Open Access

A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model

  • Authors:
    • Hui-Yen Chuang
    • Yeu-Sheng Tyan
    • Jeng-Jong Hwang
    • Kuang-Chung Shih
    • Wei-Chan Lin
  • View Affiliations

  • Published online on: February 26, 2021     https://doi.org/10.3892/ol.2021.12598
  • Article Number: 337
  • Copyright: © Chuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is difficult to diagnose at an early stage, and its prognosis is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and targets multiple receptor tyrosine kinases. However, sorafenib only extends the average survival time by 3 months. This observation indicates that sorafenib may need to be combined with other treatments to further improve outcomes. We previously showed that combination of sorafenib with radiotherapy (RT) enhances tumor inhibition in subcutaneous HCC mouse models compared with monotherapy. The present study demonstrated that combining sorafenib and RT could suppress tumor growth in an orthotopic HCC model by regulating apoptosis and NF‑κB‑related pathways. Moreover, decreased numbers of visible liver tumors and a smaller percentage of spleen metastases were found in the combination group. A transient drop in body weight was initially observed after RT, but progressive recovery of body weight occurred. The current study showed that the combination of sorafenib and RT could be a safe strategy for HCC treatment.
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April-2021
Volume 21 Issue 4

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Spandidos Publications style
Chuang H, Tyan Y, Hwang J, Shih K and Lin W: A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model. Oncol Lett 21: 337, 2021.
APA
Chuang, H., Tyan, Y., Hwang, J., Shih, K., & Lin, W. (2021). A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model. Oncology Letters, 21, 337. https://doi.org/10.3892/ol.2021.12598
MLA
Chuang, H., Tyan, Y., Hwang, J., Shih, K., Lin, W."A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model". Oncology Letters 21.4 (2021): 337.
Chicago
Chuang, H., Tyan, Y., Hwang, J., Shih, K., Lin, W."A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model". Oncology Letters 21, no. 4 (2021): 337. https://doi.org/10.3892/ol.2021.12598