Deciphering the structure, function, expression and regulation of aquaporin‑5 in cancer evolution (Review)
- Authors:
- Liping Wang
- Da Huo
- Haiyan Zhu
- Qian Xu
- Chengpeng Gao
- Wenfeng Chen
- Yixiang Zhang
-
Affiliations: Department of Oncology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Respiratory, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Science and Education, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China - Published online on: February 21, 2021 https://doi.org/10.3892/ol.2021.12571
- Article Number: 309
This article is mentioned in:
Abstract
 |
 |
|
Takata K, Matsuzaki T and Tajika Y: Aquaporins: Water channel proteins of the cell membrane. Prog Histochem Cytochem. 39:1–83. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ishibashi K, Tanaka Y and Morishita Y: The role of mammalian superaquaporins inside the cell. Biochim Biophys Acta. 1840:1507–1512. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P and Yasui M: Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. J Biol Chem. 277:39873–39879. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Sanders OI, Rensing C, Kuroda M, Mitra B and Rosen BP: Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coli. J Bacteriol. 179:3365–3367. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P and Rosen BP: Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci USA. 99:6053–6058. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Holm LM, Jahn TP, Møller AL, Schjoerring JK, Ferri D, Klaerke DA and Zeuthen T: NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes. Pflugers Arch. 450:415–428. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Herrera M, Hong NJ and Garvin JL: Aquaporin-1 transports NO across cell membranes. Hypertension. 48:157–164. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Nakhoul NL, Davis BA, Romero MF and Boron WF: Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes. Am J Physiol. 274:C543–C548. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Bienert GP, Møller AL, Kristiansen KA, Schulz A, Møller IM, Schjoerring JK and Jahn TP: Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem. 282:1183–1192. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ma T, Yang B and Verkman AS: Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun. 240:324–328. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Ma JF, Tamai K, Yamaji N, Mitani N, Konishi S, Katsuhara M, Ishiguro M, Murata Y and Yano M: A silicon transporter in rice. Nature. 440:688–691. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Yasui M, Hazama A, Kwon TH, Nielsen S, Guggino WB and Agre P: Rapid gating and anion permeability of an intracellular aquaporin. Nature. 402:184–187. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Gresz V, Kwon TH, Gong H, Agre P, Steward MC, King LS and Nielsen S: Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo. Am J Physiol Gastrointest Liver Physiol. 287:G151–G161. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Krane CM, Melvin JE, Nguyen HV, Richardson L, Towne JE, Doetschman T and Menon AG: Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem. 276:23413–23420. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC and Gabriel SE: Expression and localization of epithelial aquaporins in the adult human lung. Am J Respir Cell Mol Biol. 24:224–234. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L and Verkman AS: Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci USA. 95:2991–2996. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Burghardt B, Elkaer ML, Kwon TH, Rácz GZ, Varga G, Steward MC and Nielsen S: Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut. 52:1008–1016. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Moosavi MS and Elham Y: Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets. Pathol Oncol Res. 26:615–625. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Direito I, Madeira A, Brito MA and Soveral G: Aquaporin-5: From structure to function and dysfunction in cancer. Cell Mol Life Sci. 73:1623–1640. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Raina S, Preston GM, Guggino WB and Agre P: Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. J Biol Chem. 270:1908–1912. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Horsefield R, Nordén K, Fellert M, Backmark A, Törnroth-Horsefield S, Terwisscha van Scheltinga AC, Kvassman J, Kjellbom P, Johanson U and Neutze R: High-resolution X-ray structure of human aquaporin 5. Proc Natl Acad Sci USA. 105:13327–13332. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Woo J, Lee J, Chae YK, Kim MS, Baek JH, Park JC, Park MJ, Smith IM, Trink B, Ratovitski E, et al: Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 264:54–62. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Jung HJ, Park JY, Jeon HS and Kwon TH: Aquaporin-5: A marker protein for proliferation and migration of human breast cancer cells. PLoS One. 6:e284922011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Chen Z, Song Y, Zhang P, Hu J and Bai C: Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer. J Pathol. 221:210–220. