Open Access

Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence

  • Authors:
    • Yen-Yun Wang
    • Pen-Tzu Fang
    • Chang-Wei Su
    • Yuk-Kwan Chen
    • Joh-Jong Huang
    • Ming-Yii Huang
    • Shyng-Shiou F. Yuan
  • View Affiliations

  • Published online on: April 7, 2021     https://doi.org/10.3892/ol.2021.12711
  • Article Number: 450
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral cancer is the fourth most common type of cancer among males in Taiwan, and the prognosis for patients with advanced‑stage oral squamous cell carcinoma (OSCC) remains poor. The present study investigated the prognostic value of three DNA repair genes, namely excision repair cross‑complementing group 1 (ERCC1), ERCC2 and X‑ray repair cross‑complementing group 1 (XRCC1) in OSCC. The protein expression levels of XRCC1, ERCC1 and ERCC2 in oral cell lines were analyzed via western blotting and immunohistochemistry using samples from 98 patients with biopsy‑proven OSCC, while the χ2 test was used to analyze the clinicopathological association. Kaplan‑Meier estimates were used to determine the prognostic value of XRCC1, ERCC1 and ERCC2 for overall survival, and the log‑rank test was used to evaluate the significance of differences. Multivariate analysis revealed a positive association between ERCC2 expression and OSCC recurrence (19.64‑fold; 95% CI, 5.00‑77.1; P<0.001). In addition, the high protein expression levels of XRCC1, ERCC1 and ERCC2 were associated with poor disease‑free and overall survival rates. Therefore, the present study suggested that high ERCC2 expression may be a risk factor for OSCC recurrence.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Y, Fang P, Su C, Chen Y, Huang J, Huang M and Yuan SF: Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence. Oncol Lett 21: 450, 2021.
APA
Wang, Y., Fang, P., Su, C., Chen, Y., Huang, J., Huang, M., & Yuan, S.F. (2021). Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence. Oncology Letters, 21, 450. https://doi.org/10.3892/ol.2021.12711
MLA
Wang, Y., Fang, P., Su, C., Chen, Y., Huang, J., Huang, M., Yuan, S. F."Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence". Oncology Letters 21.6 (2021): 450.
Chicago
Wang, Y., Fang, P., Su, C., Chen, Y., Huang, J., Huang, M., Yuan, S. F."Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence". Oncology Letters 21, no. 6 (2021): 450. https://doi.org/10.3892/ol.2021.12711