Psoriasin promotes invasion, aggregation and survival of pancreatic cancer cells; association with disease progression. Int J Oncol. 50:1491–1500. 2017. View Article : Google Scholar : PubMed/NCBI
13	Al-Haddad S, Zhang Z, Leygue E, Snell L, Huang A, Niu Y, Hiller-Hitchcock T, Hole K, Murphy LC and Watson PH: Psoriasin (S100A7) expression and invasive breast cancer. Am J Pathol. 155:2057–2066. 1999. View Article : Google Scholar : PubMed/NCBI
14	Emberley ED, Murphy LC and Watson PH: S100A7 and the progression of breast cancer. Breast Cancer Res. 6:153–159. 2004. View Article : Google Scholar : PubMed/NCBI
15	Tripathi SC, Matta A, Kaur J, Grigull J, Chauhan SS, Thakar A, Shukla NK, Duggal R, DattaGupta S, Ralhan R, et al: Nuclear S100A7 is associated with poor prognosis in head and neck cancer. PLoS One. 5:e119392010. View Article : Google Scholar : PubMed/NCBI
16	Attner P, Du J, Näsman A, Hammarstedt L, Ramqvist T, Lindholm J, Marklund L, Dalianis T and Munck-Wikland E: The role of human papillomavirus in the increased incidence of base of tongue cancer. Int J Cancer. 126:2879–2884. 2010.PubMed/NCBI
17	Näsman A, Andersson E, Marklund L, Tertipis N, Hammarstedt-Nordenvall L, Attner P, Nyberg T, Masucci GV, Munck-Wikland E, Ramqvist T, et al: HLA class I and II expression in oropharyngeal squamous cell carcinoma in relation to tumor HPV status and clinical outcome. PLoS One. 8:e770252013. View Article : Google Scholar : PubMed/NCBI
18	Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 363:24–35. 2010. View Article : Google Scholar : PubMed/NCBI
19	Tertipis N, Hammar U, Näsman A, Vlastos A, Nordfors C, Grün N, Ährlund-Richter A, Sivars L, Haeggblom L, Marklund L, et al: A model for predicting clinical outcome in patients with human papillomavirus-positive tonsillar and base of tongue cancer. Eur J Cancer. 51:1580–1587. 2015. View Article : Google Scholar : PubMed/NCBI
20	Mayama A, Takagi K, Suzuki H, Sato A, Onodera Y, Miki Y, Sakurai M, Watanabe T, Sakamoto K, Yoshida R, et al: OLFM4, LY6D and S100A7 as potent markers for distant metastasis in estrogen receptor-positive breast carcinoma. Cancer Sci. 109:3350–3359. 2018. View Article : Google Scholar : PubMed/NCBI
21	Dey KK, Bharti R, Dey G, Pal I, Rajesh Y, Chavan S, Das S, Das CK, Jena BC, Halder P, et al: S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway. Cancer Gene Ther. 23:382–391. 2016. View Article : Google Scholar : PubMed/NCBI
22	Tiveron RC, de Freitas LC, Figueiredo DL, Serafini LN, Mamede RC and Zago MA: Expression of calcium binding protein S100 A7 (psoriasin) in laryngeal carcinoma. Rev Bras Otorrinolaringol (Engl Ed). 78:59–65. 2012.
23	Alowami S, Qing G, Emberley E, Snell L and Watson PH: Psoriasin (S100A7) expression is altered during skin tumorigenesis. BMC Dermatol. 3:12003. View Article : Google Scholar : PubMed/NCBI
24	Haeggblom L, Ährlund-Richter A, Mirzaie L, Farrajota Neves da Silva P, Ursu RG, Ramqvist T and Näsman A: Differences in gene expression between high-grade dysplasia and invasive HPV+ and HPV- tonsillar and base of tongue cancer. Cancer Med. 8:6221–6232. 2019. View Article : Google Scholar : PubMed/NCBI