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Shimizu H, Shiozaki A, Ichikawa D, Fujiwara H, Konishi H, Ishii H, Komatsu S, Kubota T, Okamoto K, Kishimoto M, et al: The expression and role of Aquaporin 5 in esophageal squamous cell carcinoma. J Gastroenterol. 49:655–666. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Huang YH, Zhou XY, Wang HM, Xu H, Chen J and Lv NH: Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumour Biol. 34:1743–1751. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Shi X, Wu S, Yang Y, Tang L, Wang Y, Dong J, Lü B, Jiang G and Zhao W: AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells. Tumour Biol. 35:7035–7045. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chae YK, Kang SK, Kim MS, Woo J, Lee J, Chang S, Kim DW, Kim M, Park S, Kim I, et al: Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS One. 3:e25942008. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhang Y, Wu X and Yu G: Aquaporins: New Targets for Cancer Therapy. Technol Cancer Res Treat. 15:821–828. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Z, Zhang Z, Gu Y and Bai C: Impaired migration and cell volume regulation in aquaporin 5-deficient SPC-A1 cells. Respir Physiol Neurobiol. 176:110–117. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Liu S, Zhang S, Jiang H, Yang Y and Jiang Y: Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis. Med Oncol. 30:6362013. View Article : Google Scholar : PubMed/NCBI | |
|
Kang BW, Kim JG, Lee SJ, Chae YS and Jeong JY, Yoon GS, Park SY, Kim HJ, Park JS, Choi GS and Jeong JY: Expression of aquaporin-1, aquaporin-3, and aquaporin-5 correlates with nodal metastasis in colon cancer. Oncology. 88:369–376. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Wang Z, Chong T, Chen H, Li H, Li G, Zhai X and Li Y: Over-expression of a poor prognostic marker in prostate cancer: AQP5 promotes cells growth and local invasion. World J Surg Oncol. 12:2842014. View Article : Google Scholar : PubMed/NCBI | |
|
Yang JH, Shi YF, Cheng Q and Deng L: Expression and localization of aquaporin-5 in the epithelial ovarian tumors. Gynecol Oncol. 100:294–299. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang T, Zhao C, Chen D and Zhou Z: Overexpression of AQP5 in cervical cancer: Correlation with clinicopathological features and prognosis. Med Oncol. 29:1998–2004. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Santarpia L, Lippman SM and El-Naggar AK: Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy. Expert Opin Ther Targets. 16:103–119. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Woo J, Lee J, Kim MS, Jang SJ, Sidransky D and Moon C: The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun. 367:291–298. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Zhang JN, Chen WL, Wang GS, Mao Q, Li SQ, Xiong WH, Lin YY, Ge JW, Li XX, et al: Effects of AQP5 gene silencing on proliferation, migration and apoptosis of human glioma cells through regulating EGFR/ERK/p38 MAPK signaling pathway. Oncotarget. 8:38444–38455. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kang SK, Chae YK, Woo J, Kim MS, Park JC, Lee J, Soria JC, Jang SJ, Sidransky D and Moon C: Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol. 173:518–525. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Wang W and Zheng M: Nuclear factor kappa B pathway down-regulates aquaporin 5 in the nasal mucosa of rats with allergic rhinitis. Eur Arch Otorhinolaryngol. 268:73–81. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Yan C, Zheng W and Chen X: Proliferation inhibition of cisplatin and aquaporin 5 expression in human ovarian cancer cell CAOV3. Arch Gynecol Obstet. 285:239–245. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yan C, Yang J, Shen L and Chen X: Inhibitory effect of Epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expression. Arch Gynecol Obstet. 285:459–467. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Tsai JH and Yang J: Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev. 27:2192–2206. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chen C, Ma T, Zhang C, Zhang H, Bai L, Kong L and Luo J: Down-regulation of aquaporin 5-mediated epithelial-mesenchymal transition and anti-metastatic effect by natural product Cairicoside E in colorectal cancer. Mol Carcinog. 56:2692–2705. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang W, Li Q, Yang T, Li D, Ding F, Sun H and Bai G: Anti-cancer effect of Aquaporin 5 silencing in colorectal cancer cells in association with inhibition of Wnt/β-catenin pathway. Cytotechnology. 70:615–624. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M, Nakajima A, Kogo M and Kamisaki Y: Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. Int J Oncol. 41:67–75. 2012.PubMed/NCBI | |
|
Tan SH, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, Oshima M, Tsuji T, Phuah P, Tan LT, et al: AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 578:437–443. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Guo X, Sun T, Yang M, Li Z, Li Z and Gao Y: Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma. BioMed Res Int. 2013:2065252013. View Article : Google Scholar : PubMed/NCBI | |
