Open Access

Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)

  • Authors:
    • Zhaoping Liu
    • Yanyan Wang
    • Shunling Yuan
    • Feng Wen
    • Jing Liu
    • Liheng Zou
    • Ji Zhang
  • View Affiliations

  • Published online on: March 19, 2021     https://doi.org/10.3892/ol.2021.12665
  • Article Number: 404
  • Copyright : © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Long non‑coding RNA metastasis‑associated urothelial carcinoma associated 1 (UCA1) plays a pivotal role in various human diseases. Its gene expression is regulated by several factors, including transcription factors, chromatin remodeling and epigenetic modification. UCA1 is involved in the regulation of the PI3K/AKT, Wnt/β‑catenin, MAPK, NF‑κB and JAK/STAT signaling pathways, affecting a series of cellular biological functions, such as cell proliferation, apoptosis, migration, invasion and tumor drug resistance. Furthermore, UCA1 is used as a novel potential biomarker for disease diagnosis and prognosis, as well as a target for clinical gene therapy. The present review systematically summarizes and elucidates the mechanisms of upstream transcriptional regulation of UCA1, the regulatory role of UCA1 in multiple signaling pathways in the occurrence and development of several diseases, and its potential applications in clinical treatment.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Z, Wang Y, Yuan S, Wen F, Liu J, Zou L and Zhang J: Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review). Oncol Lett 21: 404, 2021.
APA
Liu, Z., Wang, Y., Yuan, S., Wen, F., Liu, J., Zou, L., & Zhang, J. (2021). Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review). Oncology Letters, 21, 404. https://doi.org/10.3892/ol.2021.12665
MLA
Liu, Z., Wang, Y., Yuan, S., Wen, F., Liu, J., Zou, L., Zhang, J."Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)". Oncology Letters 21.5 (2021): 404.
Chicago
Liu, Z., Wang, Y., Yuan, S., Wen, F., Liu, J., Zou, L., Zhang, J."Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)". Oncology Letters 21, no. 5 (2021): 404. https://doi.org/10.3892/ol.2021.12665