|
Sekine S, Shimada Y, Nagata T, Moriyama M, Omura T, Watanabe T, Hori R, Yoshioka I, Okumura T, Sawada S, et al: Prognostic significance of aquaporins in human biliary tract carcinoma. Oncol Rep. 27:1741–1747. 2012.PubMed/NCBI | |
|
Jiang XX, Xu KH, Ma JY, Tian YH, Guo XY, Lin J and Wu RJ: Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5. Oncol Lett. 4:257–261. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chae YK, Woo J, Kim MJ, Kang SK, Kim MS, Lee J, Lee SK, Gong G, Kim YH, Soria JC, et al: Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS One. 3:e21622008. View Article : Google Scholar : PubMed/NCBI | |
|
Machida Y, Ueda Y, Shimasaki M, Sato K, Sagawa M, Katsuda S and Sakuma T: Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential. Hum Pathol. 42:669–678. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Shi Z, Zhang T, Luo L, Zhao H, Cheng J, Xiang J and Zhao C: Aquaporins in human breast cancer: Identification and involvement in carcinogenesis of breast cancer. J Surg Oncol. 106:267–272. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
McCoy E and Sontheimer H: Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia. 55:1034–1043. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Lee H, Lee M, Byun SS, Lee SE and Hong SK: Evaluation of Prostate Cancer Stage Groups Updated in the 8th Edition of the American Joint Committee on Cancer Tumor-Node-Metastasis Staging Manual. Clin Genitourin Cancer. 17:e221–e226. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Pust A, Kylies D, Hube-Magg C, Kluth M, Minner S, Koop C, Grob T, Graefen M, Salomon G, Tsourlakis MC, et al: Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence. Hum Pathol. 48:102–110. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hansel NN, Sidhaye V, Rafaels NM, Gao L, Gao P, Williams R, Connett JE, Beaty TH, Mathias RA, Wise RA, et al: Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease. PLoS One. 5:e142262010. View Article : Google Scholar : PubMed/NCBI | |
|
Shen Y, Wang Y, Chen Z, Wang D, Wang X, Jin M and Bai C: Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice. J Cell Mol Med. 15:1355–1363. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Shikani AH, Sidhaye VK, Basaraba RJ, Shikani HJ, Alqudah MA, Kirk N, Cope E and Leid JG: Mucosal expression of aquaporin 5 and epithelial barrier proteins in chronic rhinosinusitis with and without nasal polyps. Am J Otolaryngol. 35:377–383. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Krane CM, Fortner CN, Hand AR, McGraw DW, Lorenz JN, Wert SE, Towne JE, Paul RJ, Whitsett JA and Menon AG: Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proc Natl Acad Sci USA. 98:14114–14119. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Aggarwal NR, Chau E, Garibaldi BT, Mock JR, Sussan T, Rao K, Rao K, Menon AG, D'Alessio FR, Damarla M, et al: Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium. Tissue Barriers. 1:e252482013. View Article : Google Scholar : PubMed/NCBI | |
|
Liu SC, Huang CM, Chang YL, Bamodu OA, Yeh CT, Wang HW, Lee FP and Lin CS: Ovatodiolide suppresses inflammatory response in BEAS-2B cells by regulating the CREB/AQP5 pathway, and sensitizes nasopharyngeal carcinoma cells to radiation therapy. Eur J Pharmacol. 859:1725482019. View Article : Google Scholar : PubMed/NCBI | |
|
Ameli PA, Madan M, Chigurupati S, Yu A, Chan SL and Pattisapu JV: Effect of acetazolamide on aquaporin-1 and fluid flow in cultured choroid plexus. Acta Neurochir Suppl (Wien). 113:59–64. 2012. View Article : Google Scholar | |
|
Tanimura Y, Hiroaki Y and Fujiyoshi Y: Acetazolamide reversibly inhibits water conduction by aquaporin-4. J Struct Biol. 166:16–21. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, Morii M, Takeguchi N, Tsukada K and Sakai H: Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci. 59:113–122. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Beck WT: The cell biology of multiple drug resistance. Biochem Pharmacol. 36:2879–2887. 1987. View Article : Google Scholar : PubMed/NCBI | |
|
Mikić D: The 2015 Nobel Prize Laureates in Physiology or Medicine. Vojnosanit Pregl. 72:951–952. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yan XJ, Xu F, Wang BS, Mao JH, Shen ZX, et al: Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci USA. 105:4826–4831. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Yu B, Luo J, Wang J, Zhang D, Yu S and Kong L: Pentasaccharide resin glycosides from Ipomoea cairica and their cytotoxic activities. Phytochemistry. 95:421–427. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, et al: Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells. Int J Oncol. 55:905–914. 2019.PubMed/NCBI | |
|
Guo XF, Yang ZR, Wang J, Lei XF, Lv XG and Dong WG: Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. Mol Med Rep. 11:2562–2568. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Verkman AS, Anderson MO and Papadopoulos MC: Aquaporins: Important but elusive drug targets. Nat Rev Drug Discov. 13:259–277. 2014. View Article : Google Scholar : PubMed/NCBI |
